The 2022 roster for the Padres included Yu Darvish at pitcher, Austin Nola at catcher, Eric Hosmer at first baseman, Jake Cronenworth at second baseman and Manny Machado at third baseman.

	NO.	NAME	POS	HEIGHT	WEIGHT	DOB	AGE	BIRTHPLACE
1	77	CJ Abrams	SS	6'2"	185	10/3/2000	21	Alpharetta, GA
2	54	Austin Adams A. Adams	P	6'3"	225	5/5/1991	31	Tampa, FL
3	41	Sergio Alcántara S. Alcántara	3B	5'9"	170	7/10/1996	25	Santo Domingo Este, Dominican Republic
4	38	Jorge Alfaro J. Alfaro	C	6'2"	225	6/11/1993	29	Sincelejo, Colombia
5	60	Pedro Avila P. Avila	P	5'11"	190	1/14/1997	25	Caracas, Venezuela
6	28	José Azócar J. Azócar	RF	6'0"	185	5/11/1996	26	Guiria, Venezuela
7	49	Michel Baez M. Baez	P	6'8"	220	1/21/1996	26	Havana, Cuba
8	37	Matthew Batten M. Batten	2B	5'11"	180	6/22/1995	27	Shelton, CT
9	27	Matt Beaty M. Beaty	RF	6'0"	215	4/28/1993	29	Snellville, GA
10	24	Josh Bell J. Bell	1B	6'4"	250	8/14/1992	29	Irving, TX
11		Luis Campusano L. Campusano	C	5'10"	215	9/29/1998	23	Augusta, GA
12	24	Robinson Cano R. Cano	2B	6'0"	210	10/22/1982	39	San Pedro de Macoris, Dominican Republic
13		José Castillo J. Castillo	P	6'5"	246	1/10/1996	26	Valencia, Venezuela
14	52	Mike Clevinger M. Clevinger	P	6'4"	215	12/21/1990	31	Jacksonville, FL
15	61	Efraín Contreras E. Contreras	P			1/2/2000	22
16	74	Nabil Crismatt N. Crismatt	P	6'1"	215	12/25/1994	27	Barranquilla, Colombia
17	9	Jake Cronenworth J. Cronenworth	2B	6'1"	185	1/21/1994	28	St. Clair, MI
18	11	Yu Darvish Y. Darvish	P	6'5"	220	8/16/1986	35	Osaka, Japan
19	16	Brandon Dixon B. Dixon	2B	6'2"	215	1/29/1992	30	La Jolla, CA
20	17	Brandon Drury B. Drury	3B	6'2"	215	8/21/1992	29	Grants Pass, OR
21	66	Luis García L. García	P	6'2"	240	1/30/1987	35	Santo Domingo, Dominican Republic
22	1	MacKenzie Gore M. Gore	P	6'3"	195	2/24/1999	23	Whiteville, NC
23	2	Trent Grisham T. Grisham	CF	6'0"	205	11/1/1996	25	Fort Worth, TX
24	77	Jay Groome J. Groome	P	6'6"	220	8/23/1998	23	Barnegat, NJ
25	8	Javy Guerra J. Guerra	P	5'11"	155	9/25/1995	26	David, Panama