Grover Alexander has won the most career games by a pitcher against a team, with 70 wins against the Reds.

Interpreted as:

pitcher most regular-season wins vs team in career

	NAME	W	OPP	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Grover Alexander G. Alexander	70	Reds	24	.745	108	96	2.04	326	74	20	4	847.0	736		246	10	152	13	12			6	3.46	1.62	2.14	0.11		4.6	1.05	.257	2.61	7.82
2	Walter Johnson W. Johnson	66	Tigers	42	.611	124	105	1.88	521	79	12	5	920.0	798		346	11	276	32	19			25	5.10	2.70	1.89	0.11		7.5	1.17	.277	3.38	7.81
3	Christy Mathewson C. Mathewson	65	Reds	19	.774	95	83	0.89	354	69	12	5	726.1	633		234	14	121	12	11			12	4.39	1.50	2.93	0.17		4.2	1.04	.263	2.90	7.84
4	Warren Spahn W. Spahn	64	Cardinals	41	.610	125	115	3.00	376	66	11	3	919.1	846	306	348	63	247	8	9		3,787	20	3.68	2.42	1.52	0.62	9.9	6.5	1.19	.253	3.41	8.28
5	Walter Johnson W. Johnson	63	White Sox	39	.618	125	99	1.47	540	81	14	10	898.1	662		259	13	197	26	25			25	5.41	1.97	2.74	0.13		5.6	0.96	.238	2.59	6.63
6	Warren Spahn W. Spahn	62	Reds	29	.681	113	95	2.94	373	59	9	4	773.2	715	253	284	68	206	8	14	14	3,183	11	4.34	2.40	1.81	0.79	11.7	6.5	1.19	.256	3.30	8.32
7	Walter Johnson W. Johnson	61	Yankees	38	.616	108	94	1.61	521	78	21	3	846.1	687		261	23	209	30	14			31	5.54	2.22	2.49	0.24		6.2	1.06	.256	2.78	7.31
8	Lefty Grove L. Grove	60	Tigers	19	.759	102	79	3.05	390	59	7	5	702.2	651	238	275	37	212	7	14		2,936	10	5.00	2.72	1.84	0.47	13.3	7.2	1.23	.268	3.52	8.34
9	Eddie Plank E. Plank	60	Tigers	31	.659	106	92	1.47	379	75	11	4	788.0	761		293	7	185	25	14			15	4.33	2.11	2.05	0.08		6.1	1.20	.307	3.35	8.69
10	Walter Johnson W. Johnson	59	Athletics	39	.602	112	93	1.81	516	74	23	4	826.0	715		277	22	185	26	17			20	5.62	2.02	2.79	0.24		5.5	1.09	.266	3.02	7.79
11	Walter Johnson W. Johnson	59	Indians	41	.590	109	93	1.89	460	71	12	3	809.1	727		273	10	148	30	15			22	5.12	1.65	3.11	0.11		4.5	1.08	.275	3.04	8.08
12	Grover Alexander G. Alexander	57	Braves	28	.671	105	83	2.06	318	66	11	7	755.2	692		246	22	115	8	18		3,039	5	3.79	1.37	2.77	0.26	10.5	3.8	1.07	.260	2.93	8.24
13	Warren Spahn W. Spahn	56	Giants	43	.566	119	108	3.24	416	67	6	3	861.1	788	310	334	100	241	8	9		3,531	11	4.35	2.52	1.73	1.04	11.8	6.8	1.19	.249	3.49	8.23
14	Grover Alexander G. Alexander	56	Robins	23	.709	95	81	2.02	308	63	16	6	723.0	654		233	13	122	6	13			8	3.83	1.52	2.52	0.16		4.2	1.07	.260	2.90	8.14
15	Walter Johnson W. Johnson	56	Browns	37	.602	112	91	1.61	481	73	13	3	801.2	658		253	12	179	33	18			20	5.40	2.01	2.69	0.13		5.6	1.04	.260	2.84	7.39
16	Christy Mathewson C. Mathewson	55	Braves	24	.696	90	78	1.19	410	63	14	3	687.0	598		209	9	133	7	9			16	5.37	1.74	3.08	0.12		4.9	1.06	.270	2.74	7.83
17	Christy Mathewson C. Mathewson	54	Pirates	38	.587	107	89	1.04	378	63	8	6	770.0	712		296	17	125	11	17			22	4.42	1.46	3.02	0.20		4.1	1.09	.277	3.46	8.32
18	Walter Johnson W. Johnson	53	Red Sox	43	.552	112	91	1.62	488	75	15	6	815.0	670		233	6	180	31	20			12	5.39	1.99	2.71	0.07		5.6	1.04	.262	2.57	7.40
19	Christy Mathewson C. Mathewson	52	Cardinals	22	.703	83	72	1.14	295	53	9	3	606.1	546		197	11	114	5	10			15	4.38	1.69	2.59	0.16		4.8	1.09	.271	2.92	8.10
20	Christy Mathewson C. Mathewson	52	Phillies	24	.684	82	77	0.84	334	57	9	0	630.1	572		212	12	127	10	5			16	4.77	1.81	2.63	0.17		5.1	1.11	.281	3.03	8.17
21	Ted Lyons T. Lyons	51	Indians	26	.662	89	70	2.86	132	57	3	2	632.0	644	201	249	22	148	7	15		2,635	7	1.88	2.11	0.89	0.31	5.0	5.6	1.25	.267	3.55	9.17
22	Red Faber R. Faber	51	Tigers	28	.646	109	83	3.07	228	51	8	2	662.0	672	226	291	15	212	16	15		2,816	9	3.10	2.88	1.08	0.20	8.1	7.5	1.34	.280	3.96	9.14
23	Warren Spahn W. Spahn	49	Pirates	34	.590	104	95	3.33	382	49	9	5	718.0	681	266	302	50	217	4	8		2,991	9	4.79	2.72	1.76	0.63	12.8	7.3	1.25	.270	3.79	8.54
24	Early Wynn E. Wynn	49	Athletics	25	.662	93	86	3.14	301	44	5	3	644.2	585	225	248	40	229	10	7	2	2,691	3	4.20	3.20	1.31	0.56	11.2	8.5	1.26	.258	3.46	8.17
25	Carl Hubbell C. Hubbell	49	Pirates	21	.700	83	73	3.03	215	48	5	3	579.2	585	195	229	26	120	8	9		2,424	9	3.34	1.86	1.79	0.40	8.9	5.0	1.22	.272	3.56	9.08