Since 1978, Greg Maddux has won the most games, with 355 wins.

Interpreted as:

most regular-season wins by a pitcher since 1978

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Greg Maddux G. Maddux	355	227	.610	744	740	3.16	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
2	Roger Clemens R. Clemens	354	184	.658	709	707	3.12	4,672	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
3	Tom Glavine T. Glavine	305	203	.600	682	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
4	Randy Johnson R. Johnson	303	166	.646	618	603	3.29	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
5	Mike Mussina M. Mussina	270	153	.638	537	536	3.68	2,813	57	23	0	3562.2	3,460	1,458	1,559	376	785	60	0	29	14,593	71	7.11	1.98	3.58	0.95	19.3	5.4	1.19	.292	3.94	82	3.57	79	8.74	372.8
6	Jamie Moyer J. Moyer	269	209	.563	696	638	4.25	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
7	Justin Verlander J. Verlander	262	149	.637	533	533	3.31	3,448	26	9	0	3452.2	2,926	1,270	1,374	360	965	115	0	27	14,102	97	8.99	2.52	3.57	0.94	24.5	6.8	1.13	.278	3.58	78	3.42	81	7.63	307.5
8	Andy Pettitte A. Pettitte	256	153	.626	531	521	3.85	2,448	26	4	0	3316.0	3,448	1,418	1,572	288	1,031	55	3	42	14,074	69	6.64	2.80	2.37	0.78	17.4	7.3	1.35	.308	4.27	86	3.73	83	9.36	282.1
9	Jack Morris J. Morris	253	185	.578	542	521	3.90	2,450	174	28	0	3778.1	3,529	1,638	1,795	385	1,367	58	10	99	15,931	204	5.84	3.26	1.79	0.92	15.4	8.6	1.30	.269	4.28	96	3.93	95	8.41	92.8
10	CC Sabathia	251	161	.609	561	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
11	Bartolo Colon B. Colon	247	188	.568	565	552	4.12	2,535	38	13	0	3461.2	3,593	1,584	1,719	439	948	64	2	47	14,655	45	6.59	2.46	2.67	1.14	17.3	6.5	1.31	.296	4.47	95	4.14	96	9.34	71.6
12	David Wells D. Wells	239	157	.604	660	489	4.13	2,201	54	12	13	3439.0	3,635	1,578	1,702	407	719	83	65	65	14,413	101	5.76	1.88	3.06	1.07	15.3	5.0	1.27	.293	4.45	93	3.99	90	9.51	172.9
13	Dennis Martinez D. Martinez	230	184	.556	646	547	3.69	2,024	116	30	4	3805.1	3,717	1,559	1,741	361	1,093	114	31	66	15,939	77	4.79	2.59	1.85	0.85	12.7	6.9	1.26	.272	4.12	94	3.93	99	8.79	7.8
14	Zack Greinke Z. Greinke	225	156	.591	586	541	3.49	2,979	17	5	1	3389.1	3,207	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
15	Tim Hudson T. Hudson	222	133	.625	482	479	3.49	2,080	26	13	0	3126.2	2,957	1,213	1,319	248	917	124	0	84	13,005	84	5.99	2.64	2.27	0.71	16.0	7.1	1.24	.281	3.80	83	3.78	90	8.51	152.3
16	Pedro Martinez P. Martinez	219	100	.687	476	409	2.93	3,154	46	17	3	2827.1	2,221	919	1,006	239	760	141	23	30	11,394	62	10.04	2.42	4.15	0.76	27.7	6.7	1.05	.279	3.20	66	2.91	68	7.07	454.6
17	Kenny Rogers K. Rogers	219	156	.584	762	474	4.27	1,968	36	9	28	3302.2	3,457	1,568	1,739	339	1,175	127	133	53	14,280	79	5.36	3.20	1.67	0.92	13.8	8.2	1.40	.292	4.74	93	4.38	97	9.42	43.3
18	Curt Schilling C. Schilling	216	146	.597	569	436	3.46	3,116	83	20	22	3261.0	2,998	1,253	1,318	347	711	52	81	43	13,284	72	8.60	1.96	4.38	0.96	23.5	5.4	1.14	.293	3.64	80	3.22	76	8.27	373.6
19	Max Scherzer M. Scherzer	215	112	.657	467	458	3.16	3,408	12	5	0	2881.0	2,349	1,012	1,085	337	756	112	2	20	11,640	78	10.65	2.36	4.51	1.05	29.3	6.5	1.08	.286	3.39	76	3.18	77	7.34	307.9
20	Mark Buehrle M. Buehrle	214	160	.572	518	493	3.81	1,870	33	10	0	3283.1	3,472	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
21	John Smoltz J. Smoltz	213	155	.579	723	481	3.33	3,084	53	16	154	3473.0	3,074	1,284	1,391	288	1,010	57	204	84	14,271	145	7.99	2.62	3.05	0.75	21.6	7.1	1.18	.283	3.60	81	3.23	78	7.97	356.6
22	Clayton Kershaw C. Kershaw	212	94	.693	432	429	2.50	2,968	25	15	0	2742.2	2,091	762	835	227	678	44	1	28	10,816	103	9.74	2.22	4.38	0.74	27.4	6.3	1.01	.270	2.74	64	2.82	70	6.86	366.8
23	Kevin Brown K. Brown	211	144	.594	486	476	3.28	2,397	72	17	0	3256.1	3,079	1,185	1,357	208	901	139	1	42	13,542	108	6.62	2.49	2.66	0.57	17.7	6.7	1.22	.290	3.75	78	3.32	78	8.51	344.2
24	Bob Welch B. Welch	211	146	.591	506	462	3.47	1,969	61	28	8	3092.0	2,894	1,191	1,310	267	1,034	79	20	60	12,956	55	5.73	3.01	1.90	0.78	15.2	8.0	1.27	.273	3.81	94	3.70	99	8.42	6.9
25	Orel Hershiser O. Hershiser	204	150	.576	510	466	3.48	2,014	68	25	5	3130.1	2,939	1,211	1,366	235	1,007	117	19	108	13,150	121	5.79	2.90	2.00	0.68	15.3	7.7	1.26	.277	3.93	89	3.68	93	8.45	84.8