Between the 1880 and 1889 seasons, Tim Keefe struck out the most hitters, with 2,219 strikeouts.

Interpreted as:

most strikeouts by a player thrown in 1880s pitcher

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Tim Keefe T. Keefe	2,219	490	291	180	.618	487	2.47	470	36	1	4196.0	3,580	1,153	1,948	59	909	41	4	17,162	208	4.76	1.95	2.44	0.13	12.9	5.3	1.07	.253	4.18	77	2.81	87	7.68	196.4
2	Mickey Welch M. Welch	1,706	505	285	187	.604	496	2.62	478	39	3	4344.2	4,132	1,266	2,266	94	1,074	29	10	18,244	259	3.53	2.22	1.59	0.19	9.4	5.9	1.20	.263	4.69	87	3.19	102	8.56	-30.1
3	Old Hoss Radbourn O. Hoss Radbourn	1,696	460	271	169	.616	440	2.54	429	32	3	3966.1	3,740	1,118	1,941	97	713	30	19	16,458	198	3.85	1.62	2.38	0.22	10.3	4.3	1.12	.262	4.40	80	3.07	95	8.49	41.8
4	Jim Whitney J. Whitney	1,565	407	189	202	.483	392	2.95	374	26	2	3456.1	3,537	1,131	1,999	78	400	27	14	14,475	214	4.08	1.04	3.91	0.20	10.8	2.8	1.14	.279	5.21	96	2.73	87	9.21	149.1
5	Pud Galvin P. Galvin	1,526	548	287	242	.543	536	2.87	508	48	1	4696.2	5,030	1,500	2,583	102	548	29	15	19,841	182	2.92	1.05	2.78	0.20	7.7	2.8	1.19	.280	4.95	94	2.97	94	9.64	77.9
6	Jim McCormick J. McCormick	1,471	416	240	166	.591	411	2.46	395	29	1	3612.1	3,382	986	1,740	79	660	12	6	14,887	126	3.66	1.64	2.23	0.20	9.9	4.4	1.12	.261	4.34	84	2.95	99	8.43	-13.5
7	John Clarkson J. Clarkson	1,470	329	220	98	.692	326	2.54	309	26	1	2858.0	2,609	808	1,408	102	624	35	3	11,859	115	4.63	1.97	2.36	0.32	12.4	5.3	1.13	.260	4.43	71	3.11	84	8.22	227.7
8	Charlie Buffinton C. Buffinton	1,423	317	181	120	.601	307	2.86	281	28	1	2660.0	2,599	844	1,372	67	564	14	10	11,184	135	4.81	1.91	2.52	0.23	12.7	5.0	1.19	.278	4.64	88	2.96	87	8.79	128.5
9	Tony Mullane T. Mullane	1,338	368	203	138	.595	344	2.78	329	26	7	3078.1	2,800	952	1,628	48	709	74	25	12,938	256	3.91	2.07	1.89	0.14	10.3	5.5	1.14	.257	4.76	82	3.20	95	8.19	62.3
10	Toad Ramsey T. Ramsey	1,258	204	90	107	.457	201	3.22	191	4	0	1752.0	1,616	626	1,152	30	569	30	3	7,550	151	6.46	2.92	2.21	0.15	16.7	7.5	1.25	.281	5.92	87	2.87	79	8.30	147.9
11	Ed Morris E. Morris	1,192	293	163	115	.586	292	2.70	282	28	1	2533.2	2,290	760	1,196	37	463	22	1	10,422	109	4.23	1.64	2.57	0.13	11.4	4.4	1.09	.260	4.25	85	2.86	91	8.13	33
12	Larry Corcoran L. Corcoran	1,103	277	177	89	.665	268	2.36	256	22	2	2392.1	2,147	626	1,235	68	496	2	9	10,001	113	4.15	1.87	2.22	0.26	11.0	5.0	1.10	.250	4.65	79	2.99	97	8.08	41
13	Matt Kilroy M. Kilroy	1,082	236	121	99	.550	233	3.26	222	18	0	1974.0	1,884	715	1,183	32	560	70	4	8,438	184	4.93	2.55	1.93	0.15	12.8	6.6	1.24	.277	5.39	92	3.15	88	8.59	86.4
14	Guy Hecker G. Hecker	1,078	322	173	137	.558	310	2.83	301	15	1	2804.1	2,762	883	1,615	41	448	25	11	11,853	124	3.46	1.44	2.41	0.13	9.1	3.8	1.14	.266	5.18	83	3.06	92	8.86	68.7
15	Bobby Mathews B. Mathews	1,063	225	130	84	.607	219	3.03	206	7	2	1900.0	1,913	640	1,146	38	269	3	6	8,152	100	5.04	1.27	3.95	0.18	13.0	3.3	1.15	.278	5.43	92	2.69	84	9.06	115.4
16	Adonis Terry A. Terry	950	219	94	107	.468	209	3.43	199	12	4	1812.1	1,723	691	1,130	38	521	34	10	7,747	127	4.72	2.59	1.82	0.19	12.3	6.7	1.24	.273	5.61	98	3.27	95	8.56	31.1
17	Dupee Shaw D. Shaw	950	211	83	121	.407	207	3.10	196	13	0	1762.0	1,710	607	1,050	41	396	3	4	7,555	85	4.85	2.02	2.40	0.21	12.6	5.2	1.20	.271	5.36	99	3.04	96	8.73	2.4
18	Hardie Henderson H. Henderson	930	210	81	121	.401	206	3.50	197	4	0	1788.1	1,800	696	1,230	25	522	7	4	7,852	178	4.68	2.63	1.78	0.13	11.8	6.6	1.30	.281	6.19	106	3.21	98	9.06	5
19	Stump Wiedman S. Wiedman	910	279	101	156	.393	269	3.61	249	13	2	2318.1	2,594	929	1,536	62	459	12	10	10,144	102	3.53	1.78	1.98	0.24	9.0	4.5	1.32	.291	5.96	114	3.19	99	10.07	7.4
20	Pretzels Getzien P. Getzien	865	231	113	108	.511	229	3.35	218	7	1	1983.2	2,045	738	1,196	80	462	19	2	8,509	96	3.92	2.10	1.87	0.36	10.2	5.4	1.26	.277	5.43	99	3.37	95	9.28	34.6
21	Jack Lynch J. Lynch	858	220	110	104	.514	215	3.65	213	8	0	1915.1	2,026	777	1,206	53	290	4	5	8,161	137	4.03	1.36	2.96	0.25	10.5	3.6	1.21	.285	5.67	111	3.07	96	9.52	15.8
22	Hugh Daily H. Daily	846	165	73	87	.456	163	2.92	157	10	1	1415.0	1,394	459	866	31	369	3	2	6,060	96	5.38	2.35	2.29	0.20	14.0	6.1	1.25	.283	5.51	94	3.02	101	8.87	-14.7
23	Bob Caruthers B. Caruthers	746	249	175	64	.732	235	2.62	229	21	1	2130.0	1,932	619	970	33	376	39	14	8,761	106	3.15	1.59	1.98	0.14	8.5	4.3	1.08	.252	4.10	73	3.10	89	8.16	89.8
24	Charlie Ferguson C. Ferguson	728	183	99	64	.607	170	2.67	165	13	4	1514.2	1,402	450	793	42	290	11	12	6,310	64	4.33	1.72	2.51	0.25	11.5	4.6	1.12	.260	4.71	85	3.12	92	8.33	42.5
25	Dave Foutz D. Foutz	713	206	129	55	.701	189	2.72	178	16	1	1693.1	1,521	511	895	32	416	15	15	7,093	87	3.79	2.21	1.71	0.17	10.1	5.9	1.14	.253	4.76	75	3.28	94	8.08	47.9