Since 2000, the New York Yankees have the most wins by a team, with 2,334 wins.

Interpreted as:

most regular-season wins by team since 2000 in MLB

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,334	1,695	.579	4,031	137,683	20,495	36,008	6,801	501	5,489	19,632	14,939	1,607	29,618	2,469	780	155,954	60,278	12,791	596	1,129	787	3,252	.262	.338	.438	.776
2	Dodgers	2,293	1,741	.568	4,034	137,028	18,748	35,305	6,932	698	4,531	17,887	13,873	1,513	29,401	2,356	862	154,763	57,226	12,161	1,269	1,080	1,079	3,005	.258	.330	.418	.748
3	Cardinals	2,226	1,806	.552	4,032	137,046	18,926	35,915	7,052	597	4,429	18,016	13,370	1,644	28,645	1,938	828	154,588	57,448	12,078	1,396	1,132	1,110	3,139	.262	.332	.419	.752
4	Braves	2,190	1,838	.544	4,029	137,473	18,698	35,647	7,117	610	4,556	17,860	13,464	1,317	30,382	1,999	790	154,623	57,652	12,283	1,354	1,015	1,061	3,104	.259	.329	.419	.748
5	Red Sox	2,187	1,846	.542	4,033	140,092	20,540	37,649	8,376	650	4,751	19,564	14,195	1,480	29,854	2,119	706	157,465	61,578	13,777	493	1,205	968	3,202	.269	.340	.440	.779
6	Giants	2,097	1,934	.520	4,032	137,100	17,636	34,967	7,038	855	3,915	16,786	12,991	1,309	28,942	1,812	765	153,861	55,460	11,808	1,322	1,139	1,240	3,148	.255	.323	.405	.728
7	Guardians	2,086	1,942	.518	4,028	137,281	18,812	35,434	7,364	635	4,367	17,924	13,450	1,576	29,267	2,448	878	154,304	57,169	12,366	827	1,170	772	3,048	.258	.329	.416	.745
8	Astros	2,080	1,951	.516	4,032	137,098	18,564	35,379	7,066	627	4,640	17,712	12,991	1,537	29,326	2,309	921	153,853	57,619	12,333	1,145	1,082	820	3,211	.258	.327	.420	.747
9	Angels	2,076	1,956	.515	4,032	137,553	18,551	35,700	6,816	658	4,372	17,661	12,245	1,456	28,148	2,693	1,066	153,195	56,948	11,846	820	1,121	880	3,096	.260	.324	.414	.738
10	Phillies	2,069	1,963	.513	4,032	137,745	18,510	35,053	7,041	798	4,488	17,654	13,662	1,513	30,888	2,603	695	155,117	57,154	12,327	1,202	995	1,133	2,790	.254	.326	.415	.741
11	Athletics	2,066	1,968	.512	4,034	137,204	18,319	34,227	7,051	583	4,433	17,459	13,961	1,441	29,624	1,922	623	154,226	55,743	12,067	532	1,088	611	3,187	.249	.323	.406	.729
12	Twins	2,024	2,010	.502	4,034	138,290	18,631	35,944	7,276	769	4,170	17,679	12,879	1,407	29,377	2,102	867	154,382	57,268	12,215	692	1,114	754	3,141	.260	.327	.414	.741
13	Mets	2,024	2,007	.502	4,031	136,610	17,670	34,466	6,814	658	4,258	16,866	13,189	1,626	29,654	2,411	814	153,725	55,370	11,730	1,286	1,014	1,053	3,000	.252	.323	.405	.729
14	Blue Jays	2,024	2,008	.502	4,032	138,008	19,052	35,621	7,466	577	4,918	18,198	12,954	1,450	28,986	1,949	725	154,060	58,995	12,961	564	1,084	596	3,222	.258	.326	.427	.753
15	Cubs	2,019	2,012	.501	4,032	137,104	18,195	34,788	7,019	722	4,553	17,332	13,198	1,577	31,490	2,061	843	154,189	56,910	12,294	1,326	984	953	2,966	.254	.324	.415	.739
16	Mariners	2,019	2,014	.501	4,033	137,519	17,720	34,778	6,562	579	4,214	16,869	12,720	1,504	30,325	2,577	932	153,571	55,140	11,355	778	1,050	774	2,901	.253	.321	.401	.722
17	Brewers	2,007	2,025	.498	4,033	136,252	17,977	34,188	6,884	675	4,638	17,172	13,299	1,670	32,677	2,724	920	153,429	56,336	12,197	1,237	971	926	3,029	.251	.323	.413	.736
18	Rays	2,006	2,026	.498	4,032	136,964	18,004	34,629	6,946	784	4,293	17,143	13,066	1,590	31,579	3,068	1,118	153,360	56,022	12,023	662	1,078	644	2,768	.253	.323	.409	.732
19	Rangers	1,979	2,056	.490	4,035	138,541	19,591	36,112	7,147	663	4,977	18,660	12,550	1,473	30,114	2,465	880	154,418	59,516	12,787	730	1,124	689	2,895	.261	.326	.430	.756
20	Diamondbacks	1,965	2,068	.487	4,033	137,511	18,376	34,961	7,243	983	4,296	17,528	13,402	1,328	30,634	2,316	833	154,600	57,058	12,522	1,226	1,133	1,009	2,887	.254	.324	.415	.739
21	White Sox	1,939	2,094	.481	4,033	137,205	18,139	35,216	6,665	565	4,657	17,379	11,722	1,525	29,632	2,245	991	152,355	56,982	11,887	879	1,024	550	3,122	.257	.320	.415	.735
22	Padres	1,933	2,100	.479	4,033	136,083	16,997	33,661	6,526	728	3,868	16,158	13,346	1,250	31,127	2,501	888	152,924	53,247	11,122	1,194	1,051	860	2,912	.247	.318	.391	.709
23	Nationals	1,913	2,117	.475	4,030	136,182	17,525	34,713	7,063	664	4,025	16,668	12,901	1,455	29,677	2,496	973	153,039	55,179	11,752	1,471	1,030	1,038	3,075	.255	.324	.405	.729
24	Reds	1,905	2,128	.472	4,035	136,736	17,987	34,394	6,818	607	4,619	17,173	13,268	1,707	31,881	2,551	965	154,088	56,283	12,044	1,394	983	934	2,860	.252	.323	.412	.735
25	Tigers	1,894	2,134	.470	4,028	138,076	18,009	35,958	6,897	957	4,157	17,231	11,845	1,244	30,232	1,825	825	153,004	57,240	12,011	739	1,100	676	3,110	.260	.322	.415	.737