Nolan Ryan struck out his most hitters in a game 4 times, with 19 strikeouts.

	NAME	SO	DATE	TM		OPP	DEC	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Nolan Ryan N. Ryan	19	6/8/1977	CAL	vs	TOR		1	0.00	0	0	0	10.0	6	0	1	0	5	0	0	1	41	2
2	Nolan Ryan N. Ryan	19	8/20/1974	CAL	vs	DET	L	1	0.82	1	0	0	11.0	4	1	1	0	5	0	0	0	41	0
3	Nolan Ryan N. Ryan	19	8/12/1974	CAL	vs	BOS	W	1	2.00	1	0	0	9.0	7	2	2	0	2	0	0	0	36	1
4	Nolan Ryan N. Ryan	19	6/14/1974	CAL	vs	BOS		1	2.08	0	0	0	13.0	8	3	3	1	10	0	0	0	58	0
5	Nolan Ryan N. Ryan	18	9/10/1976	CAL	@	CWS	W	1	2.00	1	0	0	9.0	3	2	2	0	9	0	0	0	41	0
6	Nolan Ryan N. Ryan	17	8/18/1976	CAL	@	DET	W	1	2.70	0	0	0	10.0	9	3	4	1	5	0	0	0	43	1
7	Nolan Ryan N. Ryan	17	7/15/1973	CAL	@	DET	W	1	0.00	1	1	0	9.0	0	0	0	0	4	0	0	0	31	0
8	Nolan Ryan N. Ryan	17	9/30/1972	CAL	vs	MIN	W	1	2.00	1	0	0	9.0	5	2	2	0	3	0	0	0	35	0
9	Nolan Ryan N. Ryan	16	5/1/1991	TEX	vs	TOR	W	1	0.00	1	1	0	9.0	0	0	0	0	2	0	0	0	29	0
10	Nolan Ryan N. Ryan	16	4/26/1990	TEX	vs	CWS	W	1	0.00	1	1	0	9.0	1	0	0	0	2	0	0	0	29	1
11	Nolan Ryan N. Ryan	16	9/9/1987	HOU	vs	SFG	W	1	2.25	0	0	0	8.0	6	2	2	0	2	1	0	0	33	0
12	Nolan Ryan N. Ryan	16	6/9/1979	CAL	vs	DET	W	1	1.00	1	0	0	9.0	4	1	1	0	2	1	0	0	33	0
13	Nolan Ryan N. Ryan	16	9/27/1973	CAL	vs	MIN	W	1	2.45	1	0	0	11.0	10	3	4	0	7	0	0	0	49	1
14	Nolan Ryan N. Ryan	16	7/9/1972	CAL	vs	BOS	W	1	0.00	1	1	0	9.0	1	0	0	0	1	0	0	0	29	0
15	Nolan Ryan N. Ryan	16	7/1/1972	CAL	vs	OAK	W	1	3.00	1	0	0	9.0	5	3	3	0	3	2	0	0	35	1
16	Nolan Ryan N. Ryan	16	5/29/1971	NYM	@	SDP	W	1	0.00	1	0	0	9.0	4	0	1	0	4	0	0	0	34	1
17	Nolan Ryan N. Ryan	15	8/17/1990	TEX	vs	CWS		1	0.00	0	0	0	10.0	3	0	0	0	0	1	0	0	34	0
18	Nolan Ryan N. Ryan	15	4/12/1989	TEX	@	MIL	W	1	0.00	0	0	0	8.0	1	0	0	0	2	0	0	0	27	0
19	Nolan Ryan N. Ryan	15	4/24/1978	CAL	vs	SEA		1	4.00	0	0	0	9.0	7	4	4	1	5	0	0	0	39	2
20	Nolan Ryan N. Ryan	15	5/6/1977	CAL	@	BOS	W	1	3.12	0	0	0	8.2	6	3	4	0	7	1	0	0	40	1
21	Nolan Ryan N. Ryan	15	6/19/1976	CAL	vs	BOS	W	1	2.00	1	0	0	9.0	6	2	3	1	4	0	0	0	36	0
22	Nolan Ryan N. Ryan	15	9/28/1974	CAL	vs	MIN	W	1	0.00	1	1	0	9.0	0	0	0	0	8	0	0	0	35	0
23	Nolan Ryan N. Ryan	15	9/11/1974	CAL	vs	KCR	W	1	1.80	1	0	0	10.0	4	2	2	0	4	0	0	0	38	0
24	Nolan Ryan N. Ryan	15	4/30/1974	CAL	@	BOS	W	1	6.00	1	0	0	9.0	6	6	6	2	7	2	0	0	40	0
25	Nolan Ryan N. Ryan	15	9/12/1972	CAL	vs	TEX	L	1	2.00	1	0	0	9.0	6	2	3	0	3	1	0	0	35	2

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Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Nolan Ryan struck out his most hitters in a game 4 times, with 19 strikeouts.

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