Between the 1921 and 1964 seasons, Warren Spahn won the most games, with 356 wins.

Interpreted as:

most regular-season wins by a player between 1921 to 1964

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Warren Spahn W. Spahn	356	229	.609	714	635	3.05	2,493	374	63	28	5046.0	4,620	1,710	1,912	408	1,378	39	64	58	20,701	79	4.45	2.46	1.81	0.73	12.0	6.7	1.19	.257	3.41	83	3.41	93	8.24	142.4
2	Early Wynn E. Wynn	300	244	.551	691	611	3.54	2,334	289	49	16	4564.0	4,291	1,796	2,037	338	1,775	64	67	36	19,408	51	4.60	3.50	1.31	0.67	12.0	9.1	1.33	.265	4.02	94	3.64	97	8.46	56.4
3	Lefty Grove L. Grove	300	141	.680	616	457	3.06	2,266	298	35	54	3940.2	3,849	1,339	1,594	162	1,187	42	123		16,622	51	5.18	2.71	1.91	0.37	13.6	7.1	1.28	.284	3.64	68	3.36	76	8.79	462.8
4	Red Ruffing R. Ruffing	273	225	.548	624	538	3.80	1,987	335	45	18	4344.0	4,284	1,833	2,115	254	1,541	58	69		18,546	46	4.12	3.19	1.29	0.53	10.7	8.3	1.34	.274	4.38	91	3.93	95	8.88	82.3
5	Robin Roberts R. Roberts	271	228	.543	622	563	3.40	2,206	295	41	24	4386.0	4,270	1,655	1,823	472	851	52	44	65	17,928	29	4.53	1.75	2.59	0.97	12.3	4.7	1.17	.265	3.74	88	3.50	91	8.76	180.2
6	Bob Feller B. Feller	266	162	.621	570	484	3.25	2,581	279	44	22	3827.0	3,271	1,384	1,557	224	1,764	60	52	6	16,180	69	6.07	4.15	1.46	0.53	16.0	10.9	1.32	.264	3.66	82	3.48	89	7.69	184.6
7	Ted Lyons T. Lyons	260	230	.531	594	484	3.67	1,073	356	27	25	4161.0	4,489	1,696	2,056	222	1,121	31	91		17,797	55	2.32	2.42	0.96	0.48	6.0	6.3	1.35	.278	4.45	85	4.01	95	9.71	91.7
8	Carl Hubbell C. Hubbell	253	154	.622	535	433	2.98	1,677	260	36	33	3590.1	3,461	1,188	1,380	227	725	53	82		14,805	53	4.20	1.82	2.31	0.57	11.3	4.9	1.17	.267	3.46	76	3.55	89	8.68	174.2
9	Waite Hoyt W. Hoyt	227	170	.572	638	403	3.57	1,131	214	23	52	3534.2	3,815	1,403	1,666	151	934	48	160		15,103	35	2.88	2.38	1.21	0.38	7.5	6.2	1.34	.285	4.24	88	3.81	93	9.71	99.6
10	Paul Derringer P. Derringer	223	212	.513	579	445	3.46	1,507	251	32	29	3645.0	3,912	1,401	1,652	158	761	32	98		15,391	50	3.72	1.88	1.98	0.39	9.8	4.9	1.28	.290	4.08	93	3.26	86	9.66	218.5
11	Mel Harder M. Harder	223	186	.545	582	433	3.80	1,161	181	25	24	3426.1	3,706	1,447	1,714	161	1,118	59	94		14,861	33	3.05	2.94	1.04	0.42	7.8	7.5	1.41	.287	4.50	90	3.87	94	9.73	113.2
12	Earl Whitehill E. Whitehill	218	185	.541	541	473	4.36	1,350	226	16	11	3564.2	3,917	1,726	2,018	192	1,431	101	46		15,781	43	3.41	3.61	0.94	0.48	8.6	9.1	1.50	.293	5.10	99	4.29	99	9.89	6
13	Freddie Fitzsimmons F. Fitzsimmons	217	146	.598	513	424	3.51	870	186	30	13	3223.2	3,335	1,257	1,505	187	846	33	65		13,570	58	2.43	2.36	1.03	0.52	6.4	6.2	1.30	.271	4.20	90	4.06	102	9.31	-24.3
14	Whitey Ford W. Ford	216	84	.720	432	386	2.73	1,730	145	42	10	2809.0	2,406	851	966	196	1,003	27	27	36	11,545	65	5.54	3.21	1.72	0.63	15.0	8.7	1.21	.257	3.10	73	3.28	88	7.71	143.1
15	Burleigh Grimes B. Grimes	213	162	.568	468	391	3.79	1,094	245	21	15	3185.1	3,526	1,341	1,638	132	1,012	80	58		13,853	59	3.09	2.86	1.08	0.37	7.9	7.3	1.42	.294	4.63	95	3.93	97	9.96	45.2
16	Billy Pierce B. Pierce	211	169	.555	585	433	3.27	1,999	193	38	33	3306.2	2,989	1,201	1,325	284	1,178	30	85	35	13,853	48	5.44	3.21	1.70	0.77	14.4	8.5	1.26	.261	3.61	84	3.50	90	8.14	138.6
17	Bobo Newsom B. Newsom	211	222	.487	600	483	3.98	2,082	246	31	21	3759.1	3,769	1,664	1,908	206	1,732	61	71		16,467	60	4.98	4.15	1.20	0.49	12.6	10.5	1.46	.288	4.57	95	3.81	92	9.02	144.5
18	Bob Lemon B. Lemon	207	128	.618	460	350	3.23	1,277	188	31	22	2850.0	2,559	1,024	1,185	180	1,251	57	73	13	12,099	63	4.03	3.95	1.02	0.57	10.6	10.3	1.34	.255	3.74	84	3.79	99	8.08	7.5
19	Hal Newhouser H. Newhouser	207	150	.580	488	374	3.06	1,796	212	33	26	2993.0	2,674	1,016	1,197	136	1,249	19	79	1	12,648	65	5.40	3.76	1.44	0.41	14.2	9.9	1.31	.269	3.60	76	3.19	80	8.04	244.2
20	Charlie Root C. Root	201	160	.557	632	341	3.59	1,459	177	21	42	3197.1	3,252	1,274	1,467	189	889	79	186		13,529	22	4.11	2.50	1.64	0.53	10.8	6.6	1.30	.281	4.13	91	3.79	94	9.15	86.7
21	Bucky Walters B. Walters	198	160	.553	428	398	3.30	1,107	242	42	4	3104.2	2,990	1,139	1,343	155	1,121	51	18		13,140	63	3.21	3.25	0.99	0.45	8.4	8.5	1.32	.265	3.89	87	3.82	99	8.67	15.3
22	Larry French L. French	197	171	.535	570	383	3.44	1,187	199	40	17	3152.0	3,375	1,206	1,440	164	819	42	108		13,465	34	3.39	2.34	1.45	0.47	8.8	6.1	1.33	.285	4.11	87	3.76	93	9.64	101.2
23	Dazzy Vance D. Vance	197	136	.592	431	345	3.22	2,027	216	29	12	2933.2	2,774	1,050	1,224	131	817	74	47		12,220	36	6.22	2.51	2.48	0.40	16.6	6.7	1.22	.288	3.76	80	3.17	78	8.51	292.4
24	Jesse Haines J. Haines	197	138	.588	507	350	3.71	859	190	19	9	2902.0	3,152	1,197	1,419	156	790	48	86		12,366	50	2.66	2.45	1.09	0.48	6.9	6.4	1.36	.285	4.40	91	4.03	98	9.78	26
25	Tommy Bridges T. Bridges	194	138	.584	424	362	3.57	1,674	200	33	10	2826.1	2,675	1,122	1,321	181	1,192	35	47		12,165	59	5.33	3.80	1.40	0.58	13.8	9.8	1.37	.275	4.21	80	3.88	89	8.52	154.4