Reggie Jackson has the most career strikeouts at home, with 1,305 strikeouts.

Interpreted as:

most strikeouts by a player in a home debut

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reggie Jackson R. Jackson	1,305	1,410	4,799	730	1,226	196	23	280	826	663	46	99	50	5,546	2,308	499	7	31	82	82	.255	.349	.481	.830
2	Jim Thome J. Thome	1,230	1,287	4,189	836	1,157	222	15	339	921	900	40	13	8	5,165	2,426	576	1	35	91	80	.276	.406	.579	.985
3	Adam Dunn A. Dunn	1,206	1,009	3,431	562	809	153	2	245	608	665	50	30	13	4,169	1,701	400	0	23	71	47	.236	.366	.496	.861
4	Alex Rodriguez A. Rodriguez	1,131	1,396	5,223	1,022	1,574	283	14	354	1,076	652	91	180	30	6,032	2,947	651	7	59	49	141	.301	.385	.564	.949
5	Sammy Sosa S. Sosa	1,098	1,184	4,333	738	1,199	188	27	321	853	490	24	109	54	4,897	2,404	536	7	43	83	102	.277	.350	.555	.905
6	Giancarlo Stanton G. Stanton	987	877	3,081	501	814	147	5	235	635	426	26	24	10	3,557	1,676	387	0	24	47	83	.264	.356	.544	.900
7	Miguel Cabrera M. Cabrera	986	1,405	5,058	801	1,609	329	10	256	964	638	40	19	11	5,796	2,726	595	3	57	121	174	.318	.395	.539	.934
8	Paul Goldschmidt P. Goldschmidt	983	1,042	3,704	668	1,047	229	15	184	609	579	25	89	20	4,332	1,858	428	0	24	68	80	.283	.381	.502	.883
9	Nelson Cruz N. Cruz	958	1,046	3,762	557	1,045	195	8	230	679	385	43	46	17	4,226	1,946	433	0	36	37	78	.278	.349	.517	.866
10	Mike Cameron M. Cameron	938	975	3,330	507	804	180	31	123	436	435	36	155	42	3,846	1,415	334	17	28	9	54	.241	.333	.425	.758
11	Andres Galarraga A. Galarraga	937	1,114	3,931	646	1,207	252	20	202	771	309	92	62	52	4,366	2,105	474	1	33	57	88	.307	.368	.535	.904
12	Justin Upton J. Upton	930	915	3,237	572	918	177	21	190	560	401	44	67	29	3,716	1,707	388	1	33	29	72	.284	.367	.527	.894
13	Mark Reynolds M. Reynolds	917	839	2,620	406	627	126	10	149	442	363	31	29	19	3,038	1,220	285	0	24	11	64	.239	.336	.466	.802
14	Tony Perez T. Perez	915	1,413	4,843	643	1,373	274	53	182	853	475	22	25	15	5,401	2,299	509	7	54	71	132	.284	.347	.475	.821
15	Eugenio Suárez E. Suárez	912	816	2,817	413	700	119	9	177	495	334	52	14	8	3,239	1,368	305	5	31	11	63	.248	.336	.486	.821
16	Willie Stargell W. Stargell	910	1,178	3,848	586	1,115	219	46	221	781	487	34	7	7	4,418	2,089	486	7	42	123	74	.290	.371	.543	.914
17	Jose Canseco J. Canseco	902	920	3,347	571	891	148	7	219	670	457	40	107	50	3,882	1,710	374	0	38	34	80	.266	.358	.511	.868
18	Manny Ramirez M. Ramirez	897	1,151	4,016	778	1,247	258	11	282	947	670	59	16	19	4,790	2,373	551	1	44	127	124	.311	.413	.591	1.003
19	Mike Schmidt M. Schmidt	897	1,202	4,020	784	1,094	220	31	265	825	788	48	82	45	4,922	2,171	516	6	60	104	84	.272	.393	.540	.933
20	Derek Jeter D. Jeter	891	1,391	5,517	1,013	1,727	273	30	138	666	569	82	194	44	6,241	2,474	441	51	22	21	136	.313	.384	.448	.833
21	Andrew McCutchen A. McCutchen	890	1,137	4,075	648	1,138	240	25	149	566	615	50	113	46	4,781	1,875	414	3	38	49	84	.279	.377	.460	.837
22	Curtis Granderson C. Granderson	884	1,021	3,518	572	842	165	43	158	464	437	31	63	26	4,030	1,567	366	17	27	15	30	.239	.326	.445	.772
23	Ryan Howard R. Howard	883	769	2,756	441	723	129	11	197	578	366	28	8	3	3,171	1,465	337	0	21	76	54	.262	.352	.532	.884
24	Chris Davis C. Davis	882	719	2,467	374	588	103	1	160	409	276	31	13	5	2,795	1,173	264	1	20	29	33	.238	.320	.475	.796
25	Craig Biggio C. Biggio	882	1,447	5,481	948	1,579	365	34	143	599	592	148	233	65	6,313	2,441	542	52	40	32	68	.288	.370	.445	.816

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StatMuse has game-level data for strikeouts going back to the 1916 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Fri 3/27	ATH	@	TOR	7:07 PM
Sat 3/28	ATH	@	TOR	3:07 PM
Sun 3/29	ATH	@	TOR	1:37 PM
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Braves	76	86	.469	20.0
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Tue 9/16	ATL	@	WSH	9-4
Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Reggie Jackson has the most career strikeouts at home, with 1,305 strikeouts.

Interpreted as:

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