Since 2000, Mark Buehrle has the most wins against the Twins, with 30 wins.

Interpreted as:

most regular-season wins by a player against twins since 2000

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Mark Buehrle M. Buehrle	30	19	.612	54	52	3.68	205	6	1	0	357.0	377	146	168	34	69	9	0	5	1,480	4	5.17	1.74	2.97	0.86	13.9	4.7	1.25	.295	4.24	9.50
2	Justin Verlander J. Verlander	22	10	.688	40	40	2.76	268	2	0	0	267.2	221	82	90	16	80	5	0	4	1,084	13	9.01	2.69	3.35	0.54	24.7	7.4	1.12	.287	3.03	7.43
3	CC Sabathia	20	10	.667	40	40	3.24	215	4	2	0	266.1	241	96	113	24	84	15	0	3	1,115	2	7.27	2.84	2.56	0.81	19.3	7.5	1.22	.279	3.82	8.14
4	Rick Porcello R. Porcello	13	11	.542	33	33	3.89	133	0	0	0	196.2	200	85	102	23	55	6	0	3	835	3	6.09	2.52	2.42	1.05	15.9	6.6	1.30	.286	4.67	9.15
5	Chris Sale C. Sale	12	6	.667	32	24	3.73	201	0	0	2	154.1	137	64	68	11	35	13	2	1	639	6	11.72	2.04	5.74	0.64	31.5	5.5	1.11	.332	3.97	7.99
6	David Price D. Price	11	4	.733	21	18	2.56	123	2	0	0	126.2	102	36	38	7	29	0	0	0	501	2	8.74	2.06	4.24	0.50	24.6	5.8	1.03	.278	2.70	7.25
7	Paul Byrd P. Byrd	11	5	.688	20	20	3.92	53	2	1	0	131.0	134	57	66	14	30	4	0	2	550	2	3.64	2.06	1.77	0.96	9.6	5.5	1.25	.267	4.53	9.21
8	Corey Kluber C. Kluber	10	8	.556	26	25	3.77	173	2	0	1	164.2	137	69	75	21	41	12	1	2	674	5	9.46	2.24	4.22	1.15	25.7	6.1	1.08	.272	4.10	7.49
9	Max Scherzer M. Scherzer	10	3	.769	20	20	4.70	128	0	0	0	120.2	105	63	63	16	38	3	0	0	498	8	9.55	2.83	3.37	1.19	25.7	7.6	1.19	.284	4.70	7.83
10	Lucas Giolito L. Giolito	9	10	.474	25	25	4.13	141	1	1	0	141.2	110	65	68	24	56	7	0	0	584	7	8.96	3.56	2.52	1.52	24.1	9.6	1.17	.242	4.32	6.99
11	Matthew Boyd M. Boyd	9	8	.529	24	24	4.67	139	1	0	0	135.0	111	70	75	26	43	11	0	0	554	7	9.27	2.87	3.23	1.73	25.1	7.8	1.14	.254	5.00	7.40
12	Carlos Rodón C. Rodón	9	4	.692	16	15	3.93	97	0	0	0	89.1	78	39	41	10	31	3	0	1	371	6	9.77	3.12	3.13	1.01	26.1	8.4	1.22	.296	4.13	7.86
13	Jose Quintana J. Quintana	9	8	.529	23	23	3.76	130	0	0	0	138.2	136	58	66	12	41	3	0	0	582	6	8.44	2.66	3.17	0.78	22.3	7.0	1.28	.313	4.28	8.83
14	Danny Duffy D. Duffy	9	3	.750	28	24	3.15	125	0	0	0	145.2	132	51	55	19	50	0	1	1	602	3	7.72	3.09	2.50	1.17	20.8	8.3	1.25	.277	3.40	8.16
15	Jason Vargas J. Vargas	9	4	.692	21	19	3.83	64	0	0	0	112.2	124	48	51	11	33	1	1	0	486	1	5.11	2.64	1.94	0.88	13.2	6.8	1.39	.300	4.07	9.91
16	Jered Weaver J. Weaver	9	3	.750	18	18	3.62	98	1	1	0	119.1	99	48	49	13	31	2	0	0	481	0	7.39	2.34	3.16	0.98	20.4	6.4	1.09	.255	3.70	7.47
17	James Shields J. Shields	9	10	.474	27	27	4.35	124	0	0	0	165.2	170	80	93	23	65	5	0	2	725	9	6.74	3.53	1.91	1.25	17.1	9.0	1.42	.289	5.05	9.24
18	Jeremy Guthrie J. Guthrie	9	4	.692	18	16	3.41	73	1	1	0	111.0	104	42	43	13	29	9	0	0	467	2	5.92	2.35	2.52	1.05	15.6	6.2	1.20	.265	3.49	8.43
19	Nate Robertson N. Robertson	9	11	.450	26	24	4.22	98	1	0	0	151.1	162	71	80	18	51	6	0	1	659	4	5.83	3.03	1.92	1.07	14.9	7.7	1.41	.296	4.76	9.63
20	Cliff Lee C. Lee	9	4	.692	20	20	3.58	102	0	0	0	123.1	115	49	51	9	38	5	0	0	509	5	7.44	2.77	2.68	0.66	20.0	7.5	1.24	.299	3.72	8.39
21	John Lackey J. Lackey	9	6	.600	19	19	3.05	100	0	0	0	132.2	120	45	58	14	26	5	0	1	536	9	6.78	1.76	3.85	0.95	18.7	4.9	1.10	.271	3.93	8.14
22	Freddy Garcia F. Garcia	9	8	.529	22	22	4.33	82	2	0	0	143.1	145	69	72	19	37	7	0	3	603	3	5.15	2.32	2.22	1.19	13.6	6.1	1.27	.275	4.52	9.10
23	Tim Wakefield T. Wakefield	9	5	.643	19	17	4.38	75	1	0	1	109.0	109	53	65	12	32	3	1	1	464	7	6.19	2.64	2.34	0.99	16.2	6.9	1.29	.284	5.37	9.00
24	Felix Hernandez F. Hernandez	8	6	.571	18	18	2.26	116	2	2	0	127.1	90	32	33	4	27	3	0	0	494	6	8.20	1.91	4.30	0.28	23.5	5.5	0.92	.250	2.33	6.36
25	Roy Halladay R. Halladay	8	2	.800	12	12	2.79	74	2	1	0	90.1	81	28	32	7	10	3	0	0	358	1	7.37	1.00	7.40	0.70	20.7	2.8	1.01	.280	3.19	8.07

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StatMuse has game-level data for pitcher wins going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Mon 5/4	CWS	@	LAA	9:38 PM
Tue 5/5	CWS	@	LAA	9:38 PM
Wed 5/6	CWS	@	LAA	4:07 PM
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Braves	25	10	.714
Marlins	16	18	.471	8.5
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Phillies	14	20	.412	10.5
Mets	12	22	.353	12.5
NL Central	W	L	PCT	GB
Cubs	22	12	.647
Reds	20	14	.588	2.0
Cardinals	20	14	.588	2.0
Brewers	18	15	.545	3.5
Pirates	19	16	.543	3.5
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Sun 4/19	SFG	@	WSH	0-3
Sun 4/19	KCR	@	NYY	0-7
Sun 4/19	BAL	@	CLE	4-8

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Mon 5/4	NYM	@	COL	5:40 PM
Mon 5/4	BOS	@	DET	6:40 PM
Mon 5/4	TOR	@	TBR	6:40 PM
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Since 2000, Mark Buehrle has the most wins against the Twins, with 30 wins.

Interpreted as:

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