Between the 2012 and 2016 seasons, the St. Louis Cardinals had the most wins by a team, with 461 wins.

Interpreted as:

most regular-season wins by an MLB team 2012 to 2016

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	461	349	.569	810	27,637	3,593	7,192	1,474	149	751	3,426	2,517	339	6,020	297	155	30,973	11,217	2,374	265	215	186	674	.260	.327	.406	.733
2	Nationals	458	352	.565	810	27,511	3,539	7,002	1,358	121	887	3,344	2,535	245	6,417	472	148	30,802	11,263	2,366	281	230	194	571	.255	.321	.409	.730
3	Dodgers	455	355	.562	810	27,392	3,396	7,014	1,387	125	764	3,229	2,564	288	6,127	424	182	30,714	10,943	2,276	279	191	186	643	.256	.324	.399	.724
4	Orioles	444	366	.548	810	27,785	3,619	7,052	1,343	72	1,107	3,473	2,183	243	6,380	244	116	30,527	11,860	2,522	137	179	131	615	.254	.312	.427	.739
5	Pirates	437	372	.540	810	27,607	3,393	6,983	1,358	161	780	3,239	2,455	387	6,584	479	231	30,917	11,003	2,299	282	186	204	593	.253	.321	.399	.719
6	Yankees	435	375	.537	810	27,495	3,531	6,907	1,291	102	931	3,363	2,512	280	5,938	455	131	30,663	11,195	2,324	141	235	122	594	.251	.318	.407	.725
7	Rangers	434	377	.535	811	27,671	3,691	7,256	1,361	138	874	3,521	2,296	325	5,785	545	224	30,709	11,515	2,373	183	234	162	606	.262	.324	.416	.740
8	Tigers	431	377	.533	808	27,972	3,718	7,640	1,437	167	856	3,575	2,433	238	5,882	341	164	30,995	11,979	2,460	132	220	205	726	.273	.334	.428	.762
9	Giants	429	381	.530	810	27,763	3,423	7,271	1,392	227	608	3,245	2,408	202	5,686	413	164	30,875	10,941	2,227	267	235	194	620	.262	.323	.394	.717
10	Angels	424	386	.523	810	27,624	3,651	7,199	1,369	133	838	3,464	2,370	264	5,741	422	174	30,689	11,348	2,340	183	248	166	663	.261	.322	.411	.733
11	Royals	423	387	.522	810	27,857	3,374	7,338	1,399	175	624	3,196	1,971	259	5,262	663	175	30,466	10,959	2,198	168	211	146	659	.263	.316	.393	.709
12	Indians	420	388	.520	808	27,488	3,527	7,017	1,451	128	775	3,363	2,685	240	5,962	551	166	30,844	11,049	2,354	177	254	121	644	.255	.324	.402	.726
13	Athletics	415	395	.512	810	27,693	3,556	6,829	1,368	157	842	3,382	2,626	212	5,933	407	132	30,823	11,037	2,367	94	198	132	589	.247	.315	.399	.713
14	Blue Jays	412	398	.509	810	27,561	3,801	7,017	1,386	105	1,013	3,616	2,687	243	6,038	455	150	30,875	11,652	2,504	159	225	103	663	.255	.324	.423	.747
15	Red Sox	408	402	.504	810	28,116	3,847	7,473	1,621	123	835	3,657	2,580	274	6,150	437	126	31,325	11,845	2,579	116	239	176	644	.266	.331	.421	.752
16	Rays	407	404	.502	811	27,418	3,325	6,791	1,375	141	840	3,180	2,572	313	6,410	417	191	30,666	10,968	2,356	138	225	130	617	.248	.317	.400	.717
17	Braves	404	405	.499	809	27,268	3,183	6,776	1,296	118	675	3,024	2,554	235	6,389	404	163	30,543	10,333	2,089	295	191	203	641	.248	.316	.379	.695
18	Mets	404	406	.499	810	27,467	3,252	6,674	1,359	108	789	3,123	2,536	277	6,490	387	150	30,699	10,616	2,256	240	179	210	589	.243	.311	.387	.698
19	Cubs	400	409	.494	810	27,411	3,326	6,669	1,397	145	836	3,160	2,551	334	6,799	383	188	30,679	10,864	2,378	216	167	178	547	.243	.314	.396	.710
20	Reds	395	415	.488	810	27,429	3,318	6,814	1,358	130	789	3,153	2,429	269	6,302	549	203	30,670	10,799	2,277	339	204	216	558	.248	.314	.394	.707
21	Mariners	395	415	.488	810	27,629	3,301	6,756	1,250	115	894	3,140	2,375	229	6,468	374	173	30,561	10,918	2,259	155	173	135	590	.245	.308	.395	.703
22	Brewers	380	430	.469	810	27,303	3,392	6,866	1,358	163	848	3,233	2,307	312	6,462	667	217	30,433	11,094	2,369	331	180	158	623	.251	.315	.406	.721
23	White Sox	375	435	.463	810	27,707	3,314	7,003	1,281	140	818	3,176	2,148	277	6,288	444	199	30,463	11,018	2,239	128	203	118	610	.253	.311	.398	.708
24	Diamondbacks	374	436	.462	810	28,004	3,506	7,236	1,442	215	757	3,319	2,409	210	6,312	510	200	31,098	11,379	2,414	256	219	212	634	.258	.320	.406	.726
25	Padres	371	439	.458	810	27,109	3,140	6,486	1,259	161	701	2,965	2,349	245	6,668	571	188	30,153	10,170	2,121	259	191	151	518	.239	.304	.375	.679