6 players are tied for the most strikeouts for the Padres in a game, with 5 strikeouts. The first three are Chase Headley on June 7, 2009, Tadahito Iguchi on May 25, 2008 and Mike Cameron on September 12, 2007.

Interpreted as:

padres player most strikeouts in a regular-season game

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Chase Headley C. Headley	5	6/7/2009	SDP	vs	ARI	8	1	1	0	0	0	1	0	0	0	0	8	1	0	0	0	0	0
2	Tadahito Iguchi T. Iguchi	5	5/25/2008	SDP	vs	CIN	9	1	1	1	0	0	1	0	0	0	0	9	2	1	0	0	0	0
3	Mike Cameron M. Cameron	5	9/12/2007	SDP	@	LAD	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
4	Clay Hensley C. Hensley	5	5/14/2006	SDP	@	CHC	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
5	Andujar Cedeno A. Cedeno	5	7/6/1995	SDP	@	HOU	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Jack Clark J. Clark	5	6/11/1989	SDP	@	SFG	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
7	Mason McCoy M. McCoy	4	8/30/2024	SDP	@	TBR	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	1
8	Kyle Higashioka K. Higashioka	4	8/21/2024	SDP	vs	MIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
9	Jackson Merrill J. Merrill	4	7/19/2024	SDP	@	CLE	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
10	Fernando Tatis Jr. F. Tatis Jr.	4	6/16/2024	SDP	@	NYM	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
11	Kyle Higashioka K. Higashioka	4	3/30/2024	SDP	vs	SFG	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
12	Eguy Rosario E. Rosario	4	9/19/2023	SDP	vs	COL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
13	Juan Soto J. Soto	4	8/8/2023	SDP	@	SEA	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
14	Xander Bogaerts X. Bogaerts	4	5/24/2023	SDP	@	WSH	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
15	Trent Grisham T. Grisham	4	5/17/2023	SDP	vs	KCR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
16	Manny Machado M. Machado	4	4/30/2023	SDP	vs	SFG	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
17	Brandon Dixon B. Dixon	4	4/14/2023	SDP	vs	MIL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
18	Matt Carpenter M. Carpenter	4	4/10/2023	SDP	@	NYM	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
19	Wil Myers W. Myers	4	9/11/2022	SDP	vs	LAD	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
20	Trent Grisham T. Grisham	4	8/23/2022	SDP	vs	CLE	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
21	Luke Voit L. Voit	4	6/24/2022	SDP	vs	PHI	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
22	Luke Voit L. Voit	4	6/16/2022	SDP	@	CHC	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
23	Luke Voit L. Voit	4	6/4/2022	SDP	@	MIL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
24	Jake Cronenworth J. Cronenworth	4	5/13/2022	SDP	@	ATL	6	1	1	0	0	0	0	0	0	0	0	6	1	0	0	0	0	0
25	Wil Myers W. Myers	4	9/25/2021	SDP	vs	ATL	5	1	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0