The Cleveland Indians, the Seattle Mariners and the Colorado Rockies were tied for the most runs in May 2001, with 172 runs.

	TEAM	R	MONTH	G	W%	W	L	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Indians	172	May 2001	27	.704	19	8	941	292	59	6	44	169	99	9	172	10	10	1,073	495	109	8	16	4	33	.310	.376	.526	.902
2	Mariners	172	May 2001	27	.741	20	7	963	277	54	6	26	162	114	11	166	38	6	1,105	421	86	5	12	11	9	.288	.365	.437	.803
3	Rockies	172	May 2001	29	.448	13	16	1,031	295	69	8	32	165	107	15	190	29	8	1,173	476	109	14	6	15	14	.286	.360	.462	.821
4	Padres	154	May 2001	28	.607	17	11	955	246	47	4	36	146	123	7	217	32	7	1,097	409	87	6	6	4	20	.258	.345	.428	.773
5	Tigers	147	May 2001	27	.519	14	13	979	277	58	11	25	140	88	6	185	22	10	1,087	432	94	7	7	5	20	.283	.344	.441	.785
6	Giants	146	May 2001	29	.483	14	15	1,014	267	52	10	45	140	122	9	206	11	6	1,175	474	107	14	16	15	18	.263	.343	.467	.810
7	Athletics	146	May 2001	27	.667	18	9	954	258	59	2	28	139	112	19	167	14	6	1,104	405	89	6	13	13	24	.270	.354	.425	.779
8	Brewers	141	May 2001	28	.536	15	13	938	229	52	5	32	138	81	11	248	6	6	1,048	387	89	12	6	8	10	.244	.310	.413	.722
9	Phillies	138	May 2001	28	.714	20	8	953	262	60	5	31	130	107	6	190	33	7	1,088	425	96	12	10	8	22	.275	.349	.446	.794
10	Cardinals	138	May 2001	28	.607	17	11	932	251	44	6	36	133	107	11	199	13	6	1,078	415	86	19	9	14	19	.269	.348	.445	.794
11	Astros	135	May 2001	27	.519	14	13	941	245	47	4	37	128	98	10	192	11	11	1,071	411	88	13	9	3	13	.260	.334	.437	.770
12	Rangers	134	May 2001	27	.296	8	19	928	248	55	6	40	126	103	11	167	8	5	1,051	435	101	1	8	4	29	.267	.345	.469	.814
13	Blue Jays	134	May 2001	28	.357	10	18	988	249	50	4	39	127	69	12	215	21	9	1,080	424	93	6	5	11	19	.252	.307	.429	.736
14	Angels	131	May 2001	27	.519	14	13	963	269	51	3	24	125	104	15	137	26	8	1,107	398	78	12	13	9	21	.279	.354	.413	.768
15	Royals	131	May 2001	28	.357	10	18	1,009	292	61	11	16	126	60	6	164	13	9	1,096	423	88	5	16	7	24	.289	.328	.419	.747
16	Orioles	130	May 2001	26	.462	12	14	864	222	45	2	21	125	84	20	137	21	9	983	334	68	5	10	2	20	.257	.333	.387	.720
17	Cubs	126	May 2001	27	.593	16	11	890	229	39	3	30	118	92	12	189	4	9	1,023	364	72	20	9	7	22	.257	.332	.409	.741
18	Twins	123	May 2001	27	.593	16	11	955	254	54	6	22	112	90	13	181	30	12	1,064	386	82	2	4	8	20	.266	.336	.404	.740
19	Marlins	121	May 2001	28	.536	15	13	952	252	46	6	27	117	74	14	216	19	9	1,054	391	79	9	5	8	27	.265	.325	.411	.736
20	Yankees	120	May 2001	25	.600	15	10	888	232	46	2	22	110	82	11	180	28	7	990	348	70	3	6	6	16	.261	.329	.392	.721
21	Expos	120	May 2001	29	.345	10	19	945	241	64	6	25	108	81	9	208	18	6	1,062	392	95	17	10	7	30	.255	.317	.415	.732
22	Red Sox	118	May 2001	26	.500	13	13	906	247	56	9	28	114	63	9	179	7	2	987	405	93	4	5	10	22	.273	.325	.447	.772
23	Mets	117	May 2001	29	.414	12	17	967	238	56	2	23	112	96	10	200	12	11	1,088	367	81	7	8	7	26	.246	.318	.380	.698
24	Dodgers	116	May 2001	28	.536	15	13	922	226	38	5	29	112	96	6	195	15	12	1,037	361	72	7	6	5	23	.245	.318	.392	.710
25	Diamondbacks	115	May 2001	28	.643	18	10	998	242	47	4	33	112	92	9	171	15	7	1,113	396	84	9	5	18	13	.242	.311	.397	.707