Since 1969, the San Diego Padres have lost the most games by a team, with 4,789 losses.

Interpreted as:

most team regular-season losses since 1969 in MLB

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	4,789	4,214	.532	9,005	.468	304,394	36,524	75,910	13,444	1,772	7,365	34,352	28,968	2,170	60,282	6,073	2,624	341,558	114,993	22,581	3,748	2,278	2,699	6,573	.249	.317	.378	.695
2	Royals	4,702	4,287	.523	8,991	.477	307,454	39,299	80,685	15,114	2,302	7,126	37,106	26,297	2,511	52,853	7,157	2,921	341,343	121,781	24,542	2,388	2,693	1,878	6,853	.262	.323	.396	.719
3	Nationals	4,663	4,330	.519	8,997	.481	304,265	37,692	77,163	14,893	1,810	7,707	35,435	28,552	2,661	58,115	6,630	2,809	341,681	118,797	24,410	3,888	2,315	2,891	6,574	.254	.321	.390	.711
4	Tigers	4,646	4,346	.517	8,993	.483	307,216	40,542	79,535	14,176	2,031	9,279	38,452	29,170	2,369	58,819	4,457	2,377	343,452	125,610	25,486	2,168	2,529	1,860	6,883	.259	.325	.409	.734
5	Pirates	4,638	4,346	.516	8,990	.484	306,400	38,279	78,703	14,832	2,141	7,445	36,155	27,405	2,751	59,083	5,854	2,681	342,582	120,152	24,418	3,509	2,517	2,832	6,454	.257	.321	.392	.713
6	White Sox	4,621	4,363	.514	8,993	.486	306,002	40,135	79,448	14,065	1,694	8,863	38,043	27,964	2,668	55,773	5,445	2,622	341,884	123,490	24,622	2,682	2,568	1,881	6,988	.260	.325	.404	.728
7	Rangers	4,612	4,377	.513	8,994	.487	307,837	41,682	80,423	14,639	1,622	9,304	39,424	29,268	2,519	58,098	5,576	2,597	344,646	126,218	25,565	2,448	2,574	1,991	6,887	.261	.328	.410	.738
8	Brewers	4,593	4,404	.511	9,001	.489	305,590	40,102	78,299	14,596	1,769	8,829	37,988	29,430	2,759	59,765	6,083	2,770	343,410	122,920	25,194	3,177	2,454	2,167	6,680	.256	.325	.402	.727
9	Twins	4,580	4,412	.509	8,995	.491	308,721	40,908	81,566	15,241	1,950	8,042	38,569	28,651	2,681	55,453	4,951	2,483	344,907	124,833	25,233	2,266	2,588	2,075	7,382	.264	.329	.404	.734
10	Cubs	4,577	4,409	.509	8,995	.491	306,621	39,537	78,521	14,421	1,851	8,789	37,315	29,037	2,490	59,779	5,021	2,441	344,045	123,011	25,061	3,533	2,364	2,737	6,580	.256	.323	.401	.724
11	Angels	4,523	4,478	.502	9,003	.498	306,144	39,747	78,879	13,868	1,540	8,435	37,475	28,604	2,620	55,915	5,648	2,798	342,748	121,132	23,843	2,898	2,482	2,162	7,044	.258	.324	.396	.720
12	Guardians	4,513	4,464	.503	8,979	.497	306,570	40,949	80,189	14,792	1,555	8,666	38,714	29,778	2,597	54,831	5,868	2,733	344,208	124,089	25,013	2,534	2,729	1,992	7,119	.262	.329	.405	.734
13	Phillies	4,496	4,502	.500	9,002	.500	306,866	39,732	78,433	14,778	2,045	8,430	37,519	30,394	2,586	60,810	6,028	2,277	345,494	122,591	25,253	3,200	2,448	2,963	6,339	.256	.325	.399	.725
14	Mets	4,488	4,503	.499	8,994	.501	304,607	38,137	76,757	14,043	1,604	8,039	36,004	29,776	2,631	58,572	5,644	2,439	342,998	118,125	23,686	3,562	2,422	2,861	6,695	.252	.322	.388	.709
15	Orioles	4,452	4,526	.496	8,982	.504	306,717	40,657	79,216	14,490	1,303	9,714	38,599	29,931	2,576	56,248	4,782	2,187	343,942	125,454	25,507	2,198	2,520	1,974	7,211	.258	.327	.409	.736
16	Giants	4,425	4,577	.492	9,003	.508	305,708	39,078	77,663	14,229	1,956	8,126	36,773	30,384	2,426	59,165	5,235	2,534	344,731	120,182	24,311	3,776	2,437	3,236	6,637	.254	.324	.393	.717
17	Reds	4,424	4,573	.492	9,004	.508	305,668	40,214	78,311	14,760	1,709	8,963	37,915	30,509	2,652	61,633	7,046	2,718	344,841	123,378	25,432	3,568	2,444	2,810	6,416	.256	.327	.404	.730
18	Athletics	4,390	4,607	.488	8,997	.512	304,879	40,630	76,785	14,114	1,404	9,221	38,335	31,774	2,661	58,847	6,257	2,622	344,269	121,370	24,739	2,379	2,576	1,819	6,871	.252	.325	.398	.723
19	Astros	4,381	4,619	.487	9,002	.513	305,951	39,358	78,606	14,721	1,901	7,948	37,120	29,324	2,677	57,519	6,770	2,868	343,918	120,973	24,570	3,474	2,492	2,758	6,640	.257	.325	.395	.720
20	Braves	4,302	4,682	.479	8,990	.521	305,686	39,955	78,608	14,160	1,484	9,093	37,811	29,960	2,248	57,787	4,966	2,498	343,855	123,015	24,737	3,659	2,302	2,777	6,889	.257	.326	.402	.728
21	Cardinals	4,263	4,727	.474	8,998	.526	306,255	39,911	80,072	14,734	1,978	7,463	37,606	29,584	2,558	56,169	6,832	2,858	344,549	121,151	24,175	3,595	2,557	2,985	6,820	.261	.329	.396	.725
22	Red Sox	4,145	4,849	.461	8,995	.539	310,736	44,341	83,990	17,185	1,685	9,540	42,066	31,591	2,733	56,023	4,205	2,032	349,880	133,165	28,410	2,054	2,766	2,398	7,585	.270	.340	.429	.769
23	Dodgers	4,054	4,945	.450	9,002	.550	305,956	39,537	78,847	13,649	1,641	8,542	37,369	29,851	2,372	57,278	6,219	2,633	344,608	121,404	23,832	3,971	2,458	2,964	6,507	.258	.326	.397	.723
24	Mariners	4,019	3,688	.521	7,709	.479	262,956	34,272	67,531	12,586	1,265	7,901	32,562	24,917	2,412	50,712	5,130	2,192	294,350	106,350	21,752	1,962	2,103	1,687	5,754	.257	.324	.404	.729
25	Yankees	3,932	5,053	.438	8,990	.562	307,331	43,610	81,215	14,539	1,425	10,143	41,463	32,499	2,660	54,732	5,466	2,256	347,155	129,033	26,107	1,947	2,718	2,203	7,364	.264	.337	.420	.757