Roger Clemens has the most career wins against the Mariners, with 23 wins.

Interpreted as:

most regular-season wins by a player against seattle mariners

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Roger Clemens R. Clemens	23	15	.605	44	44	3.30	274	12	4	0	321.2	282	118	136	28	107	16	0	6	1,326	10	7.67	2.99	2.56	0.78	20.7	8.1	1.21	.282	3.81	7.89
2	Justin Verlander J. Verlander	22	10	.688	40	40	3.05	277	0	0	0	262.1	222	89	92	28	53	5	0	0	1,047	7	9.50	1.82	5.23	0.96	26.5	5.1	1.05	.284	3.16	7.62
3	Bartolo Colon B. Colon	22	12	.647	41	40	3.94	168	3	1	0	258.0	249	113	123	25	52	6	0	3	1,065	6	5.86	1.81	3.23	0.87	15.8	4.9	1.17	.275	4.29	8.69
4	Dave Stewart D. Stewart	20	6	.769	32	28	3.75	124	4	2	0	204.0	179	85	86	25	81	7	3	2	856	9	5.47	3.57	1.53	1.10	14.5	9.5	1.27	.249	3.79	7.90
5	Mike Mussina M. Mussina	19	6	.760	30	29	3.84	173	2	0	0	199.1	197	85	91	26	43	2	0	0	815	2	7.81	1.94	4.02	1.17	21.2	5.3	1.20	.299	4.11	8.89
6	Chuck Finley C. Finley	19	8	.704	36	31	2.81	180	9	2	0	227.1	174	71	81	19	105	3	2	1	929	10	7.13	4.16	1.71	0.75	19.4	11.3	1.23	.249	3.21	6.89
7	Frank Tanana F. Tanana	18	13	.581	41	41	3.13	164	6	4	0	284.2	264	99	110	29	82	6	0	7	1,172	9	5.19	2.59	2.00	0.92	14.0	7.0	1.22	.264	3.48	8.35
8	Jack Morris J. Morris	17	11	.607	38	38	3.96	189	9	2	0	270.2	265	119	130	37	102	3	0	4	1,153	14	6.28	3.39	1.85	1.23	16.4	8.8	1.36	.277	4.32	8.81
9	C.J. Wilson	16	9	.640	61	24	3.35	167	2	0	7	188.0	157	70	79	14	72	9	18	1	784	12	7.99	3.45	2.32	0.67	21.3	9.2	1.22	.274	3.78	7.52
10	Kevin Appier K. Appier	16	8	.667	31	31	3.39	133	4	1	0	199.0	169	75	82	18	81	9	0	4	841	6	6.02	3.66	1.64	0.81	15.8	9.6	1.26	.252	3.71	7.64
11	Mike Flanagan M. Flanagan	16	7	.696	43	31	2.92	120	8	3	1	234.0	204	76	78	18	61	3	4	3	939	4	4.62	2.35	1.97	0.69	12.8	6.5	1.13	.252	3.00	7.85
12	CC Sabathia	15	6	.714	30	30	2.67	183	2	1	0	195.2	179	58	61	17	51	7	0	2	804	6	8.42	2.35	3.59	0.78	22.8	6.3	1.18	.297	2.81	8.23
13	John Lackey J. Lackey	15	11	.577	32	32	3.86	155	4	4	0	205.1	232	88	102	13	45	7	0	4	879	13	6.79	1.97	3.44	0.57	17.6	5.1	1.35	.332	4.47	10.17
14	Dave Stieb D. Stieb	15	9	.625	31	28	3.95	109	6	3	2	198.0	186	87	94	20	72	5	2	0	825	0	4.95	3.27	1.51	0.91	13.2	8.7	1.30	.268	4.27	8.45
15	Dennis Martinez D. Martinez	15	6	.714	27	26	3.92	72	6	1	0	170.0	180	74	81	17	43	3	1	1	714	2	3.81	2.28	1.67	0.90	10.1	6.0	1.31	.282	4.29	9.53
16	Jered Weaver J. Weaver	14	12	.538	34	34	3.46	160	2	1	0	213.1	213	82	85	25	50	6	0	1	883	7	6.75	2.11	3.20	1.05	18.1	5.7	1.23	.293	3.59	8.99
17	Tom Gordon T. Gordon	14	5	.737	44	18	2.98	128	3	1	4	145.0	95	48	52	13	75	2	12	3	604	10	7.94	4.66	1.71	0.81	21.2	12.4	1.17	.212	3.23	5.90
18	Storm Davis S. Davis	14	7	.667	32	19	4.47	81	5	1	1	139.0	149	69	74	14	53	1	4	4	602	8	5.24	3.43	1.53	0.91	13.5	8.8	1.45	.298	4.79	9.65
19	Mike Witt M. Witt	14	7	.667	30	28	2.69	144	12	2	1	210.2	179	63	68	13	70	11	2	4	860	6	6.15	2.99	2.06	0.56	16.7	8.1	1.18	.267	2.91	7.65
20	Bert Blyleven B. Blyleven	14	7	.667	27	26	2.86	129	7	5	0	192.0	181	61	68	13	49	7	0	4	790	4	6.05	2.30	2.63	0.61	16.3	6.2	1.20	.284	3.19	8.48
21	Derek Holland D. Holland	13	6	.684	29	24	3.63	144	1	1	0	158.2	147	64	69	21	50	2	0	2	663	2	8.17	2.84	2.88	1.19	21.7	7.5	1.24	.283	3.91	8.34
22	Ervin Santana E. Santana	13	9	.591	33	32	4.20	138	0	0	0	201.1	192	94	97	23	73	10	0	8	863	8	6.17	3.26	1.89	1.03	16.0	8.5	1.32	.273	4.34	8.58
23	Tim Hudson T. Hudson	13	7	.650	25	25	3.24	100	2	1	0	166.2	169	60	64	12	59	6	0	5	703	6	5.40	3.19	1.69	0.65	14.2	8.4	1.37	.298	3.46	9.13
24	Pedro Martinez P. Martinez	13	1	.929	14	13	1.57	137	2	1	0	103.0	63	18	18	6	25	5	1	0	390	0	11.97	2.18	5.48	0.52	35.1	6.4	0.85	.263	1.57	5.50
25	Jimmy Key J. Key	13	9	.591	38	30	4.79	109	2	1	0	186.0	203	99	104	25	58	1	1	1	795	5	5.27	2.81	1.88	1.21	13.7	7.3	1.40	.296	5.03	9.82

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StatMuse has game-level data for pitcher wins going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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DATE	MATCHUP			TIME (ET)
Thu 3/26	BOS	@	CIN	4:10 PM
Sat 3/28	BOS	@	CIN	4:10 PM
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Phillies - y	96	66	.593
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Braves	76	86	.469	20.0
Nationals	66	96	.407	30.0
NL Central	W	L	PCT	GB
Brewers - y	97	65	.599
Cubs - w	92	70	.568	5.0
Reds - w	83	79	.512	14.0
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Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Roger Clemens has the most career wins against the Mariners, with 23 wins.

Interpreted as:

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