The San Diego Padres have a record of 294-321 against the Astros all-time.

	OPP	REC	W%	G	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	294-321	.478	615	294	321	20,766	2,400	5,125	846	125	386	2,261	1,920	154	3,852	449	187	23,269	7,379	1,357	269	160	187	411	.247	.313	.355	.668
2	Giants	461-497	.481	958	461	497	32,667	3,946	8,193	1,397	212	788	3,703	3,049	224	6,208	644	278	36,600	12,378	2,397	405	255	310	708	.251	.317	.379	.696
3	Dodgers	431-532	.448	964	431	532	32,178	3,438	7,548	1,305	123	698	3,216	2,948	214	6,918	657	283	36,017	11,193	2,126	437	240	307	669	.235	.301	.348	.649
4	Braves	297-371	.445	668	297	371	22,702	2,632	5,729	933	130	501	2,459	2,005	122	4,107	550	210	25,337	8,425	1,564	347	161	224	490	.252	.314	.371	.685
5	Reds	311-352	.469	664	311	352	22,396	2,687	5,601	1,034	133	510	2,524	2,197	133	4,116	423	185	25,212	8,431	1,677	314	172	235	492	.250	.319	.376	.695
6	Pirates	245-275	.471	520	245	275	17,686	2,135	4,463	783	112	399	2,014	1,738	123	3,260	345	188	19,933	6,667	1,294	250	136	176	392	.252	.321	.377	.698
7	Cardinals	217-305	.416	522	217	305	17,467	1,953	4,360	773	120	354	1,831	1,578	104	3,047	293	162	19,521	6,435	1,247	252	120	183	421	.250	.314	.368	.682
8	Cubs	239-285	.456	524	239	285	17,642	2,114	4,401	738	105	437	1,987	1,710	119	3,384	342	169	19,856	6,660	1,280	241	144	188	378	.249	.318	.378	.695
9	Mets	266-261	.505	527	266	261	17,607	2,014	4,328	739	94	413	1,880	1,629	109	3,643	367	164	19,709	6,494	1,246	241	123	165	387	.246	.312	.369	.680
10	Nationals	250-269	.482	519	250	269	17,629	2,096	4,386	697	111	436	1,978	1,666	126	3,351	411	169	19,783	6,613	1,244	244	118	150	348	.249	.316	.375	.691
11	Phillies	229-292	.440	521	229	292	17,753	2,134	4,499	850	131	400	1,991	1,706	107	3,362	352	146	19,886	6,811	1,381	191	129	152	379	.253	.320	.384	.704
12	Marlins	121-108	.528	229	121	108	7,676	985	1,918	377	53	178	923	842	74	1,677	155	75	8,753	2,935	608	89	72	67	156	.250	.327	.382	.709
13	Rockies	263-278	.486	541	263	278	18,552	2,737	4,999	1,016	127	602	2,606	1,926	176	3,752	326	111	20,973	8,075	1,745	162	157	120	489	.269	.341	.435	.776
14	Angels	23-25	.479	48	23	25	1,642	198	396	79	8	39	180	178	18	374	32	16	1,867	608	126	16	13	15	26	.241	.320	.370	.690
15	Rangers	32-25	.561	57	32	25	1,955	254	535	96	9	49	242	182	16	394	35	15	2,178	796	154	10	15	9	49	.274	.338	.407	.745
16	Athletics	22-27	.449	49	22	27	1,691	225	442	74	6	55	208	173	14	383	32	15	1,899	693	135	11	10	12	38	.261	.333	.410	.743
17	Mariners	64-73	.467	137	64	73	4,552	540	1,084	204	20	135	512	417	39	1,045	81	32	5,067	1,733	359	33	26	22	83	.238	.306	.381	.687
18	Diamondbacks	233-247	.485	480	233	247	16,152	2,079	3,975	779	88	514	1,979	1,539	151	3,772	263	112	18,079	6,472	1,381	118	119	85	324	.246	.315	.401	.716
19	Brewers	95-91	.511	186	95	91	6,353	835	1,646	270	35	194	790	665	41	1,451	143	41	7,165	2,568	499	60	46	48	150	.259	.331	.404	.735
20	Rays	11-19	.367	30	11	19	991	122	231	45	2	31	115	113	12	248	23	9	1,130	373	78	5	9	7	22	.233	.316	.376	.693
21	Orioles	14-16	.467	30	14	16	1,044	163	290	53	4	43	153	94	15	229	25	8	1,162	480	100	7	2	3	28	.278	.345	.460	.805
22	Red Sox	12-18	.400	30	12	18	979	100	219	46	2	22	97	97	14	229	16	6	1,101	335	70	8	3	2	13	.224	.302	.342	.644
23	Yankees	10-17	.370	27	10	17	899	96	205	39	2	21	91	90	11	240	18	5	1,011	311	62	2	9	4	10	.228	.303	.346	.649
24	Royals	16-11	.593	27	16	11	930	141	268	46	5	29	134	105	6	199	5	10	1,056	411	80	5	10	8	25	.288	.361	.442	.803
25	Tigers	12-15	.444	27	12	15	883	108	210	42	6	24	105	91	10	187	11	6	999	336	72	10	5	5	25	.238	.314	.381	.695