Warren Spahn had the most wins when allowing 1+ run, with 297 wins.

Interpreted as:

most regular-season wins by a player in 1 or more run games

	NAME	W	R	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Warren Spahn W. Spahn	297	2,018	245	.548	637	602	3.52	2,231	319	0	2	4609.2	4,502	1,801	434	1,310	41	25	55	19,273	73	4.36	2.56	1.70	0.85	11.6	6.8	1.26	.267	3.94	8.79
2	Grover Alexander G. Alexander	271	1,851	208	.566	554	509	2.92	1,770	347	0	6	4277.0	4,370		165	835	63	32		17,683	35	3.72	1.76	2.12	0.35	10.0	4.7	1.22	.283	3.90	9.20
3	Walter Johnson W. Johnson	271	1,902	279	.493	612	547	2.14	2,701	421	0	11	4687.0	4,313		97	1,175	180	59			136	5.19	2.26	2.30	0.19		6.1	1.17	.280	3.65	8.28
4	Greg Maddux G. Maddux	265	1,981	227	.539	635	632	3.76	2,811	74	0	0	4199.2	4,271	1,756	353	892	120	3	162	17,510	66	6.02	1.91	3.15	0.76	16.1	5.1	1.23	.294	4.25	9.15
5	Roger Clemens R. Clemens	264	1,885	184	.589	602	601	3.76	3,824	72	0	0	4083.0	3,782	1,707	363	1,386	144	0	59	17,193	130	8.43	3.06	2.76	0.80	22.2	8.1	1.27	.298	4.16	8.34
6	Steve Carlton S. Carlton	262	2,130	244	.518	647	631	3.69	3,619	199	0	1	4541.1	4,340	1,864	414	1,673	46	4	142	19,245	169	7.17	3.32	2.16	0.82	18.8	8.7	1.32	.291	4.22	8.60
7	Christy Mathewson C. Mathewson	259	1,585	185	.583	490	458	1.20	2,000	355	0	6	3869.2	3,714		88	717	50	25			102	4.65	1.67	2.79	0.20		4.6	1.15	.285	3.69	8.64
8	Lefty Grove L. Grove	249	1,596	141	.638	496	418	3.48	1,941	263	0	8	3466.0	3,603	1,341	162	1,085	37	49		14,878	44	5.04	2.82	1.79	0.42	13.0	7.3	1.35	.295	4.14	9.36
9	Don Sutton D. Sutton	248	2,104	256	.492	675	670	3.80	3,066	120	0	0	4528.1	4,291	1,914	472	1,195	76	3	86	18,884	104	6.09	2.38	2.57	0.94	16.2	6.3	1.21	.271	4.18	8.53
10	Gaylord Perry G. Perry	248	2,128	265	.483	665	626	3.54	3,080	250	0	0	4688.1	4,607	1,846	399	1,253	96	13	157	19,568	150	5.91	2.41	2.46	0.77	15.7	6.4	1.25	.285	4.09	8.84
11	Tom Glavine T. Glavine	246	1,900	203	.548	613	613	4.00	2,314	31	0	0	3905.1	4,016	1,734	356	1,390	62	0	142	16,737	62	5.33	3.20	1.66	0.82	13.8	8.3	1.38	.290	4.38	9.26
12	Phil Niekro P. Niekro	245	2,337	274	.472	707	650	3.85	2,887	200	0	2	4702.0	4,699	2,012	482	1,624	117	22	82	20,099	208	5.53	3.11	1.78	0.92	14.4	8.1	1.34	.281	4.47	8.99
13	Early Wynn E. Wynn	240	2,037	244	.496	589	557	4.04	2,039	240	0	2	3997.2	4,025	1,793	339	1,604	57	27	34	17,329	45	4.59	3.61	1.27	0.76	11.8	9.3	1.41	.277	4.59	9.06
14	Eddie Plank E. Plank	239	1,566	194	.552	502	455	1.65	1,825	341	0	8	3703.2	3,544		42	893	169	35			82	4.43	2.17	2.04	0.10		6.3	1.20	.310	3.81	8.61
15	Tom Seaver T. Seaver	234	1,674	205	.533	564	561	3.38	3,057	170	0	0	4055.1	3,643	1,521	380	1,232	70	2	107	16,762	117	6.78	2.73	2.48	0.84	18.2	7.3	1.20	.271	3.72	8.08
16	Robin Roberts R. Roberts	234	1,962	245	.489	587	562	3.79	2,115	260	0	2	4215.0	4,314	1,773	505	837	50	13	69	17,514	31	4.52	1.79	2.53	1.08	12.1	4.8	1.22	.272	4.19	9.21
17	Jim Kaat J. Kaat	230	2,038	237	.493	682	577	3.97	2,165	149	0	1	3936.2	4,242	1,738	395	981	113	31	100	16,839	115	4.95	2.24	2.21	0.90	12.9	5.8	1.33	.292	4.66	9.70
18	Randy Johnson R. Johnson	228	1,703	166	.579	526	520	3.93	4,001	63	0	0	3461.0	3,037	1,513	411	1,349	180	1	35	14,642	105	10.40	3.51	2.97	1.07	27.3	9.2	1.27	.302	4.43	7.90
19	Fergie Jenkins F. Jenkins	227	1,853	226	.501	568	535	3.81	2,781	218	0	0	3947.0	3,857	1,669	484	900	78	14	107	16,405	59	6.34	2.05	3.09	1.10	17.0	5.5	1.21	.277	4.23	8.79
20	Ted Lyons T. Lyons	227	2,055	230	.497	517	457	3.98	999	329	0	4	3833.1	4,309	1,696	221	1,064	30	45		16,616	53	2.35	2.50	0.94	0.52	6.0	6.4	1.40	.286	4.82	10.12
21	Burleigh Grimes B. Grimes	225	2,048	212	.515	530	460	3.93	1,366	279	0	3	3764.2	4,204	1,644	149	1,200	93	51		16,465	91	3.27	2.87	1.14	0.36	8.3	7.3	1.44	.297	4.90	10.05
22	Nolan Ryan N. Ryan	222	2,178	292	.432	672	657	3.85	4,638	161	0	1	4462.2	3,587	1,911	321	2,412	142	5	74	19,166	256	9.35	4.86	1.92	0.65	24.2	12.6	1.34	.280	4.39	7.23
23	Red Ruffing R. Ruffing	221	2,117	225	.496	535	488	4.29	1,738	290	0	4	3845.2	4,043	1,835	254	1,424	54	33		16,734	44	4.07	3.33	1.22	0.59	10.4	8.5	1.42	.286	4.95	9.46
24	Mike Mussina M. Mussina	219	1,559	153	.589	477	476	4.22	2,402	34	0	0	3112.1	3,238	1,458	376	710	55	0	28	12,988	66	6.95	2.05	3.38	1.09	18.5	5.5	1.27	.303	4.51	9.36
25	Tommy John T. John	218	2,017	231	.486	647	623	3.91	1,895	116	0	0	4024.2	4,384	1,749	302	1,129	87	4	94	17,194	171	4.24	2.52	1.68	0.68	11.0	6.6	1.37	.296	4.51	9.80