Since 2000, Adam Dunn has the most strikeouts, with 2,379 strikeouts.

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Adam Dunn A. Dunn	2,379	2,001	6,883	1,097	1,631	334	10	462	1,168	1,317	86	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
2	Miguel Cabrera M. Cabrera	2,105	2,797	10,356	1,551	3,174	627	17	511	1,881	1,258	74	40	21	11,796	5,368	1,155	5	103	238	364	.306	.382	.518	.901	1981	585.3	.382	139	547.8
3	Justin Upton J. Upton	1,971	1,845	6,721	1,058	1,754	350	38	325	1,003	785	78	151	59	7,646	3,155	713	3	59	49	142	.261	.342	.469	.812	1082	194.2	.350	117	155.9
4	Giancarlo Stanton G. Stanton	1,963	1,649	6,025	907	1,551	305	11	429	1,103	776	53	42	15	6,893	3,165	745	0	39	88	153	.257	.345	.525	.871	1093	294.9	.368	135	288.9
5	Mark Reynolds M. Reynolds	1,927	1,688	5,432	794	1,283	253	14	298	871	707	56	64	31	6,243	2,458	565	3	45	26	117	.236	.328	.453	.780	821	94.7	.338	103	24.8
6	Nelson Cruz N. Cruz	1,916	2,055	7,501	1,090	2,053	372	15	464	1,325	738	86	84	32	8,387	3,847	851	2	60	78	179	.274	.343	.513	.856	1294	313.6	.363	129	286.2
7	Curtis Granderson C. Granderson	1,916	2,057	7,236	1,217	1,800	346	95	344	937	924	67	153	50	8,306	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
8	Paul Goldschmidt P. Goldschmidt	1,913	1,981	7,313	1,240	2,123	457	24	367	1,214	1,066	51	173	35	8,486	3,729	848	0	56	118	170	.290	.382	.510	.892	1434	441.3	.379	139	397.4
9	Chris Davis C. Davis	1,852	1,417	4,978	707	1,160	228	5	295	780	555	58	19	11	5,630	2,283	528	1	38	50	62	.233	.315	.459	.774	713	61.5	.332	106	31.8
10	Ryan Howard R. Howard	1,843	1,572	5,707	848	1,475	277	21	382	1,194	709	59	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
11	Andrew McCutchen A. McCutchen	1,808	2,175	8,030	1,254	2,193	437	50	322	1,109	1,142	94	220	89	9,342	3,696	809	3	73	70	139	.273	.367	.460	.827	1403	318.2	.358	127	295.5
12	Alfonso Soriano A. Soriano	1,800	1,966	7,742	1,150	2,094	481	31	411	1,158	496	86	289	83	8,387	3,870	923	9	54	68	123	.270	.319	.500	.819	1163	162.4	.348	111	113.3
13	Alex Rodriguez A. Rodriguez	1,792	2,142	7,994	1,528	2,324	388	20	548	1,623	1,128	152	211	44	9,364	4,396	956	0	90	93	208	.291	.385	.550	.935	1684	554.7	.397	143	508.3
14	J.D. Martinez	1,714	1,642	6,152	897	1,741	390	24	331	1,071	601	40	26	11	6,854	3,172	745	0	61	54	195	.283	.348	.516	.863	1084	280	.365	130	246.9
15	Evan Longoria E. Longoria	1,696	1,986	7,306	1,017	1,930	431	26	342	1,159	730	72	58	19	8,206	3,439	799	1	97	87	206	.264	.333	.471	.804	1119	163.4	.343	118	170.3
16	Eugenio Suárez E. Suárez	1,671	1,525	5,426	774	1,345	244	15	291	872	604	94	33	19	6,192	2,492	550	9	59	15	122	.248	.330	.459	.790	854	118.9	.339	112	90.4
17	Freddie Freeman F. Freeman	1,670	2,076	7,721	1,328	2,325	522	32	352	1,267	1,030	109	98	31	8,924	3,967	906	0	64	139	164	.301	.388	.514	.902	1538	496.3	.383	143	463.1
18	Jim Thome J. Thome	1,666	1,627	5,345	974	1,445	270	10	416	1,120	1,101	40	3	9	6,531	2,983	696	0	45	123	101	.270	.396	.558	.954	1201	402.9	.402	145	365.9
19	Torii Hunter T. Hunter	1,663	2,230	8,456	1,244	2,350	480	37	344	1,354	633	91	185	92	9,251	3,936	861	5	66	51	252	.278	.332	.465	.798	1248	151.3	.344	112	129.1
20	Carlos Beltran C. Beltran	1,660	2,416	9,047	1,458	2,515	533	68	413	1,472	1,035	46	282	41	10,245	4,423	1,014	18	99	102	184	.278	.352	.489	.841	1518	296.4	.359	120	251.8
21	David Ortiz D. Ortiz	1,647	2,297	8,293	1,361	2,379	609	19	531	1,716	1,273	33	16	9	9,689	4,619	1,159	2	88	206	225	.287	.380	.557	.937	1706	556	.394	141	483.8
22	Matt Kemp M. Kemp	1,641	1,750	6,365	950	1,808	338	37	287	1,031	518	26	184	63	6,982	3,081	662	1	72	69	184	.284	.337	.484	.821	985	172.6	.350	120	164.4
23	Joey Votto J. Votto	1,640	2,056	7,252	1,171	2,135	459	22	356	1,144	1,365	81	80	29	8,746	3,706	837	0	48	147	168	.294	.409	.511	.920	1563	539.6	.394	145	472.9
24	Adrian Beltre A. Beltre	1,590	2,704	10,335	1,422	2,976	600	33	455	1,618	773	88	100	34	11,302	5,007	1,088	8	98	100	271	.288	.340	.484	.824	1608	265.5	.352	117	222.6
25	Shin-Soo Choo S. Choo	1,579	1,652	6,087	961	1,671	339	29	218	782	868	152	157	55	7,157	2,722	586	10	40	43	101	.275	.377	.447	.824	1076	241.8	.360	123	198.1