Between the 1950 and 1959 seasons, Early Wynn fanned the most hitters, with 1,544 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Early Wynn E. Wynn	1,544	374	188	119	.612	339	3.28	162	33	12	2562.0	2,217	934	1,046	218	1,028	40	33	25	10,756	29	5.42	3.61	1.50	0.77	14.4	9.6	1.27	.252	3.67	86	3.61	95	7.79	54.9
2	Robin Roberts R. Roberts	1,516	405	199	149	.572	370	3.32	237	30	19	3011.2	2,874	1,110	1,229	327	525	29	29	31	12,263	22	4.53	1.57	2.89	0.98	12.4	4.3	1.13	.258	3.67	85	3.42	87	8.59	171.5
3	Billy Pierce B. Pierce	1,487	353	155	121	.562	306	3.06	162	33	18	2383.0	2,107	809	898	189	840	23	33	27	9,940	32	5.62	3.17	1.77	0.71	15.0	8.5	1.24	.259	3.39	78	3.34	86	7.96	145.8
4	Warren Spahn W. Spahn	1,464	389	202	131	.607	350	2.92	215	33	17	2822.2	2,540	915	1,022	222	790	20	33	36	11,554	43	4.67	2.52	1.85	0.71	12.7	6.8	1.18	.256	3.26	79	3.31	90	8.10	120.5
5	Harvey Haddix H. Haddix	1,093	245	95	80	.543	215	3.58	86	18	8	1572.0	1,494	626	704	179	414	30	23	39	6,539	33	6.26	2.37	2.64	1.02	16.7	6.3	1.21	.273	4.03	90	3.39	85	8.55	107.3
6	Bob Rush B. Rush	1,072	327	110	123	.472	278	3.57	105	15	3	2047.0	1,937	812	935	153	663	33	16	27	8,645	41	4.71	2.91	1.62	0.67	12.4	7.7	1.27	.265	4.11	90	3.40	85	8.52	136.2
7	Johnny Antonelli J. Antonelli	1,026	290	116	92	.558	241	3.18	98	23	9	1721.1	1,579	609	711	163	574	33	28	35	7,235	22	5.36	3.00	1.79	0.85	14.2	7.9	1.25	.260	3.72	81	3.55	91	8.26	68.6
8	Mike Garcia M. Garcia	1,000	355	128	91	.584	261	3.32	103	22	20	1960.1	1,945	724	814	113	636	30	55	20	8,331	26	4.59	2.92	1.57	0.52	12.0	7.6	1.32	.280	3.74	86	3.21	84	8.93	132.8
9	Sam Jones S. Jones	994	198	72	75	.490	164	3.52	60	14	6	1178.1	972	461	514	107	629	46	20	23	5,076	26	7.59	4.80	1.58	0.82	19.6	12.4	1.36	.262	3.93	90	3.66	93	7.42	37.2
10	Bob Turley B. Turley	983	207	83	63	.568	174	3.47	70	21	7	1269.2	973	489	525	96	804	40	22	10	5,495	27	6.97	5.70	1.22	0.68	17.9	14.6	1.40	.246	3.72	94	3.87	105	6.90	-30.3
11	Don Newcombe D. Newcombe	917	270	126	73	.633	246	3.54	116	19	5	1773.2	1,719	698	791	217	395	24	16	21	7,309	18	4.65	2.00	2.32	1.10	12.5	5.4	1.19	.261	4.01	87	3.73	90	8.72	79.5
12	Whitey Ford W. Ford	915	245	121	50	.708	208	2.66	94	24	8	1561.2	1,301	461	531	100	664	17	23	21	6,455	32	5.27	3.83	1.38	0.58	14.2	10.3	1.26	.252	3.06	71	3.43	92	7.50	51.8
13	Carl Erskine C. Erskine	903	296	108	74	.593	204	3.99	66	14	13	1575.0	1,518	699	758	188	560	13	49	13	6,659	37	5.16	3.20	1.61	1.07	13.6	8.4	1.32	.266	4.33	98	3.95	96	8.67	31.1
14	Bob Friend B. Friend	901	342	103	127	.448	262	3.88	89	16	6	1976.0	2,083	851	986	176	585	23	38	50	8,428	28	4.10	2.66	1.54	0.80	10.7	6.9	1.35	.283	4.49	98	3.62	91	9.49	74.3
15	Bob Lemon B. Lemon	888	311	150	94	.615	260	3.34	139	18	15	2015.1	1,890	749	872	141	820	44	35	13	8,589	48	3.97	3.66	1.08	0.63	10.3	9.5	1.34	.261	3.89	86	3.77	98	8.44	9.6
16	Curt Simmons C. Simmons	870	251	103	87	.542	223	3.44	99	18	3	1625.1	1,545	621	728	117	543	23	18	24	6,852	15	4.82	3.01	1.60	0.65	12.7	7.9	1.28	.269	4.03	88	3.37	85	8.56	102.5
17	Sal Maglie S. Maglie	830	290	114	58	.663	222	3.19	86	22	14	1638.2	1,519	581	662	167	540	42	34	8	6,841	18	4.56	2.97	1.54	0.92	12.1	7.9	1.26	.257	3.64	80	3.83	95	8.34	37.1
18	Billy Hoeft B. Hoeft	821	260	75	82	.478	182	4.09	71	16	11	1383.1	1,403	628	675	136	508	32	37	22	5,962	26	5.34	3.31	1.62	0.88	13.8	8.5	1.38	.284	4.39	105	3.70	95	9.13	32.1
19	Johnny Klippstein J. Klippstein	777	400	70	90	.438	152	4.55	37	6	28	1410.1	1,420	713	813	145	710	50	130	38	6,270	57	4.96	4.53	1.09	0.93	12.4	11.3	1.51	.278	5.19	111	4.30	105	9.06	-27.4
20	Murry Dickson M. Dickson	774	376	106	124	.461	230	3.83	100	18	16	1918.0	1,969	816	945	217	637	23	77	18	8,191	24	3.63	2.99	1.22	1.02	9.4	7.8	1.36	.268	4.43	94	4.15	101	9.24	-10.4
21	Virgil Trucks V. Trucks	774	302	90	72	.556	169	3.47	59	19	20	1400.2	1,290	540	594	107	597	33	77	19	5,987	35	4.97	3.84	1.30	0.69	12.9	10.0	1.35	.264	3.82	88	3.69	94	8.29	38.2
22	Camilo Pascual C. Pascual	748	222	45	76	.372	130	4.19	39	10	8	1028.2	1,014	479	521	80	425	27	55	24	4,470	26	6.54	3.72	1.76	0.70	16.7	9.5	1.40	.293	4.56	107	3.32	85	8.87	65.9
23	Vinegar Bend Mizell V. Bend Mizell	747	190	68	67	.504	176	3.68	51	11	0	1163.1	1,046	476	529	100	540	23	3	25	5,032	13	5.78	4.18	1.38	0.77	14.8	10.7	1.36	.261	4.09	91	3.76	94	8.09	35.5
24	Herb Score H. Score	742	115	49	34	.590	100	3.17	41	10	3	714.1	490	252	288	65	458	5	7	6	3,044	43	9.35	5.77	1.62	0.82	24.4	15.0	1.33	.240	3.63	81	3.47	89	6.17	35.3
25	Chuck Stobbs C. Stobbs	729	359	82	113	.421	202	4.28	54	6	15	1588.1	1,668	756	856	153	590	28	76	24	6,932	25	4.13	3.34	1.24	0.87	10.5	8.5	1.42	.279	4.85	106	3.96	99	9.45	9