6 players are tied for the most strikeouts in a game this season, with 5 strikeouts. The first three are Austin Slater on June 12, Tyler Stephenson on May 6 and Nick Castellanos on April 10.

Interpreted as:

most strikeouts by a player in regular-season game in MLB this season

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Austin Slater A. Slater	5	6/12/2025	CWS	@	HOU	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
2	Tyler Stephenson T. Stephenson	5	5/6/2025	CIN	@	ATL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
3	Nick Castellanos N. Castellanos	5	4/10/2025	PHI	@	ATL	5	1	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
4	Jose Altuve J. Altuve	5	4/3/2025	HOU	@	MIN	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
5	Dylan Crews D. Crews	5	3/29/2025	WSH	vs	PHI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Jackson Chourio J. Chourio	5	3/27/2025	MIL	@	NYY	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
7	Joey Bart J. Bart	4	6/23/2025	PIT	@	MIL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
8	Willson Contreras W. Contreras	4	6/21/2025	STL	vs	CIN	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
9	Ryan Noda R. Noda	4	6/20/2025	CWS	@	TOR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
10	Jose Altuve J. Altuve	4	6/20/2025	HOU	@	LAA	4	0	0	0	0	0	0	1	0	0	0	5	0	0	0	0	1	0
11	Ryan McMahon R. McMahon	4	6/20/2025	COL	vs	AZ	5	1	1	0	0	1	1	0	0	0	0	5	4	1	0	0	0	0
12	Oneil Cruz O. Cruz	4	6/19/2025	PIT	@	DET	6	0	0	0	0	0	0	0	0	0	0	6	0	0	0	0	0	0
13	Shohei Ohtani S. Ohtani	4	6/17/2025	LAD	vs	SDP	4	0	0	0	0	0	0	0	1	0	0	5	0	0	0	0	0	0
14	Hunter Goodman H. Goodman	4	6/15/2025	COL	@	ATL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
15	Harrison Bader H. Bader	4	6/15/2025	MIN	@	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
16	Ryan McMahon R. McMahon	4	6/14/2025	COL	@	ATL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
17	Bo Naylor B. Naylor	4	6/14/2025	CLE	@	SEA	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
18	Lars Nootbaar L. Nootbaar	4	6/13/2025	STL	@	MIL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
19	José Tena J. Tena	4	6/13/2025	WSH	vs	MIA	5	0	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0
20	LaMonte Wade Jr. L. Wade Jr.	4	6/13/2025	LAA	@	BAL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
21	Lars Nootbaar L. Nootbaar	4	6/11/2025	STL	vs	TOR	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
22	Rhys Hoskins R. Hoskins	4	6/9/2025	MIL	vs	ATL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
23	Riley Greene R. Greene	4	6/7/2025	DET	vs	CHC	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
24	Salvador Perez S. Perez	4	6/7/2025	KCR	@	CWS	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
25	Will Wilson W. Wilson	4	6/7/2025	CLE	vs	HOU	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0