Between the 1878 and 2022 seasons, the San Francisco Giants had the most wins by a team, with 11,382 wins.

Interpreted as:

most regular-season wins by team 1878 to 2022

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Giants	11,382	9,854	.536	21,399	730,562	99,084	192,492	30,753	6,987	15,187	88,622	67,098	5,529	96,227	16,366	3,096	817,737	282,780	52,927	11,631	2,917	3,980	9,924	.263	.329	.387	.716
2	Dodgers	11,234	9,942	.531	21,315	726,272	95,896	189,793	30,381	6,951	13,573	86,183	67,476	4,984	97,261	17,068	3,493	814,488	274,795	50,905	12,756	2,924	3,664	9,711	.261	.327	.378	.706
3	Cubs	11,083	10,562	.512	21,805	745,607	99,875	195,183	32,934	7,226	14,810	86,531	67,146	5,124	101,919	15,449	2,996	833,665	286,999	54,970	12,989	2,799	3,485	9,758	.262	.326	.385	.711
4	Braves	10,840	10,769	.502	21,762	744,516	96,776	193,288	31,289	6,196	14,472	84,782	66,194	4,928	96,996	13,866	3,011	831,094	280,385	51,957	12,668	2,788	3,620	10,106	.260	.323	.377	.700
5	Reds	10,775	10,601	.504	21,515	733,319	96,508	191,308	31,778	7,488	13,900	85,733	65,487	5,309	98,889	17,717	3,298	819,861	279,762	53,166	12,622	2,956	3,627	9,503	.261	.325	.382	.706
6	Pirates	10,687	10,647	.501	21,474	735,833	95,659	194,027	31,773	8,879	11,900	85,223	63,112	5,394	96,213	15,410	3,198	819,994	279,258	52,552	12,515	3,017	3,668	9,818	.264	.325	.380	.705
7	Yankees	10,602	8,000	.570	18,690	637,277	90,879	169,498	28,086	5,457	16,785	84,385	67,170	4,808	91,668	11,429	2,734	721,999	258,853	50,328	9,571	3,173	2,778	10,397	.266	.339	.406	.745
8	Cardinals	10,351	9,800	.514	20,282	693,838	90,793	184,581	31,217	7,015	12,441	82,922	62,980	5,053	95,144	14,790	3,547	776,852	267,151	50,673	11,938	3,043	3,740	9,885	.266	.330	.385	.715
9	Phillies	10,022	11,187	.473	21,324	729,658	94,533	190,047	32,765	6,618	13,724	84,827	66,513	5,266	102,117	14,629	2,849	816,244	277,220	53,107	11,886	2,921	3,690	9,614	.260	.326	.380	.705
10	Red Sox	9,796	9,098	.518	18,977	649,422	88,609	173,445	32,380	5,543	14,167	82,120	65,665	4,640	92,183	9,329	2,469	733,555	259,412	52,090	10,574	3,254	2,942	11,297	.267	.337	.399	.737
11	Guardians	9,684	9,214	.512	18,989	647,469	85,963	171,676	30,544	5,447	13,558	79,417	61,537	4,675	91,890	11,576	3,294	728,356	253,788	49,549	11,426	3,249	2,469	10,281	.265	.332	.392	.724
12	Tigers	9,512	9,407	.503	19,012	648,474	87,427	171,662	29,028	6,212	14,193	80,444	64,402	4,325	93,367	11,111	2,886	731,211	255,693	49,433	10,988	3,022	2,421	10,489	.265	.334	.394	.728
13	White Sox	9,492	9,390	.503	18,985	642,972	82,763	167,341	27,652	5,527	11,945	76,022	61,170	5,142	88,841	13,411	3,420	724,767	241,882	45,124	12,329	3,154	2,433	10,254	.260	.328	.376	.704
14	Athletics	9,210	9,654	.488	18,951	642,578	83,853	165,718	28,656	5,286	13,714	77,210	63,374	4,586	95,658	11,837	3,143	724,190	246,088	47,656	10,632	3,020	2,244	10,344	.258	.327	.383	.710
15	Twins	9,090	9,800	.481	18,999	648,232	83,458	170,227	29,105	6,280	11,555	76,781	61,158	4,939	91,124	11,837	3,029	727,572	246,557	46,940	10,167	3,076	2,632	10,708	.263	.329	.380	.710
16	Orioles	8,928	9,952	.473	18,990	645,032	81,823	166,546	28,692	4,844	13,961	75,582	62,154	4,345	95,204	10,310	2,723	725,031	246,809	47,497	10,503	2,997	2,544	10,621	.258	.326	.383	.709
17	Angels	4,885	4,927	.498	9,815	333,193	42,510	85,501	14,747	1,764	8,753	39,984	31,201	2,639	59,342	5,820	3,012	373,226	130,035	25,264	3,514	2,679	2,447	7,615	.257	.323	.390	.713
18	Astros	4,831	4,820	.501	9,656	327,589	40,999	83,458	15,295	2,129	7,969	38,558	31,207	2,741	60,139	6,925	3,067	368,149	126,918	25,393	3,996	2,616	3,094	7,116	.255	.322	.387	.710
19	Mets	4,652	4,988	.483	9,648	326,536	39,641	81,680	14,550	1,770	8,104	37,293	31,197	2,633	61,877	5,627	2,692	366,851	124,082	24,424	3,957	2,528	3,109	7,208	.250	.318	.380	.698
20	Rangers	4,650	5,146	.475	9,802	334,690	44,046	86,455	15,359	1,854	9,738	41,594	31,678	2,575	62,094	5,727	2,792	374,630	134,736	26,951	2,945	2,742	2,211	7,570	.258	.325	.403	.727
21	Nationals	4,123	4,387	.484	8,514	288,047	35,660	73,165	14,091	1,738	7,269	33,506	27,235	2,453	54,431	6,150	2,659	323,756	112,539	23,098	3,824	2,197	2,863	6,247	.254	.321	.391	.712
22	Brewers	4,123	4,391	.484	8,518	289,317	37,800	74,244	13,832	1,702	8,323	35,809	27,690	2,586	55,656	5,576	2,647	325,053	116,449	23,857	3,129	2,331	2,118	6,344	.257	.325	.402	.727
23	Royals	4,066	4,441	.478	8,509	291,318	37,262	76,713	14,309	2,202	6,639	35,129	25,037	2,320	49,231	6,753	2,802	323,538	115,343	23,150	2,322	2,541	1,826	6,566	.263	.324	.396	.720
24	Padres	3,952	4,568	.464	8,522	288,145	34,334	71,798	12,664	1,722	6,823	32,268	27,358	2,000	56,757	5,711	2,534	323,312	108,375	21,209	3,650	2,159	2,647	6,203	.249	.316	.376	.693
25	Blue Jays	3,598	3,627	.498	7,228	247,803	33,522	64,585	12,878	1,445	7,872	31,793	22,930	2,260	46,089	4,373	1,904	276,499	103,969	22,195	1,473	2,033	1,361	5,638	.261	.326	.420	.746