10 players were tied for the most strikeouts in a game in 2023, with 5 strikeouts. The first three are Ryan McMahon on September 16, 2023, Jake Bauers on August 13, 2023 and Anthony Rizzo on July 30, 2023.

Interpreted as:

most strikeouts by a player in 2023 in one regular-season game

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Ryan McMahon R. McMahon	5	9/16/2023	COL	vs	SFG	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
2	Jake Bauers J. Bauers	5	8/13/2023	NYY	@	MIA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
3	Anthony Rizzo A. Rizzo	5	7/30/2023	NYY	@	BAL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
4	LaMonte Wade Jr. L. Wade Jr.	5	5/26/2023	SFG	@	MIL	6	0	0	0	0	0	0	0	0	0	0	6	0	0	0	0	0	0
5	Jake Burger J. Burger	5	5/23/2023	CWS	@	CLE	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Bryan De La Cruz B. De La Cruz	5	4/27/2023	MIA	@	ATL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
7	Brandon Lowe B. Lowe	5	4/24/2023	TBR	vs	HOU	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
8	Dansby Swanson D. Swanson	5	4/14/2023	CHC	@	LAD	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
9	Ramón Urías R. Urías	5	4/1/2023	BAL	@	BOS	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
10	Max Muncy M. Muncy	5	3/30/2023	LAD	vs	ARI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
11	Bobby Dalbec B. Dalbec	4	10/1/2023	BOS	@	BAL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
12	Tyler Naquin T. Naquin	4	10/1/2023	CWS	vs	SDP	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
13	Maikel Garcia M. Garcia	4	9/30/2023	KCR	vs	NYY	5	1	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0
14	Ryan McMahon R. McMahon	4	9/29/2023	COL	vs	MIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
15	Garrett Hampson G. Hampson	4	9/27/2023	MIA	@	NYM	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
16	Elias Díaz E. Díaz	4	9/27/2023	COL	vs	LAD	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
17	J.D. Martinez	4	9/27/2023	LAD	@	COL	5	0	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0
18	Julio Rodríguez J. Rodríguez	4	9/27/2023	SEA	vs	HOU	4	0	0	0	0	0	0	1	0	1	0	5	0	0	0	0	0	0
19	Ke'Bryan Hayes K. Hayes	4	9/26/2023	PIT	@	PHI	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
20	Lawrence Butler L. Butler	4	9/26/2023	OAK	@	MIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
21	Bobby Dalbec B. Dalbec	4	9/23/2023	BOS	vs	CWS	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
22	Jazz Chisholm Jr. J. Chisholm Jr.	4	9/23/2023	MIA	vs	MIL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
23	Liover Peguero L. Peguero	4	9/22/2023	PIT	@	CIN	4	0	0	0	0	0	0	1	0	0	0	5	0	0	0	0	0	0
24	Logan O'Hoppe L. O'Hoppe	4	9/21/2023	LAA	@	TBR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
25	Marcell Ozuna M. Ozuna	4	9/21/2023	ATL	@	WSH	5	0	0	0	0	0	1	1	0	0	0	6	0	0	0	0	0	0