Tom Cheney has struck out the most batters in a game, with 21 strikeouts versus the Orioles on September 12, 1962.

most strikeouts in a game by one pitcher yabkee
Interpreted as:
most strikeouts in a regular-season game by one pitcher yabkee
9/12/1962 Cheney 5/11/2016 Scherzer 5/8/2001 Johnson 5/6/1998 Wood 9/18/1996 Clemens 4/29/1986 Clemens 8/8/1997 Johnson 6/24/1997 Johnson 10/6/1991 Cone 6/8/1977 Ryan 8/20/1974 Ryan 8/12/1974 Ryan 6/14/1974 Ryan 4/22/1970 Seaver 9/15/1969 Carlton 7/3/1968 Tiant 5/13/2015 Kluber 5/16/2004 Sheets 8/25/1998 Clemens 9/27/1992 Johnson 6/4/1990 Martinez 9/10/1980 Gullickson 6/17/1978 Guidry 9/10/1976 Ryan 7/14/1968 Wilson 10/2/1965 Short 6/14/1965 Maloney 0 2 4 6 8 10 12 14 16 18 20 21 20 20 20 20 20 19 19 19 19 19 19 19 19 19 19 18 18 18 18 18 18 18 18 18 18 18
NAME SO DATE TM OPP DEC GS ERA CG SHO SV IP H ER R HR BB HBP GF IBB TBF WP
Tom Cheney Tom Cheney 21 9/12/1962
WSH WSH
@
BAL BAL
W 1 0.56 1 0 0 16.0 10 1 1 0 4 0 0 0 62 1
Max Scherzer Max Scherzer 20 5/11/2016
WSH WSH
vs
DET DET
W 1 2.00 1 0 0 9.0 6 2 2 2 0 0 0 0 33 0
Randy Johnson Randy Johnson 20 5/8/2001
ARI ARI
vs
CIN CIN
1 1.00 0 0 0 9.0 3 1 1 0 0 0 0 0 29 0
Kerry Wood Kerry Wood 20 5/6/1998
CHC CHC
vs
HOU HOU
W 1 0.00 1 1 0 9.0 1 0 0 0 0 1 0 0 29 0
Roger Clemens Roger Clemens 20 9/18/1996
BOS BOS
@
DET DET
W 1 0.00 1 1 0 9.0 5 0 0 0 0 0 0 0 32 1
Roger Clemens Roger Clemens 20 4/29/1986
BOS BOS
vs
SEA SEA
W 1 1.00 1 0 0 9.0 3 1 1 1 0 0 0 0 30 0
Randy Johnson Randy Johnson 19 8/8/1997
SEA SEA
vs
CWS CWS
W 1 0.00 1 1 0 9.0 5 0 0 0 3 0 0 0 35 0
Randy Johnson Randy Johnson 19 6/24/1997
SEA SEA
vs
OAK OAK
L 1 4.00 1 0 0 9.0 11 4 4 2 0 0 0 0 37 0
David Cone David Cone 19 10/6/1991
NYM NYM
@
PHI PHI
W 1 0.00 1 1 0 9.0 3 0 0 0 1 0 0 0 31 0
Nolan Ryan Nolan Ryan 19 6/8/1977
CAL CAL
vs
TOR TOR
1 0.00 0 0 0 10.0 6 0 1 0 5 0 0 1 41 2
Nolan Ryan Nolan Ryan 19 8/20/1974
CAL CAL
vs
DET DET
L 1 0.82 1 0 0 11.0 4 1 1 0 5 0 0 0 41 0
Nolan Ryan Nolan Ryan 19 8/12/1974
CAL CAL
vs
BOS BOS
W 1 2.00 1 0 0 9.0 7 2 2 0 2 0 0 0 36 1
Nolan Ryan Nolan Ryan 19 6/14/1974
CAL CAL
vs
BOS BOS
1 2.08 0 0 0 13.0 8 3 3 1 10 0 0 0 58 0
Tom Seaver Tom Seaver 19 4/22/1970
NYM NYM
vs
SDP SDP
W 1 1.00 1 0 0 9.0 2 1 1 1 2 0 0 0 31 0
Steve Carlton Steve Carlton 19 9/15/1969
STL STL
vs
NYM NYM
L 1 4.00 1 0 0 9.0 9 4 4 2 2 0 0 0 38 1
Luis Tiant Luis Tiant 19 7/3/1968
CLE CLE
vs
MIN MIN
W 1 0.00 1 1 0 10.0 6 0 0 0 0 0 0 0 36 0
Corey Kluber Corey Kluber 18 5/13/2015
CLE CLE
vs
STL STL
W 1 0.00 0 0 0 8.0 1 0 0 0 0 1 0 0 26 0
Ben Sheets Ben Sheets 18 5/16/2004
MIL MIL
vs
ATL ATL
W 1 1.00 1 0 0 9.0 3 1 1 1 1 0 0 0 31 0
Roger Clemens Roger Clemens 18 8/25/1998
TOR TOR
vs
KCR KCR
W 1 0.00 1 1 0 9.0 3 0 0 0 0 0 0 0 30 0
Randy Johnson Randy Johnson 18 9/27/1992
SEA SEA
@
TEX TEX
1 2.25 0 0 0 8.0 6 2 2 0 4 0 0 0 34 0
Ramon Martinez Ramon Martinez 18 6/4/1990
LAD LAD
vs
ATL ATL
W 1 0.00 1 1 0 9.0 3 0 0 0 1 0 0 0 31 0
Bill Gullickson Bill Gullickson 18 9/10/1980
MON MON
vs
CHC CHC
W 1 2.00 1 0 0 9.0 4 2 2 0 2 0 0 0 33 1
Ron Guidry Ron Guidry 18 6/17/1978
NYY NYY
vs
CAL CAL
W 1 0.00 1 1 0 9.0 4 0 0 0 2 0 0 0 33 0
Nolan Ryan Nolan Ryan 18 9/10/1976
CAL CAL
@
CWS CWS
W 1 2.00 1 0 0 9.0 3 2 2 0 9 0 0 0 41 0
Don Wilson Don Wilson 18 7/14/1968
HOU HOU
@
CIN CIN
W 1 1.00 1 0 0 9.0 5 1 1 0 2 0 0 0 33 1
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Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.

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