The Pittsburgh Pirates had their most strikeouts in a game versus the Phillies on September 22, 1958, with 21 strikeouts.

Interpreted as:

pittsburgh pirates most so in a regular-season game

	TEAM	SO	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	21	9/22/1958	PIT	@	PHI	L 2-3	49	2	9	0	0	1	2	2	0	0	0	53	12	1	1	1	0	0	.184	.212	.245	.456
2	Pirates	20	9/18/2022	PIT	@	NYM	L 3-7	32	3	5	2	0	1	3	0	1	0	0	33	10	3	0	0	0	0	.156	.182	.313	.494
3	Pirates	20	7/26/2011	PIT	@	ATL	L 3-4	66	3	13	0	1	1	3	7	0	4	2	76	18	2	3	0	3	0	.197	.274	.273	.547
4	Pirates	19	8/19/2012	PIT	@	STL	W 6-3	66	6	16	3	1	1	6	6	1	0	2	76	24	5	2	1	2	3	.242	.311	.364	.674
5	Pirates	19	4/28/2010	PIT	@	MIL	W 6-5	54	6	13	1	0	4	6	5	1	1	0	60	26	5	0	0	1	0	.241	.317	.481	.798
6	Pirates	19	9/30/1964	PIT	@	CIN	W 1-0	51	1	5	1	0	0	1	3	0	0	0	56	6	1	2	0	0	1	.098	.148	.118	.266
7	Pirates	18	7/24/2022	PIT	vs	MIA	L 5-6	36	5	6	0	0	1	5	4	1	1	0	42	9	1	0	1	0	0	.167	.262	.250	.512
8	Pirates	18	8/18/2013	PIT	vs	ARI	L 2-4	53	2	9	2	0	0	2	8	0	0	1	63	11	2	2	0	3	0	.170	.279	.208	.486
9	Pirates	17	3/28/2024	PIT	@	MIA	W 6-5	44	6	9	2	0	3	6	8	0	0	0	52	20	5	0	0	2	0	.205	.327	.455	.781
10	Pirates	17	5/27/2023	PIT	@	SEA	L 0-5	29	0	2	1	0	0	0	3	1	1	0	33	3	1	0	0	0	0	.069	.182	.103	.285
11	Pirates	17	6/24/2022	PIT	@	TBR	L 3-4	38	3	8	0	0	3	3	0	1	1	0	39	17	3	0	0	0	0	.211	.231	.447	.678
12	Pirates	17	5/14/2021	PIT	vs	SFG	W 3-2	38	3	7	2	1	0	3	2	0	0	0	41	11	3	0	1	2	0	.184	.220	.289	.509
13	Pirates	17	8/24/2018	PIT	@	MIL	L 6-7	60	6	17	4	0	0	5	7	1	1	0	70	21	4	1	1	3	1	.283	.362	.350	.712
14	Pirates	17	6/22/2018	PIT	vs	ARI	L 1-2	42	1	4	0	0	0	0	6	0	1	0	49	4	0	1	0	1	1	.095	.208	.095	.304
15	Pirates	17	5/8/2017	PIT	@	LAD	L 1-12	32	1	5	1	0	0	1	2	0	0	0	34	6	1	0	0	0	1	.156	.206	.188	.393
16	Pirates	17	7/17/2016	PIT	@	WSH	W 2-1	62	2	12	6	0	1	2	4	1	1	1	68	21	7	1	0	1	1	.194	.254	.339	.592
17	Pirates	17	4/24/2016	PIT	@	ARI	W 12-10	55	12	20	7	1	0	11	8	0	0	0	64	29	8	1	0	1	2	.364	.444	.527	.972
18	Pirates	17	6/14/2015	PIT	vs	PHI	W 1-0	41	1	9	1	0	0	1	3	1	1	0	46	10	1	1	0	2	0	.220	.289	.244	.533
19	Pirates	17	6/18/2013	PIT	@	CIN	W 4-0	30	4	4	0	1	0	4	6	0	3	0	37	6	1	1	0	0	0	.133	.278	.200	.478
20	Pirates	17	7/15/2012	PIT	@	MIL	L 1-4	32	1	5	1	0	1	1	0	0	0	0	32	9	2	0	0	0	0	.156	.156	.281	.438
21	Pirates	17	5/20/2012	PIT	@	DET	L 3-4	33	3	6	2	0	2	3	1	0	0	0	35	14	4	0	1	0	0	.182	.200	.424	.624
22	Pirates	17	5/6/2012	PIT	vs	CIN	L 0-5	32	0	3	0	0	0	0	3	1	0	0	36	3	0	0	0	0	0	.094	.194	.094	.288
23	Pirates	17	8/14/2010	PIT	@	HOU	L 2-3	33	2	6	0	1	1	2	1	1	2	0	36	11	2	1	0	1	0	.182	.229	.333	.562
24	Pirates	17	6/8/2010	PIT	@	WSH	L 2-5	31	2	5	0	0	1	2	0	0	1	0	31	8	1	0	0	0	1	.161	.161	.258	.419
25	Pirates	17	10/1/1999	PIT	@	NYM	L 2-3	39	2	7	0	0	0	2	4	1	0	0	45	7	0	1	0	1	0	.179	.273	.179	.452