Between the 1980 and 2022 seasons, Greg Maddux won the most games, with 355 wins.

Interpreted as:

most regular-season wins by a pitcher 1980 to 2022

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Greg Maddux G. Maddux	355	227	.610	744	740	3.16	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
2	Roger Clemens R. Clemens	354	184	.658	709	707	3.12	4,672	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
3	Tom Glavine T. Glavine	305	203	.600	682	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
4	Randy Johnson R. Johnson	303	166	.646	618	603	3.29	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
5	Mike Mussina M. Mussina	270	153	.638	537	536	3.68	2,813	57	23	0	3562.2	3,460	1,458	1,559	376	785	60	0	29	14,593	71	7.11	1.98	3.58	0.95	19.3	5.4	1.19	.292	3.94	82	3.57	79	8.74	372.8
6	Jamie Moyer J. Moyer	269	209	.563	696	638	4.25	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
7	Andy Pettitte A. Pettitte	256	153	.626	531	521	3.85	2,448	26	4	0	3316.0	3,448	1,418	1,572	288	1,031	55	3	42	14,074	69	6.64	2.80	2.37	0.78	17.4	7.3	1.35	.308	4.27	86	3.73	83	9.36	282.1
8	CC Sabathia	251	161	.609	561	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
9	Bartolo Colon B. Colon	247	188	.568	565	552	4.12	2,535	38	13	0	3461.2	3,593	1,584	1,719	439	948	64	2	47	14,655	45	6.59	2.46	2.67	1.14	17.3	6.5	1.31	.296	4.47	95	4.14	96	9.34	71.6
10	Justin Verlander J. Verlander	244	133	.647	482	482	3.24	3,198	26	9	0	3163.0	2,654	1,139	1,235	322	880	104	0	27	12,880	90	9.10	2.50	3.63	0.92	24.8	6.8	1.12	.278	3.51	76	3.35	79	7.55	308.2
11	David Wells D. Wells	239	157	.604	660	489	4.13	2,201	54	12	13	3439.0	3,635	1,578	1,702	407	719	83	65	65	14,413	101	5.76	1.88	3.06	1.07	15.3	5.0	1.27	.293	4.45	93	3.99	90	9.51	172.9
12	Jack Morris J. Morris	233	173	.574	487	487	3.92	2,289	165	27	0	3474.2	3,243	1,515	1,662	358	1,259	51	0	90	14,656	191	5.93	3.26	1.82	0.93	15.6	8.6	1.30	.270	4.30	96	3.93	95	8.40	82.5
13	Zack Greinke Z. Greinke	223	141	.613	556	514	3.42	2,882	17	5	1	3247.0	3,049	1,235	1,328	342	739	75	8	25	13,284	99	7.99	2.05	3.90	0.95	21.7	5.6	1.17	.293	3.68	81	3.46	84	8.45	242.3
14	Tim Hudson T. Hudson	222	133	.625	482	479	3.49	2,080	26	13	0	3126.2	2,957	1,213	1,319	248	917	124	0	84	13,005	84	5.99	2.64	2.27	0.71	16.0	7.1	1.24	.281	3.80	83	3.78	90	8.51	152.3
15	Pedro Martinez P. Martinez	219	100	.687	476	409	2.93	3,154	46	17	3	2827.1	2,221	919	1,006	239	760	141	23	30	11,394	62	10.04	2.42	4.15	0.76	27.7	6.7	1.05	.279	3.20	66	2.91	68	7.07	454.6
16	Kenny Rogers K. Rogers	219	156	.584	762	474	4.27	1,968	36	9	28	3302.2	3,457	1,568	1,739	339	1,175	127	133	53	14,280	79	5.36	3.20	1.67	0.92	13.8	8.2	1.40	.292	4.74	93	4.38	97	9.42	43.3
17	Curt Schilling C. Schilling	216	146	.597	569	436	3.46	3,116	83	20	22	3261.0	2,998	1,253	1,318	347	711	52	81	43	13,284	72	8.60	1.96	4.38	0.96	23.5	5.4	1.14	.293	3.64	80	3.22	76	8.27	373.6
18	Mark Buehrle M. Buehrle	214	160	.572	518	493	3.81	1,870	33	10	0	3283.1	3,472	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
19	John Smoltz J. Smoltz	213	155	.579	723	481	3.33	3,084	53	16	154	3473.0	3,074	1,284	1,391	288	1,010	57	204	84	14,271	145	7.99	2.62	3.05	0.75	21.6	7.1	1.18	.283	3.60	81	3.23	78	7.97	356.6
20	Kevin Brown K. Brown	211	144	.594	486	476	3.28	2,397	72	17	0	3256.1	3,079	1,185	1,357	208	901	139	1	42	13,542	108	6.62	2.49	2.66	0.57	17.7	6.7	1.22	.290	3.75	78	3.32	78	8.51	344.2
21	Orel Hershiser O. Hershiser	204	150	.576	510	466	3.48	2,014	68	25	5	3130.1	2,939	1,211	1,366	235	1,007	117	19	108	13,150	121	5.79	2.90	2.00	0.68	15.3	7.7	1.26	.277	3.93	89	3.68	93	8.45	84.8
22	Roy Halladay R. Halladay	203	105	.659	416	390	3.38	2,117	67	20	1	2749.1	2,646	1,034	1,135	236	592	81	6	28	11,287	56	6.93	1.94	3.58	0.77	18.8	5.2	1.18	.292	3.72	77	3.39	77	8.66	296
23	Max Scherzer M. Scherzer	201	102	.663	430	421	3.11	3,193	12	5	0	2682.0	2,180	927	998	300	701	107	2	20	10,831	74	10.71	2.35	4.55	1.01	29.5	6.5	1.07	.288	3.35	75	3.09	75	7.32	309.9
24	Jon Lester J. Lester	200	117	.631	452	451	3.66	2,488	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
25	Tim Wakefield T. Wakefield	200	180	.526	627	463	4.41	2,156	33	6	22	3226.1	3,152	1,582	1,791	418	1,205	186	78	33	13,939	134	6.01	3.36	1.79	1.17	15.5	8.6	1.35	.274	5.00	96	4.72	108	8.79	-137.5