Walter Johnson has fanned the most career batters by a pitcher against a team, with 540 strikeouts versus the White Sox.

	NAME	SO	OPP	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	540	White Sox	125	63	39	.618	99	1.47	81	14	10	898.1	662		259	13	197	26	25			25	5.41	1.97	2.74	0.13		5.6	0.96	.238	2.59	6.63
2	Walter Johnson W. Johnson	521	Yankees	108	61	38	.616	94	1.61	78	21	3	846.1	687		261	23	209	30	14			31	5.54	2.22	2.49	0.24		6.2	1.06	.256	2.78	7.31
3	Walter Johnson W. Johnson	521	Tigers	124	66	42	.611	105	1.88	79	12	5	920.0	798		346	11	276	32	19			25	5.10	2.70	1.89	0.11		7.5	1.17	.277	3.38	7.81
4	Walter Johnson W. Johnson	516	Athletics	112	59	39	.602	93	1.81	74	23	4	826.0	715		277	22	185	26	17			20	5.62	2.02	2.79	0.24		5.5	1.09	.266	3.02	7.79
5	Walter Johnson W. Johnson	488	Red Sox	112	53	43	.552	91	1.62	75	15	6	815.0	670		233	6	180	31	20			12	5.39	1.99	2.71	0.07		5.6	1.04	.262	2.57	7.40
6	Walter Johnson W. Johnson	481	Browns	112	56	37	.602	91	1.61	73	13	3	801.2	658		253	12	179	33	18			20	5.40	2.01	2.69	0.13		5.6	1.04	.260	2.84	7.39
7	Steve Carlton S. Carlton	464	Mets	76	30	36	.455	76	3.12	27	4	0	550.2	483	191	213	37	190	4	0	8	2,274	12	7.58	3.11	2.44	0.60	20.4	8.4	1.22	.282	3.48	7.89
8	Walter Johnson W. Johnson	460	Indians	109	59	41	.590	93	1.89	71	12	3	809.1	727		273	10	148	30	15			22	5.12	1.65	3.11	0.11		4.5	1.08	.275	3.04	8.08
9	Steve Carlton S. Carlton	449	Pirates	78	39	25	.609	77	3.26	30	6	0	574.2	522	208	241	46	170	9	0	16	2,377	30	7.03	2.66	2.64	0.72	18.9	7.2	1.20	.280	3.77	8.18
10	Bob Feller B. Feller	427	Tigers	90	41	29	.586	79	3.44	48	6	3	631.0	538	241	276	47	307	12	5	0	2,672	6	6.09	4.38	1.39	0.67	16.0	11.5	1.34	.261	3.94	7.67
11	Clayton Kershaw C. Kershaw	421	Giants	63	27	16	.628	61	2.10	6	5	0	411.2	309	96	107	30	78	4	0	7	1,590	15	9.20	1.71	5.40	0.66	26.5	4.9	0.94	.264	2.34	6.76
12	Steve Carlton S. Carlton	421	Cubs	77	41	20	.672	72	3.11	29	7	0	533.0	487	184	212	49	156	10	2	16	2,207	16	7.11	2.63	2.70	0.83	19.1	7.1	1.21	.279	3.58	8.22
13	Warren Spahn W. Spahn	416	Giants	119	56	43	.566	108	3.24	67	6	3	861.1	788	310	334	100	241	8	9		3,531	11	4.35	2.52	1.73	1.04	11.8	6.8	1.19	.249	3.49	8.23
14	Christy Mathewson C. Mathewson	410	Braves	90	55	24	.696	78	1.19	63	14	3	687.0	598		209	9	133	7	9			16	5.37	1.74	3.08	0.12		4.9	1.06	.270	2.74	7.83
15	Don Drysdale D. Drysdale	404	Braves	79	30	25	.545	71	3.03	25	6	0	531.1	458	179	211	55	139	27	3	23	2,197	8	6.84	2.35	2.91	0.93	18.4	6.3	1.12	.256	3.57	7.76
16	Steve Carlton S. Carlton	398	Astros	61	33	13	.717	59	2.49	22	5	1	452.1	356	125	143	17	169	2	2	10	1,823	17	7.92	3.36	2.36	0.34	21.8	9.3	1.16	.274	2.85	7.08
17	Lefty Grove L. Grove	390	Tigers	102	60	19	.759	79	3.05	59	7	5	702.2	651	238	275	37	212	7	14		2,936	10	5.00	2.72	1.84	0.47	13.3	7.2	1.23	.268	3.52	8.34
18	Lefty Grove L. Grove	390	Yankees	92	34	26	.567	69	3.84	39	4	8	553.1	568	236	280	41	216	3	17		2,407	12	6.34	3.51	1.81	0.67	16.2	9.0	1.42	.300	4.55	9.24
19	Christy Mathewson C. Mathewson	386	Robins	77	49	19	.721	65	0.82	54	13	3	585.0	467		154	7	94	5	10			11	5.94	1.45	4.11	0.11		4.2	0.96	.260	2.37	7.18
20	Billy Pierce B. Pierce	383	Indians	88	37	29	.561	78	3.13	40	4	4	590.1	519	205	222	53	236	8	7	4	2,484	7	5.84	3.60	1.62	0.81	15.4	9.5	1.28	.258	3.38	7.91
21	Dazzy Vance D. Vance	383	Cubs	71	34	21	.618	55	3.28	32	4	2	467.0	430	170	192	27	130	7	9		1,924	4	7.38	2.51	2.95	0.52	19.9	6.8	1.20	.293	3.70	8.29
22	Warren Spahn W. Spahn	382	Pirates	104	49	34	.590	95	3.33	49	9	5	718.0	681	266	302	50	217	4	8		2,991	9	4.79	2.72	1.76	0.63	12.8	7.3	1.25	.270	3.79	8.54
23	Bob Feller B. Feller	381	Orioles	83	39	14	.736	69	2.73	44	7	5	557.0	451	169	184	27	236	2	10	0	2,315	12	6.16	3.81	1.61	0.44	16.5	10.2	1.23	.254	2.97	7.29
24	Eddie Plank E. Plank	379	Tigers	106	60	31	.659	92	1.47	75	11	4	788.0	761		293	7	185	25	14			15	4.33	2.11	2.05	0.08		6.1	1.20	.307	3.35	8.69
25	Christy Mathewson C. Mathewson	378	Pirates	107	54	38	.587	89	1.04	63	8	6	770.0	712		296	17	125	11	17			22	4.42	1.46	3.02	0.20		4.1	1.09	.277	3.46	8.32