Chris Sale has won the most career games by an active left-hander, with 145 wins.

Interpreted as:

most regular-season wins left handed pitcher current

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Chris Sale C. Sale	145	88	.622	393	312	3.01	2,579	16	3	12	2084.0	1,692	697	750	213	487	130	25	15	8,389	48	11.14	2.10	5.30	0.92	30.7	5.8	1.05	.297	3.24	70	2.87	68	7.31	303.3
2	Eduardo Rodriguez E. Rodriguez	94	66	.588	241	235	4.19	1,297	0	0	0	1304.2	1,280	607	641	167	455	32	1	9	5,579	17	8.95	3.14	2.85	1.15	23.2	8.2	1.33	.307	4.42	95	3.96	95	8.83	34.8
3	Carlos Rodón C. Rodón	93	72	.564	231	226	3.73	1,409	3	1	0	1282.0	1,085	532	574	159	477	65	1	5	5,378	65	9.89	3.35	2.95	1.12	26.2	8.9	1.22	.283	4.03	90	3.83	90	7.62	58.2
4	Max Fried M. Fried	92	41	.692	200	183	3.03	1,052	6	4	0	1079.2	947	364	405	90	297	45	10	6	4,415	47	8.77	2.48	3.54	0.75	23.8	6.7	1.15	.292	3.38	71	3.24	78	7.89	112
5	Robbie Ray R. Ray	88	81	.521	265	261	3.94	1,734	2	1	0	1441.0	1,250	631	674	216	608	51	1	19	6,097	60	10.83	3.80	2.85	1.35	28.4	10.0	1.29	.296	4.21	94	4.06	99	7.81	5.1
6	Blake Snell B. Snell	81	62	.566	222	222	3.15	1,440	1	1	0	1158.0	891	405	440	111	521	11	0	6	4,791	86	11.19	4.05	2.76	0.86	30.1	10.9	1.22	.288	3.42	77	3.31	79	6.92	111.7
7	Sean Manaea S. Manaea	79	66	.545	243	210	4.08	1,184	3	3	0	1245.0	1,150	565	611	171	347	61	5	4	5,196	36	8.56	2.51	3.41	1.24	22.8	6.7	1.20	.285	4.42	100	4.02	98	8.31	14.6
8	Kyle Freeland K. Freeland	64	90	.416	236	231	4.54	944	0	0	0	1260.1	1,394	636	690	180	392	47	0	12	5,466	17	6.74	2.80	2.41	1.29	17.3	7.2	1.42	.311	4.93	94	4.57	103	9.95	-17.5
9	Matthew Boyd M. Boyd	60	77	.438	213	199	4.57	1,045	2	1	0	1088.0	1,053	553	589	176	336	53	2	7	4,614	32	8.64	2.78	3.11	1.46	22.6	7.3	1.28	.292	4.87	106	4.42	103	8.71	-14.8
10	Aroldis Chapman A. Chapman	60	47	.561	863	0	2.52	1,331	0	0	367	821.1	475	230	255	54	408	33	563	7	3,341	87	14.58	4.47	3.26	0.59	39.8	12.2	1.08	.278	2.79	61	2.36	57	5.20	161.8
11	Tarik Skubal T. Skubal	54	37	.593	137	134	3.08	889	1	1	0	766.2	614	262	287	90	172	26	1	0	3,056	11	10.44	2.02	5.17	1.06	29.1	5.6	1.03	.279	3.37	75	3.14	76	7.21	84
12	Yusei Kikuchi Y. Kikuchi	48	58	.453	199	187	4.46	1,011	1	1	1	988.0	986	490	535	165	356	29	4	3	4,243	36	9.21	3.24	2.84	1.50	23.8	8.4	1.36	.306	4.87	108	4.47	105	8.98	-26.1
13	Eric Lauer E. Lauer	45	39	.536	148	127	4.13	669	0	0	0	701.1	675	322	354	111	256	19	3	8	3,003	14	8.59	3.29	2.61	1.42	22.3	8.5	1.33	.290	4.54	100	4.48	107	8.66	-22.1
14	Brent Suter B. Suter	42	24	.636	348	47	3.57	496	0	0	3	597.1	577	237	275	76	153	20	83	8	2,488	9	7.47	2.31	3.24	1.15	19.9	6.1	1.22	.287	4.14	83	4.02	94	8.69	17.6
15	Jesús Luzardo J. Luzardo	41	41	.500	137	121	4.19	775	0	0	2	695.2	628	324	343	87	237	21	4	3	2,904	30	10.03	3.07	3.27	1.13	26.7	8.2	1.24	.303	4.44	99	3.68	88	8.12	39.4
16	David Peterson D. Peterson	37	30	.552	131	115	4.12	614	2	1	0	622.2	593	285	306	62	262	35	0	2	2,671	23	8.87	3.79	2.34	0.90	23.0	9.8	1.37	.313	4.42	102	3.91	95	8.57	14.3
17	Jeffrey Springs J. Springs	34	23	.596	177	67	3.64	497	0	0	2	484.2	440	196	221	70	158	7	28	3	2,033	9	9.23	2.93	3.15	1.30	24.4	7.8	1.23	.284	4.10	88	3.99	97	8.17	6.7
18	Josh Hader J. Hader	34	31	.523	468	0	2.64	829	0	0	226	512.1	282	150	164	65	198	24	321	6	2,019	19	14.56	3.48	4.19	1.14	41.1	9.8	0.94	.240	2.88	64	2.88	69	4.95	75.7
19	Matt Strahm M. Strahm	34	38	.472	395	35	3.36	582	0	0	15	517.1	421	193	209	62	150	35	60	12	2,130	18	10.13	2.61	3.88	1.08	27.3	7.0	1.10	.276	3.64	80	3.56	83	7.32	39.5
20	Shane McClanahan S. McClanahan	33	16	.673	74	74	3.02	456	0	0	0	404.2	331	136	143	48	116	5	0	1	1,627	19	10.14	2.58	3.93	1.07	28.0	7.1	1.10	.282	3.18	77	3.35	84	7.36	29.1
21	Justin Steele J. Steele	32	22	.593	102	91	3.30	517	1	0	0	506.2	460	186	219	51	155	20	2	2	2,123	14	9.18	2.75	3.34	0.91	24.4	7.3	1.21	.296	3.89	80	3.48	85	8.17	35.4
22	Tanner Scott T. Scott	32	28	.533	444	0	3.72	546	0	0	78	425.2	352	176	200	39	220	25	167	14	1,836	29	11.54	4.65	2.48	0.82	29.7	12.0	1.34	.311	4.23	87	3.52	82	7.44	36.7
23	JP Sears	31	39	.443	108	102	4.53	466	0	0	0	558.2	547	281	293	100	161	38	1	3	2,364	3	7.51	2.59	2.89	1.61	19.7	6.8	1.27	.280	4.72	114	4.90	121	8.81	-54.2
24	Cristopher Sánchez C. Sánchez	30	21	.588	104	85	3.24	509	3	1	1	535.2	495	193	211	45	128	13	4	1	2,193	16	8.55	2.15	3.98	0.76	23.2	5.8	1.16	.300	3.55	77	3.14	74	8.32	63.7
25	Andrew Abbott A. Abbott	28	22	.560	75	75	3.42	383	1	1	0	413.2	375	157	167	60	139	6	0	1	1,729	10	8.33	3.02	2.76	1.31	22.2	8.0	1.24	.276	3.63	76	4.26	96	8.16	8.1