Warren Spahn has won the most career games by a pitcher 25 or older, with 363 wins.

Interpreted as:

most regular-season wins by a pitcher after turning 25 years old

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Warren Spahn W. Spahn	363	245	.597	746	663	3.08	2,576	381	63	28	5228.0	4,808	1,791	2,003	434	1,421	41	67		21,476	78	4.43	2.45	1.81	0.75	12.0	6.6	1.19	.257	3.45	8.28
2	Grover Alexander G. Alexander	345	195	.639	648	563	2.56	1,979	406	83	30	4817.2	4,581		1,718	160	822	59	69			34	3.70	1.54	2.41	0.30		4.2	1.12	.269	3.21	8.56
3	Phil Niekro P. Niekro	318	274	.537	864	716	3.35	3,342	245	45	29	5404.0	5,044	2,012	2,337	482	1,809	123	83	86	22,677	227	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	8.40
4	Gaylord Perry G. Perry	310	258	.546	735	679	3.07	3,464	302	53	8	5235.0	4,800	1,787	2,058	386	1,337	106	26	155	21,431	154	5.96	2.30	2.59	0.66	16.2	6.2	1.17	.274	3.54	8.25
5	Randy Johnson R. Johnson	303	166	.646	618	603	3.29	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	7.28
6	Roger Clemens R. Clemens	303	164	.649	617	616	3.12	4,090	88	38	0	4251.0	3,619	1,473	1,634	311	1,389	142	0	56	17,517	123	8.66	2.94	2.94	0.66	23.3	7.9	1.18	.286	3.46	7.66
7	Walter Johnson W. Johnson	302	189	.615	577	472	2.36	2,300	362	77	28	4191.2	3,560		1,380	84	994	140	98			77	4.94	2.13	2.31	0.18		5.9	1.09	.261	2.96	7.64
8	Lefty Grove L. Grove	300	141	.680	616	457	3.06	2,269	298	35	54	3938.1	3,848	1,341	1,596	162	1,184	41	123		16,622	51	5.19	2.71	1.92	0.37	13.7	7.1	1.28	.284	3.65	8.79
9	Nolan Ryan N. Ryan	295	254	.537	702	699	3.15	5,221	209	59	1	4876.0	3,554	1,708	1,948	287	2,451	134	3	64	20,349	254	9.64	4.52	2.13	0.53	25.7	12.0	1.23	.267	3.60	6.56
10	Greg Maddux G. Maddux	294	174	.628	603	603	3.04	2,826	83	28	0	4089.1	3,802	1,383	1,547	296	679	113	0	123	16,489	53	6.22	1.49	4.16	0.65	17.1	4.1	1.10	.279	3.40	8.37
11	Steve Carlton S. Carlton	282	210	.573	622	606	3.30	3,550	219	45	1	4479.1	4,017	1,641	1,877	373	1,591	43	6	137	18,631	157	7.13	3.20	2.23	0.75	19.1	8.5	1.25	.279	3.77	8.07
12	Don Sutton D. Sutton	273	196	.582	624	619	3.26	2,817	143	47	3	4323.0	3,829	1,564	1,729	404	1,084	68	4	67	17,680	91	5.86	2.26	2.60	0.84	15.9	6.1	1.14	.257	3.60	7.97
13	Tom Glavine T. Glavine	272	162	.627	577	577	3.41	2,284	48	21	0	3767.1	3,638	1,426	1,556	301	1,286	52	0	121	15,827	52	5.46	3.07	1.78	0.72	14.4	8.1	1.31	.280	3.72	8.69
14	Early Wynn E. Wynn	261	196	.571	583	517	3.52	2,109	243	43	13	3849.1	3,532	1,504	1,685	314	1,532	58	54		16,321	44	4.93	3.58	1.38	0.73	12.9	9.4	1.32	.261	3.94	8.26
15	Fergie Jenkins F. Jenkins	256	204	.557	558	544	3.38	2,796	245	45	1	4014.2	3,755	1,508	1,672	428	860	77	9	96	16,446	59	6.27	1.93	3.25	0.96	17.0	5.2	1.15	.271	3.75	8.42
16	Tom Seaver T. Seaver	254	173	.595	549	543	2.96	3,057	181	49	0	3980.2	3,321	1,309	1,441	322	1,182	56	3	97	16,163	105	6.91	2.67	2.59	0.73	18.9	7.3	1.13	.260	3.26	7.51
17	Red Faber R. Faber	254	213	.544	669	483	3.15	1,476	273	29	27	4088.0	4,110		1,816	112	1,221	106	134			52	3.25	2.69	1.21	0.25		7.1	1.30	.278	4.00	9.05
18	Carl Hubbell C. Hubbell	253	154	.622	535	433	2.98	1,678	260	36	33	3588.2	3,462	1,188	1,384	227	728	53	82		14,810	53	4.21	1.83	2.30	0.57	11.3	4.9	1.17	.267	3.47	8.68
19	Jamie Moyer J. Moyer	250	190	.568	645	589	4.19	2,249	31	9	0	3785.2	3,914	1,763	1,897	484	1,016	138	14	59	16,062	43	5.35	2.42	2.21	1.15	14.0	6.3	1.30	.282	4.51	9.31
20	Burleigh Grimes B. Grimes	248	186	.571	537	449	3.66	1,320	285	27	17	3699.0	4,021		1,853	141	1,148	87	68		16,020	76	3.21	2.79	1.15	0.34	8.2	7.2	1.40	.291	4.51	9.78
21	Jack Quinn J. Quinn	246	217	.531	756	443	2.80	1,342	242	28	56	3924.1	4,243		1,835	102	859	95	218			59	3.08	1.97	1.56	0.23		5.5	1.30	.313	4.21	9.73
22	Jim Kaat J. Kaat	245	189	.565	776	523	3.38	2,034	149	24	15	3827.0	3,939	1,436	1,683	327	853	77	94	107	16,028	97	4.78	2.01	2.38	0.77	12.7	5.3	1.25	.284	3.96	9.26
23	Bob Gibson B. Gibson	245	163	.600	488	461	2.84	3,000	251	55	6	3722.0	3,105	1,176	1,324	246	1,249	100	15	110	15,334	102	7.25	3.02	2.40	0.59	19.6	8.1	1.17	.266	3.20	7.51
24	Tommy John T. John	244	189	.564	617	586	3.45	1,750	132	33	1	3950.2	4,129	1,516	1,737	252	1,043	82	16	79	16,599	158	3.99	2.38	1.68	0.57	10.5	6.3	1.31	.288	3.96	9.41
25	Bartolo Colon B. Colon	240	178	.574	536	525	4.09	2,413	35	12	0	3300.0	3,425	1,501	1,624	420	876	58	2	44	13,936	37	6.58	2.39	2.75	1.15	17.3	6.3	1.30	.296	4.43	9.34