8 players are tied for the most strikeouts in a game, with 6 strikeouts. The first three are Geoff Jenkins on June 8, 2004, Alex Gonzalez on September 9, 1998 and Sam Horn on July 17, 1991.

Interpreted as:

most strikeouts by a player in single regular-season game ever

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Geoff Jenkins G. Jenkins	6	6/8/2004	MIL	@	ANA	7	0	0	0	0	0	0	0	0	0	0	7	0	0	0	0	0	0
2	Alex Gonzalez A. Gonzalez	6	9/9/1998	TOR	vs	CLE	6	0	0	0	0	0	0	0	0	0	0	6	0	0	0	0	0	0
3	Sam Horn S. Horn	6	7/17/1991	BAL	@	KCR	7	2	1	1	0	0	0	1	0	0	0	8	2	1	0	0	0	0
4	Cecil Cooper C. Cooper	6	6/14/1974	BOS	@	CAL	8	0	0	0	0	0	0	0	0	0	0	8	0	0	0	0	0	0
5	Billy Cowan B. Cowan	6	7/9/1971	CAL	@	OAK	8	0	0	0	0	0	0	0	0	0	0	8	0	0	0	0	0	0
6	Rick Reichardt R. Reichardt	6	5/31/1966	CAL	vs	CLE	8	0	0	0	0	0	0	0	0	0	0	8	0	0	0	0	0	0
7	Don Hoak D. Hoak	6	5/2/1956	CHC	vs	NYG	7	0	1	0	0	0	0	1	0	0	0	9	1	0	1	0	0	0
8	Carl Weilman C. Weilman	6	7/25/1913	SLA	@	WSH	6	0	0	0	0	0		0	0	0		6	0	0	0
9	Tyler Stephenson T. Stephenson	5	5/6/2025	CIN	@	ATL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
10	Nick Castellanos N. Castellanos	5	4/10/2025	PHI	@	ATL	5	1	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
11	Jose Altuve J. Altuve	5	4/3/2025	HOU	@	MIN	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
12	Dylan Crews D. Crews	5	3/29/2025	WSH	vs	PHI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
13	Jackson Chourio J. Chourio	5	3/27/2025	MIL	@	NYY	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
14	Aaron Judge A. Judge	5	9/28/2024	NYY	vs	PIT	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
15	Connor Norby C. Norby	5	9/26/2024	MIA	@	MIN	6	0	0	0	0	0	0	1	0	0	0	7	0	0	0	0	0	0
16	Mark Vientos M. Vientos	5	9/21/2024	NYM	vs	PHI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
17	Randy Arozarena R. Arozarena	5	8/17/2024	SEA	@	PIT	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
18	Julio Rodríguez J. Rodríguez	5	8/11/2024	SEA	vs	NYM	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
19	Jake Burger J. Burger	5	7/4/2024	MIA	vs	BOS	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
20	Nolan Jones N. Jones	5	6/30/2024	COL	@	CWS	6	0	0	0	0	0	0	0	0	0	0	6	0	0	0	0	0	0
21	Ryan McMahon R. McMahon	5	9/16/2023	COL	vs	SFG	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
22	Jake Bauers J. Bauers	5	8/13/2023	NYY	@	MIA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
23	Anthony Rizzo A. Rizzo	5	7/30/2023	NYY	@	BAL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
24	LaMonte Wade Jr. L. Wade Jr.	5	5/26/2023	SFG	@	MIL	6	0	0	0	0	0	0	0	0	0	0	6	0	0	0	0	0	0
25	Jake Burger J. Burger	5	5/23/2023	CWS	@	CLE	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0