The New York Yankees had their most strikeouts in a game against the Cubs on May 7, 2017, with 22 strikeouts.

Interpreted as:

most strikeouts in a regular-season game by yankee

	TEAM	SO	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	22	5/7/2017	NYY	@	CHC	W 5-4	63	5	10	0	1	1	5	5	0	3	0	70	15	2	2	0	0	0	.159	.221	.238	.459
2	Yankees	19	7/15/2017	NYY	@	BOS	W 4-1	55	4	9	3	0	1	4	9	0	1	1	66	15	4	1	1	1	1	.164	.277	.273	.550
3	Yankees	18	7/30/2023	NYY	@	BAL	L 3-9	36	3	9	3	0	1	3	3	0	0	0	40	15	4	0	1	0	0	.250	.300	.417	.717
4	Yankees	18	4/3/2019	NYY	vs	DET	L 1-2	31	1	5	1	0	0	1	4	0	1	1	35	6	1	0	0	0	0	.161	.257	.194	.451
5	Yankees	17	8/8/2023	NYY	@	CWS	W 7-1	37	7	13	1	0	2	7	6	0	1	2	44	20	3	0	1	0	0	.351	.432	.541	.972
6	Yankees	17	7/17/2023	NYY	@	LAA	L 3-4	35	3	8	1	0	0	3	6	0	1	0	42	9	1	0	1	0	1	.229	.333	.257	.590
7	Yankees	17	5/8/2021	NYY	vs	WSH	W 4-3	36	4	6	0	0	1	4	4	0	0	0	40	9	1	0	0	0	0	.167	.250	.250	.500
8	Yankees	17	5/12/2019	NYY	@	TBR	W 7-1	34	7	9	3	0	1	6	5	0	0	0	41	15	4	1	1	1	0	.265	.350	.441	.791
9	Yankees	17	5/29/2018	NYY	vs	HOU	W 6-5	43	6	14	4	0	3	6	2	0	0	0	45	27	7	0	0	0	0	.326	.356	.628	.983
10	Yankees	17	5/21/2017	NYY	@	TBR	W 3-2	35	3	7	1	0	1	3	3	0	0	0	38	11	2	0	0	0	1	.200	.263	.314	.577
11	Yankees	17	4/15/2017	NYY	vs	STL	W 3-2	31	3	5	1	0	0	2	8	0	2	0	39	6	1	0	0	0	0	.161	.333	.194	.527
12	Yankees	17	8/11/2010	NYY	@	TEX	W 7-6	38	7	12	3	1	1	6	3	0	1	0	41	20	5	0	0	0	1	.316	.366	.526	.892
13	Yankees	17	9/30/2001	NYY	vs	BAL	N 1-1	48	1	5	0	0	1	1	5	1	1	1	56	8	1	2	0	1	0	.104	.204	.167	.370
14	Yankees	17	9/10/1999	NYY	vs	BOS	L 1-3	27	1	1	0	0	1	1	0	1	0	1	28	4	1	0	0	0	0	.037	.071	.148	.220
15	Yankees	16	4/2/2025	NYY	vs	AZ	L 3-4	34	3	6	1	0	1	3	0	0	0	0	34	10	2	0	0	0	0	.176	.176	.294	.471
16	Yankees	16	8/28/2023	NYY	@	DET	W 4-1	35	4	7	1	0	2	4	6	0	0	0	41	14	3	0	0	0	0	.200	.317	.400	.717
17	Yankees	16	7/19/2023	NYY	@	LAA	L 3-7	35	3	8	1	0	2	3	3	1	0	0	39	15	3	0	0	0	0	.229	.308	.429	.736
18	Yankees	16	3/30/2023	NYY	vs	SFG	W 5-0	32	5	8	0	0	2	5	2	0	2	0	34	14	2	0	0	0	0	.250	.294	.438	.732
19	Yankees	16	7/13/2022	NYY	vs	CIN	W 7-6	35	7	6	2	0	1	6	4	0	1	0	39	11	3	0	0	1	0	.171	.256	.314	.571
20	Yankees	16	8/15/2021	NYY	@	CWS	W 5-3	38	5	9	2	0	2	4	8	0	1	0	46	17	4	0	0	1	0	.237	.370	.447	.817
21	Yankees	16	9/25/2019	NYY	@	TBR	L 0-4	27	0	1	0	0	0	0	5	0	0	0	32	1	0	0	0	0	1	.037	.188	.037	.225
22	Yankees	16	9/15/2018	NYY	vs	TOR	L 7-8	35	7	8	1	0	4	7	8	1	0	0	44	21	5	0	0	0	0	.229	.386	.600	.986
23	Yankees	16	5/14/2017	NYY	vs	HOU	L 7-10	36	7	10	2	0	1	5	6	1	0	0	43	15	3	0	0	0	1	.278	.395	.417	.812
24	Yankees	16	8/11/2015	NYY	@	CLE	L 4-5	54	4	8	1	0	2	4	3	0	0	1	57	15	3	0	0	0	0	.148	.193	.278	.471
25	Yankees	16	4/29/2015	NYY	vs	TBR	L 2-3	43	2	7	0	0	2	2	3	1	1	1	48	13	2	1	0	0	1	.163	.234	.302	.536