The Los Angeles Dodgers had the highest run differential by an NL team in 2022, with a differential of 334 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	334	2022	162	.685	111	51	5,526	847	1,418	325	31	212	812	607	56	1,374	98	18	6,245	2,441	568	3	53	22	85	.257	.333	.442	.775
2	Braves	180	2022	162	.623	101	61	5,509	789	1,394	298	11	243	753	470	66	1,498	87	31	6,082	2,443	552	1	36	13	103	.253	.317	.443	.761
3	Mets	166	2022	162	.623	101	61	5,489	772	1,422	272	27	171	735	510	112	1,217	62	22	6,175	2,261	470	20	44	25	122	.259	.332	.412	.744
4	Cardinals	135	2022	162	.574	93	69	5,496	772	1,386	290	21	197	739	537	80	1,226	95	25	6,163	2,309	508	5	45	11	112	.252	.325	.420	.745
5	Phillies	62	2022	162	.537	87	75	5,496	747	1,392	255	29	205	719	478	52	1,363	105	28	6,076	2,320	489	6	44	15	116	.253	.317	.422	.739
6	Padres	45	2022	162	.549	89	73	5,468	705	1,317	275	18	153	682	574	65	1,327	49	22	6,170	2,087	446	17	46	24	95	.241	.318	.382	.700
7	Brewers	37	2022	162	.531	86	76	5,417	725	1,271	251	17	219	703	577	80	1,464	96	30	6,122	2,213	487	11	37	25	117	.235	.315	.409	.724
8	Giants	19	2022	162	.500	81	81	5,392	716	1,261	255	18	183	683	571	95	1,462	64	16	6,117	2,101	456	6	53	14	109	.234	.315	.390	.705
9	Diamondbacks	-38	2022	162	.457	74	88	5,351	702	1,232	262	24	173	658	531	60	1,341	104	29	6,023	2,061	459	31	50	14	97	.230	.304	.385	.689
10	Cubs	-74	2022	162	.457	74	88	5,425	657	1,293	265	31	159	620	507	84	1,448	111	37	6,071	2,097	455	19	36	16	130	.238	.311	.387	.698
11	Marlins	-90	2022	162	.426	69	93	5,395	586	1,241	248	20	144	554	436	70	1,429	122	29	5,941	1,961	412	4	36	6	120	.230	.294	.363	.658
12	Reds	-167	2022	162	.383	62	100	5,380	648	1,264	235	18	156	618	452	92	1,430	58	33	5,969	2,003	409	12	33	6	127	.235	.304	.372	.676
13	Rockies	-175	2022	162	.420	68	94	5,540	698	1,408	280	34	149	669	453	61	1,330	45	20	6,104	2,203	463	10	40	10	139	.254	.315	.398	.713
14	Pirates	-226	2022	162	.383	62	100	5,331	591	1,186	221	29	158	555	476	54	1,497	89	32	5,912	1,939	408	19	32	14	96	.222	.291	.364	.655
15	Nationals	-252	2022	162	.340	55	107	5,434	603	1,351	252	20	136	579	442	60	1,221	75	31	5,993	2,051	408	20	37	12	141	.249	.310	.377	.688