Ty Cobb has collected the most career hits by a player against a team, with 619 hits versus the Yankees.

	NAME	H	OPP	G	AB	R	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Ty Cobb T. Cobb	619	Yankees	443	1,660	342	117	53	23		176	11		103		1,884	911	193	37				.373	.436	.549	.985
2	Ty Cobb T. Cobb	615	Red Sox	437	1,657	316	97	53	13		175	17		139		1,891	857	163	42				.371	.436	.517	.954
3	Ty Cobb T. Cobb	605	Senators	434	1,592	302	97	38	16		194	13		145		1,841	826	151	42				.380	.451	.519	.970
4	Ty Cobb T. Cobb	590	Athletics	397	1,552	316	104	44	13		170	9		131		1,774	821	161	43				.380	.444	.529	.973
5	Ty Cobb T. Cobb	580	Indians	432	1,654	319	105	34	15		160	14		135		1,858	798	154	35				.351		.482
6	Ty Cobb T. Cobb	575	White Sox	427	1,621	301	96	30	11		177	13		108		1,853	764	137	42				.355	.422	.471	.894
7	Ty Cobb T. Cobb	568	Browns	429	1,597	323	96	45	26		190	13		135		1,854	832	167	54				.356	.428	.521	.949
8	Stan Musial S. Musial	526	Pirates	426	1,546	275	108	27	58	253	238	5	79	14	4	1,806	862	193	8	9	21	31	.340	.428	.558	.985
9	Stan Musial S. Musial	522	Phillies	417	1,547	297	116	35	54	261	197	8	110	12	4	1,765	870	205	8	5	13	30	.337	.414	.562	.976
10	Stan Musial S. Musial	522	Dodgers	432	1,530	299	108	30	74	271	249	13	90	13	1	1,805	912	212	5	8	15	39	.341	.436	.596	1.032
11	Tristram Speaker T. Speaker	519	Browns	392	1,448	286	100	32	21		196	15		65		1,698	746	153	39				.358	.440	.515	.955
12	Stan Musial S. Musial	515	Braves	427	1,572	258	108	25	60	259	204	5	105	10	8	1,787	853	193	4	2	15	36	.328	.406	.543	.949
13	Tristram Speaker T. Speaker	511	White Sox	405	1,477	240	119	32	11		189	10		46		1,712	727	162	36				.346	.424	.492	.916
14	Tristram Speaker T. Speaker	511	Tigers	398	1,506	278	110	32	17		209	14		77		1,763	736	159	34				.339	.425	.489	.913
15	Stan Musial S. Musial	504	Giants	417	1,494	272	82	18	89	312	245	11	100	8	6	1,764	889	189	6	8	24	38	.337	.432	.595	1.027
16	Stan Musial S. Musial	500	Reds	428	1,574	275	92	22	66	275	224	7	94	9	4	1,815	834	180	4	6	24	36	.318	.404	.530	.934
17	Tristram Speaker T. Speaker	499	Yankees	410	1,517	284	120	24	27		185	13		66		1,762	748	171	47				.329	.406	.493	.899
18	Eddie Collins E. Collins	499	Tigers	405	1,430	292	69	24	5		242	11		125		1,760	631	98	77				.349	.447	.441	.888
19	Eddie Collins E. Collins	493	Red Sox	407	1,458	242	69	25	6		191	14		96		1,730	630	100	67				.338	.420	.432	.852
20	Stan Musial S. Musial	492	Cubs	422	1,550	252	104	19	67	286	217	4	106	11	4	1,784	835	190	1	12	12	36	.317	.400	.539	.939
21	Eddie Collins E. Collins	491	Indians	407	1,462	253	73	28	2		220	10		98		1,783	626	103	91				.336	.426	.428	.854
22	Eddie Collins E. Collins	489	Yankees	403	1,429	281	69	27	12		196	8		100		1,699	648	108	66				.342	.424	.453	.878
23	Pete Rose P. Rose	486	Braves	381	1,513	263	80	15	25	162	196	12	98	30	18	1,737	671	120	9	7	20	22	.321	.402	.443	.845
24	Tristram Speaker T. Speaker	479	Athletics	397	1,426	282	108	31	9		204	13		64		1,699	676	148	56				.336	.424	.474	.898
25	Eddie Collins E. Collins	478	Browns	394	1,400	287	52	34	12		220	15		120		1,706	634	98	71				.341	.436	.453	.889