Since 2004, Justin Verlander has struck out the most hitters, with 3,451 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Justin Verlander J. Verlander	3,451	534	262	149	.637	534	3.31	26	9	0	3457.2	2,931	1,273	1,377	361	967	116	0	27	14,123	97	8.98	2.52	3.57	0.94	24.4	6.8	1.13	.279	3.58	78	3.43	81	7.63	305.9
2	Max Scherzer M. Scherzer	3,408	467	215	112	.657	458	3.16	12	5	0	2881.0	2,349	1,012	1,085	337	756	112	2	20	11,640	78	10.65	2.36	4.51	1.05	29.3	6.5	1.08	.286	3.39	76	3.18	77	7.34	307.8
3	Zack Greinke Z. Greinke	2,979	586	225	156	.591	541	3.49	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
4	Clayton Kershaw C. Kershaw	2,968	432	212	94	.693	429	2.50	25	15	0	2742.2	2,091	762	835	227	678	44	1	28	10,816	103	9.74	2.22	4.38	0.74	27.4	6.3	1.01	.270	2.74	64	2.82	70	6.86	366.8
5	CC Sabathia	2,632	465	208	136	.605	464	3.66	34	11	0	2989.1	2,867	1,216	1,336	327	850	109	0	38	12,503	57	7.92	2.56	3.10	0.98	21.1	6.8	1.24	.296	4.02	85	3.73	86	8.63	198.3
6	Cole Hamels C. Hamels	2,560	423	163	122	.572	422	3.43	17	7	0	2698.0	2,424	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
7	Felix Hernandez F. Hernandez	2,524	419	169	136	.554	418	3.42	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
8	Jon Lester J. Lester	2,488	452	200	117	.631	451	3.66	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
9	Chris Sale C. Sale	2,470	380	139	86	.618	300	3.06	16	3	12	2000.1	1,636	680	732	207	466	123	25	15	8,064	47	11.11	2.10	5.30	0.93	30.6	5.8	1.05	.298	3.29	72	2.89	69	7.36	287.9
10	Gerrit Cole G. Cole	2,251	317	153	80	.657	317	3.18	8	5	0	1954.0	1,627	690	740	217	500	61	0	8	7,861	58	10.37	2.30	4.50	1.00	28.6	6.4	1.09	.292	3.41	79	3.16	77	7.49	213.5
11	James Shields J. Shields	2,234	407	145	139	.511	405	4.01	23	9	0	2616.0	2,581	1,167	1,267	361	746	97	1	22	10,993	107	7.69	2.57	2.99	1.24	20.3	6.8	1.27	.294	4.36	98	4.16	101	8.88	-13.5
12	Adam Wainwright A. Wainwright	2,202	478	200	128	.610	411	3.53	28	11	3	2668.1	2,577	1,047	1,117	233	736	81	13	40	11,116	51	7.43	2.48	2.99	0.79	19.8	6.6	1.24	.298	3.77	88	3.53	87	8.69	152.8
13	David Price D. Price	2,076	400	157	82	.657	322	3.32	17	3	3	2143.2	1,930	790	865	221	562	63	19	16	8,807	40	8.72	2.36	3.69	0.93	23.6	6.4	1.16	.290	3.63	81	3.38	83	8.10	165.9
14	Charlie Morton C. Morton	2,075	392	138	130	.515	388	4.09	3	2	0	2157.1	2,035	981	1,079	211	809	188	0	25	9,262	69	8.66	3.38	2.56	0.88	22.4	8.7	1.32	.305	4.50	102	3.87	96	8.49	40
15	John Lackey J. Lackey	2,074	397	169	127	.571	395	3.87	15	6	0	2528.0	2,526	1,088	1,178	278	716	119	0	28	10,680	107	7.38	2.55	2.90	0.99	19.4	6.7	1.28	.300	4.19	91	3.88	94	8.99	79.3
16	A.J. Burnett	2,071	353	134	125	.517	350	4.02	15	4	0	2206.2	2,086	985	1,080	218	840	123	1	20	9,436	136	8.45	3.43	2.47	0.89	21.9	8.9	1.33	.302	4.40	98	3.81	92	8.51	86.3
17	Madison Bumgarner M. Bumgarner	2,070	358	134	124	.519	355	3.47	16	7	0	2209.1	2,007	853	933	258	544	89	1	38	9,098	29	8.43	2.22	3.81	1.05	22.8	6.0	1.15	.285	3.80	90	3.62	94	8.18	50.1
18	Lance Lynn L. Lynn	2,015	364	142	99	.589	340	3.74	4	2	1	2006.1	1,856	834	916	231	704	89	4	21	8,520	61	9.04	3.16	2.86	1.04	23.7	8.3	1.28	.296	4.11	91	3.82	93	8.33	67.8
19	Yu Darvish Y. Darvish	2,007	282	110	88	.556	282	3.58	2	1	0	1706.0	1,394	678	712	217	544	77	0	8	7,009	79	10.59	2.87	3.69	1.14	28.6	7.8	1.14	.283	3.76	85	3.53	84	7.35	125.8
20	Ervin Santana E. Santana	1,978	425	151	129	.539	386	4.11	21	11	0	2486.2	2,391	1,135	1,221	331	776	104	20	35	10,482	104	7.16	2.81	2.55	1.20	18.9	7.4	1.27	.282	4.42	99	4.31	104	8.65	-44.1
21	Dan Haren D. Haren	1,970	377	150	124	.547	366	3.71	16	6	1	2347.0	2,273	968	1,061	296	478	62	4	39	9,702	95	7.55	1.83	4.12	1.14	20.3	4.9	1.17	.287	4.07	91	3.75	92	8.72	95.5
22	Jake Peavy J. Peavy	1,961	339	134	108	.554	328	3.55	15	6	0	2084.2	1,855	822	863	215	593	69	3	35	8,581	40	8.47	2.56	3.31	0.93	22.9	6.9	1.17	.286	3.73	88	3.51	86	8.01	142.8
23	Gio Gonzalez G. Gonzalez	1,860	344	131	101	.565	328	3.70	4	2	0	1933.0	1,744	795	857	171	815	50	4	21	8,242	59	8.66	3.79	2.28	0.80	22.6	9.9	1.32	.294	3.99	91	3.67	91	8.12	77.3
24	Johnny Cueto J. Cueto	1,857	370	144	113	.560	365	3.52	18	8	0	2256.1	2,094	883	955	253	637	120	1	22	9,373	36	7.41	2.54	2.92	1.01	19.8	6.8	1.21	.283	3.81	86	3.93	96	8.35	31.8
25	Aaron Nola A. Nola	1,824	275	105	84	.556	275	3.72	6	4	0	1662.1	1,464	688	726	205	434	54	0	16	6,808	18	9.88	2.35	4.20	1.11	26.8	6.4	1.14	.293	3.93	88	3.45	81	7.93	151.5