Since 2021, the Los Angeles Dodgers have the most wins by a team, with 437 wins.

Interpreted as:

most regular-season wins by an MLB team since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	437	243	.643	680	23,081	3,594	5,865	1,217	107	982	3,466	2,587	320	5,738	427	89	26,268	10,242	2,306	51	229	123	402	.254	.335	.444	.778
2	Braves	396	282	.584	678	22,994	3,358	5,828	1,178	71	1,038	3,227	2,151	265	5,966	366	101	25,621	10,262	2,287	46	165	80	452	.253	.322	.446	.769
3	Astros	395	283	.583	678	23,122	3,287	5,969	1,167	68	873	3,162	2,194	275	5,068	356	101	25,831	9,891	2,108	49	191	93	531	.258	.327	.428	.755
4	Yankees	386	294	.568	680	22,615	3,186	5,422	960	55	986	3,036	2,598	247	5,926	376	117	25,685	9,450	2,001	47	178	99	550	.240	.322	.418	.740
5	Brewers	382	299	.561	681	22,740	3,127	5,438	1,055	88	782	2,981	2,468	288	6,062	564	131	25,718	9,015	1,925	67	155	90	479	.239	.319	.396	.716
6	Rays	379	301	.557	680	22,884	3,108	5,561	1,162	103	765	2,951	2,190	310	6,108	554	179	25,564	9,224	2,030	29	151	62	392	.243	.316	.403	.719
7	Phillies	372	308	.547	680	23,013	3,204	5,790	1,140	112	850	3,074	2,223	260	5,868	501	109	25,753	9,704	2,102	81	176	100	460	.252	.322	.422	.744
8	Mariners	372	307	.548	679	22,609	2,986	5,232	1,012	57	839	2,863	2,387	408	6,388	442	121	25,604	8,875	1,908	41	159	55	429	.231	.314	.393	.707
9	Giants	367	314	.539	681	22,813	3,036	5,443	1,102	91	808	2,903	2,328	299	6,151	276	76	25,689	9,151	2,001	73	176	95	472	.239	.315	.401	.716
10	Mets	364	317	.535	681	22,679	3,052	5,575	1,062	89	807	2,919	2,161	423	5,569	359	90	25,499	9,236	1,958	83	153	78	480	.246	.321	.407	.728
11	Padres	363	316	.535	679	22,790	3,073	5,661	1,126	74	755	2,939	2,370	248	5,249	444	130	25,696	9,200	1,955	112	176	104	504	.248	.324	.404	.727
12	Blue Jays	362	318	.532	680	23,065	3,151	5,901	1,216	71	828	3,025	2,156	267	5,223	341	112	25,684	9,743	2,115	41	155	63	526	.256	.325	.422	.747
13	Guardians	358	321	.527	679	22,750	2,906	5,563	1,102	102	675	2,754	1,938	299	5,099	551	134	25,255	8,894	1,879	77	191	129	456	.245	.310	.391	.701
14	Cardinals	351	330	.515	681	22,999	3,019	5,719	1,137	77	799	2,894	2,179	302	5,465	404	112	25,738	9,407	2,013	78	180	78	453	.249	.320	.409	.729
15	Red Sox	347	335	.509	682	23,352	3,259	6,001	1,400	88	791	3,108	2,098	281	6,014	390	117	25,947	9,950	2,279	41	175	98	475	.257	.323	.426	.750
16	Orioles	340	339	.501	679	22,913	3,049	5,593	1,149	105	822	2,925	2,017	273	5,842	379	109	25,431	9,418	2,076	53	175	52	409	.244	.311	.411	.722
17	Twins	333	348	.489	681	22,975	3,069	5,610	1,171	86	848	2,923	2,206	345	5,984	261	80	25,740	9,497	2,105	39	175	57	510	.244	.318	.413	.731
18	Cubs	331	350	.486	681	22,843	3,119	5,575	1,075	125	784	2,972	2,257	333	6,058	524	144	25,698	9,252	1,984	96	169	66	459	.244	.319	.405	.724
19	Tigers	328	353	.482	681	22,784	2,761	5,384	1,003	146	659	2,655	1,975	215	6,162	311	98	25,197	8,656	1,808	48	175	41	434	.236	.301	.380	.681
20	Reds	322	359	.473	681	22,738	3,085	5,493	1,107	99	785	2,947	2,177	391	6,090	527	160	25,549	9,153	1,991	86	157	46	461	.242	.317	.403	.719
21	Diamondbacks	316	364	.465	680	22,875	3,176	5,605	1,180	142	736	3,011	2,307	268	5,560	459	107	25,798	9,277	2,058	139	209	70	450	.245	.319	.406	.724
22	Rangers	312	369	.458	681	23,010	3,000	5,573	1,041	80	805	2,867	2,052	222	5,790	437	121	25,481	9,189	1,926	44	153	61	414	.242	.308	.399	.708
23	Angels	298	381	.439	679	22,726	2,831	5,387	999	98	820	2,705	1,980	290	6,169	376	138	25,211	9,042	1,917	77	138	98	455	.237	.305	.398	.703
24	Royals	298	383	.438	681	22,796	2,842	5,594	1,076	149	649	2,727	1,809	238	5,337	551	158	25,157	8,915	1,874	93	221	54	405	.245	.305	.391	.696
25	Marlins	294	385	.433	679	22,835	2,648	5,527	1,028	92	646	2,521	1,809	249	5,955	462	132	25,133	8,677	1,766	88	152	74	508	.242	.303	.380	.683