The Los Angeles Dodgers had the highest run differential by an NL team in 2021, with a differential of 269 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	269	2021	162	.654	106	56	5,445	830	1,330	247	24	237	799	613	104	1,408	65	17	6,239	2,336	508	32	45	36	96	.244	.330	.429	.759
2	Giants	210	2021	162	.660	107	55	5,462	804	1,360	271	25	241	768	602	64	1,461	66	14	6,194	2,404	537	36	30	45	117	.249	.329	.440	.769
3	Braves	134	2021	161	.547	88	73	5,363	790	1,307	269	20	239	762	549	67	1,453	59	19	6,054	2,333	528	32	43	36	81	.244	.319	.435	.754
4	Brewers	115	2021	162	.586	95	67	5,362	738	1,251	255	18	194	700	586	88	1,465	82	21	6,096	2,124	467	25	35	26	102	.233	.317	.396	.713
5	Cardinals	34	2021	162	.556	90	72	5,351	706	1,303	261	22	198	678	478	86	1,341	89	22	5,999	2,202	481	40	44	32	99	.244	.313	.412	.725
6	Reds	26	2021	162	.512	83	79	5,423	786	1,352	295	13	222	756	553	105	1,425	36	24	6,161	2,339	530	35	45	22	129	.249	.328	.431	.759
7	Padres	21	2021	162	.488	79	83	5,384	729	1,305	273	21	180	695	586	61	1,324	110	39	6,113	2,160	474	36	46	42	121	.242	.321	.401	.722
8	Phillies	-11	2021	162	.506	82	80	5,366	734	1,288	262	24	198	700	564	67	1,402	77	19	6,087	2,192	484	47	43	37	103	.240	.318	.408	.726
9	Mets	-32	2021	162	.475	77	85	5,210	636	1,243	228	18	176	604	495	94	1,392	54	26	5,856	2,035	422	34	23	25	123	.239	.315	.391	.705
10	Rockies	-57	2021	161	.460	74	87	5,374	739	1,338	275	34	182	709	491	58	1,356	76	23	6,007	2,227	491	48	36	24	98	.249	.317	.414	.731
11	Marlins	-78	2021	162	.414	67	95	5,348	623	1,244	226	23	158	594	450	65	1,553	106	29	5,923	1,990	407	30	30	25	95	.233	.298	.372	.671
12	Nationals	-96	2021	162	.401	65	97	5,385	724	1,388	272	20	182	686	573	84	1,303	56	26	6,111	2,246	474	38	31	43	158	.258	.337	.417	.754
13	Cubs	-134	2021	162	.438	71	91	5,306	705	1,255	225	26	210	672	502	92	1,596	86	37	5,970	2,162	461	40	30	17	133	.237	.312	.407	.719
14	Diamondbacks	-214	2021	162	.321	52	110	5,489	679	1,297	308	31	144	644	537	54	1,465	43	16	6,140	2,099	483	32	28	24	99	.236	.309	.382	.692
15	Pirates	-224	2021	162	.377	61	101	5,336	609	1,261	240	35	124	570	529	49	1,328	60	30	5,982	1,943	399	31	37	24	102	.236	.309	.364	.673