Babe Ruth has the highest career OPS when making 5,000+ plate appearances, with an OPS of 1.164.

	NAME	OPS	PA	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	WRC	WRAA	WOBA	WRC+	BRAA
1	Babe Ruth B. Ruth	1.164	10,617	2,503	8,399	2,174	2,873	506	136	714	2,214	2,062	43	1,330	123		5,793	1,356	113				.342	.474	.690	2727	1,436.8	.513	197	1,369.6
2	Ted Williams T. Williams	1.116	9,791	2,292	7,706	1,798	2,654	525	71	521	1,839	2,021	39	709	24	4	4,884	1,117	5	20	86	197	.344	.482	.634	2349	1,219.7	.493	188	1,067
3	Lou Gehrig L. Gehrig	1.080	9,660	2,164	8,001	1,888	2,721	534	163	493	1,995	1,508	45	790	102		5,060	1,190	106			2	.340	.447	.632	2265	1,046.8	.477	173	980
4	Barry Bonds B. Bonds	1.051	12,606	2,986	9,847	2,227	2,935	601	77	762	1,996	2,558	106	1,539	514	141	5,976	1,440	4	91	688	165	.298	.444	.607	2663	1,143.3	.435	172	1,142
5	Jimmie Foxx J. Foxx	1.038	9,670	2,317	8,134	1,751	2,646	458	125	534	1,922	1,452	13	1,311	87		4,956	1,117	71			69	.325	.428	.609	2135	934.1	.460	158	780.8
6	Hank Greenberg H. Greenberg	1.017	6,096	1,394	5,193	1,046	1,628	379	71	331	1,274	852	16	844	58		3,142	781	35			66	.313	.412	.605	1287	556.1	.453	154	446.7
7	Rogers Hornsby R. Hornsby	1.010	9,475	2,259	8,173	1,579	2,930	541	169	301	1,584	1,038	48	679	135		4,712	1,011	216				.358	.434	.577	2018	899	.459	173	863.2
8	Manny Ramirez M. Ramirez	.996	9,774	2,302	8,244	1,544	2,574	547	20	555	1,831	1,329	109	1,813	38	33	4,826	1,122	2	90	216	243	.312	.411	.585	1931	719.5	.418	153	658.7
9	Mike Trout M. Trout	.984	6,866	1,570	5,697	1,148	1,690	313	55	390	982	1,009	102	1,546	214	38	3,283	758	0	58	125	71	.297	.408	.576	1341	544.4	.413	167	546.8
10	Mark McGwire M. McGwire	.982	7,660	1,874	6,187	1,167	1,626	252	6	583	1,414	1,317	75	1,596	12	8	3,639	841	3	78	150	147	.263	.394	.588	1480	564.9	.415	157	558.2
11	Mickey Mantle M. Mantle	.977	9,909	2,401	8,102	1,676	2,415	344	72	536	1,509	1,733	13	1,710	153	38	4,511	952	14	47	126	113	.298	.421	.557	1941	840	.428	170	821.8
12	Joe DiMaggio J. DiMaggio	.977	7,671	1,736	6,821	1,390	2,214	389	131	361	1,537	790	46	369	30	0	3,948	881	14			130	.325	.398	.579	1517	604.1	.439	152	528.8
13	Stan Musial S. Musial	.976	12,712	3,026	10,972	1,949	3,630	725	177	475	1,951	1,599	53	696	78	31	6,134	1,377	35	53	127	243	.331	.417	.559	2474	1,032.5	.435	158	896.7
14	Frank Thomas F. Thomas	.974	10,074	2,322	8,199	1,494	2,468	495	12	521	1,704	1,667	87	1,397	32	23	4,550	1,028	0	121	168	226	.301	.419	.555	1954	721.1	.416	154	692
15	Larry Walker L. Walker	.965	8,030	1,988	6,907	1,355	2,160	471	62	383	1,311	913	138	1,231	230	76	3,904	916	7	65	117	153	.313	.400	.565	1532	556.6	.412	140	406.2
16	Johnny Mize J. Mize	.959	7,371	1,884	6,443	1,118	2,011	367	83	359	1,337	856	52	524	28	0	3,621	809	20			76	.312	.397	.562	1421	546.3	.433	157	508.1
17	Jim Thome J. Thome	.956	10,313	2,543	8,422	1,583	2,328	451	26	612	1,699	1,747	69	2,548	19	20	4,667	1,089	1	74	173	165	.276	.402	.554	1925	653.9	.406	145	589.5
18	Todd Helton T. Helton	.953	9,450	2,247	7,962	1,401	2,519	592	37	369	1,406	1,335	57	1,175	37	29	4,292	998	3	93	185	186	.316	.414	.539	1765	612.5	.405	132	389.5
19	Jeff Bagwell J. Bagwell	.948	9,431	2,150	7,797	1,517	2,314	488	32	449	1,529	1,401	128	1,558	202	78	4,213	969	3	102	155	221	.297	.408	.540	1755	596.6	.405	149	588.3
20	Mel Ott M. Ott	.947	11,337	2,730	9,456	1,859	2,876	488	72	511	1,860	1,708	64	896	89		5,041	1,071	109			38	.304	.414	.533	2204	826.4	.430	156	794.2
21	Ralph Kiner R. Kiner	.946	6,256	1,472	5,205	971	1,451	216	39	369	1,015	1,011	24	749	22	2	2,852	624	9	7	1	126	.279	.398	.548	1167	442.7	.427	147	364.2
22	Ty Cobb T. Cobb	.945	13,068	3,034	11,434	2,244	4,189	724	295	117	1,933	1,249	94	681	897		5,854	1,136	291				.366	.433	.512	2534	1,093.6	.445	165	975.1
23	Lance Berkman L. Berkman	.943	7,813	1,879	6,491	1,146	1,905	422	30	366	1,234	1,201	66	1,300	86	48	3,485	818	1	54	160	147	.293	.406	.537	1424	477.5	.400	144	432.3
24	Dan Brouthers D. Brouthers	.942	7,676	1,673	6,711	1,523	2,296	460	205	106	994	840	105	83	256		3,484	771	20				.342	.423	.519	1874	728.6	.436	155	655.7
25	Willie Mays W. Mays	.941	12,493	2,992	10,881	2,062	3,283	523	140	660	1,903	1,464	44	1,526	338	103	6,066	1,323	13	91	192	251	.302	.384	.557	2266	894.8	.409	154	802.7