Between the 1926 and 1935 seasons, Tony Lazzeri had the most strikeouts, with 680 strikeouts.

Interpreted as:

most strikeouts by a player from 1926 to 1935

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Tony Lazzeri T. Lazzeri	680	1,383	5,111	814	1,521	277	106	141	978	662	18	132	5,902	2,433	524	111	.298	.380	.476	.856	966	224.5	.390	125	199.5
2	Babe Ruth B. Ruth	663	1,305	4,475	1,188	1,518	224	51	405	1,270	1,122	17	49	5,680	3,059	680	66	.339	.473	.684	1.157	1460	747.2	.506	194	725.8
3	Jimmie Foxx J. Foxx	643	1,246	4,388	973	1,486	256	79	302	1,075	781	7	48	5,230	2,806	637	54	.339	.439	.639	1.079	1221	560.4	.475	169	498
4	Hack Wilson H. Wilson	633	1,176	4,187	794	1,303	240	51	228	976	609	18	43	4,906	2,329	519	92	.311	.401	.556	.957	957	338.1	.427	146	309.9
5	Lou Gehrig L. Gehrig	562	1,538	5,774	1,385	1,996	400	130	357	1,489	1,090	27	83	6,980	3,727	887	89	.346	.452	.645	1.097	1672	796.9	.484	180	767
6	Babe Herman B. Herman	504	1,379	5,169	815	1,697	370	108	167	914	475	9	88	5,744	2,784	645	91	.328	.386	.539	.924	1057	334.4	.414	140	313.9
7	Kiki Cuyler K. Cuyler	490	1,253	4,809	874	1,540	272	91	92	747	466	58	221	5,472	2,270	455	139	.320	.387	.472	.859	909	217.5	.392	125	182.3
8	Al Simmons A. Simmons	452	1,347	5,459	1,024	1,892	356	101	224	1,228	399	17	54	5,952	3,122	681	77	.347	.393	.572	.965	1171	423.7	.430	143	351.8
9	Woody English W. English	442	1,034	4,114	714	1,203	209	50	31	353	458	24	50	4,710	1,605	290	114	.292	.367	.390	.757	635	36.1	.353	101	8.4
10	Gabby Hartnett G. Hartnett	428	1,129	3,778	523	1,130	247	36	141	700	419	14	11	4,287	1,872	424	76	.299	.371	.496	.867	711	174.3	.392	128	159.7
11	Wally Berger W. Berger	427	889	3,506	549	1,078	216	48	169	633	282	19	28	3,828	1,897	433	21	.307	.362	.541	.903	672	188.6	.401	140	197.3
12	Chick Hafey C. Hafey	398	1,077	3,919	692	1,268	300	58	148	713	335	31	64	4,354	2,128	506	69	.324	.381	.543	.924	797	250.3	.413	138	222.4
13	Lefty Grove L. Grove	396	414	914	84	140	20	5	13	92	63	1	1	1,034	209	38	56	.153	.209	.229	.437	17	-113.2	.208	10	-126.1
14	Jim Bottomley J. Bottomley	393	1,325	4,997	807	1,488	302	97	158	947	469	29	42	5,620	2,458	557	125	.298	.361	.492	.853	896	191.7	.385	121	155
15	Max Bishop M. Bishop	385	1,142	3,832	848	1,038	205	29	35	331	1,015	24	31	4,955	1,406	269	84	.271	.426	.367	.793	786	162.8	.385	115	103.4
16	Travis Jackson T. Jackson	368	1,168	4,279	614	1,274	230	68	104	704	327	7	54	4,747	1,952	402	134	.298	.349	.456	.805	681	81.4	.365	110	63.6
17	Jimmy Dykes J. Dykes	361	1,223	4,250	564	1,214	258	40	50	631	563	62	38	4,987	1,702	348	112	.286	.377	.400	.778	715	89.8	.364	104	28.1
18	Mel Ott M. Ott	359	1,288	4,542	912	1,440	257	47	242	960	704	24	45	5,328	2,517	546	58	.317	.411	.554	.966	1066	393.4	.432	153	378.6
19	Bill Terry B. Terry	358	1,429	5,540	982	1,926	325	99	136	945	457	8	51	6,133	2,857	560	128	.348	.398	.516	.914	1124	350.7	.413	141	332.1
20	Red Kress R. Kress	351	1,034	3,830	529	1,100	234	48	72	628	332	6	32	4,246	1,646	354	78	.287	.345	.430	.775	574	35	.353	97	-16.4
21	Sam West S. West	350	1,096	3,972	644	1,205	226	77	51	535	384	5	45	4,437	1,738	354	76	.303	.366	.438	.803	649	90.1	.368	105	32.1
22	Goose Goslin G. Goslin	349	1,454	5,658	970	1,794	340	101	175	1,044	629	31	109	6,427	2,861	616	109	.317	.388	.506	.894	1127	319.8	.404	129	247.9
23	Chuck Klein C. Klein	347	1,057	4,236	848	1,467	287	56	232	880	385	11	58	4,677	2,562	575	45	.346	.402	.605	1.007	985	391.1	.445	150	312.5
24	Ben Chapman B. Chapman	342	874	3,400	607	1,042	195	61	59	568	389	20	183	3,858	1,536	315	49	.306	.381	.452	.833	612	126.7	.381	120	107.3
25	George Grantham G. Grantham	339	1,044	3,568	669	1,079	212	72	77	527	540	18	52	4,246	1,666	361	120	.302	.397	.467	.864	717	181.4	.396	125	146.3