Between the 1998 and 2020 seasons, Albert Pujols hit the most homers, with 662 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Albert Pujols A. Pujols	662	2,862	10,839	1,843	3,236	669	16	2,100	1,331	108	1,304	114	41	12,394	5,923	1,347	1	115	312	399	.299	.377	.546	.924	2141	668.4	.387	142	656.7
2	Alex Rodriguez A. Rodriguez	632	2,432	9,182	1,761	2,680	448	25	1,858	1,229	167	2,022	278	64	10,684	5,074	1,105	4	102	95	232	.292	.382	.553	.934	1917	620.6	.397	143	570.8
3	David Ortiz D. Ortiz	540	2,393	8,591	1,409	2,456	629	19	1,762	1,317	38	1,731	17	9	10,040	4,743	1,188	2	92	209	235	.286	.380	.552	.932	1753	559	.392	140	483.5
4	Miguel Cabrera M. Cabrera	487	2,457	9,153	1,457	2,866	581	17	1,729	1,159	64	1,812	39	21	10,467	4,942	1,085	5	86	235	321	.313	.391	.540	.931	1845	607.3	.393	145	568.5
5	Jim Thome J. Thome	479	1,896	6,279	1,164	1,711	331	14	1,313	1,317	48	1,978	4	9	7,697	3,507	824	0	53	144	114	.272	.400	.559	.958	1430	483.1	.404	145	437.9
6	Adrian Beltre A. Beltre	477	2,933	11,068	1,524	3,166	636	38	1,707	848	97	1,732	121	42	12,130	5,309	1,151	14	103	112	279	.286	.339	.480	.819	1705	256.1	.350	115	216.7
7	Adam Dunn A. Dunn	462	2,001	6,883	1,097	1,631	334	10	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
8	Manny Ramirez M. Ramirez	446	1,750	6,306	1,210	1,984	413	16	1,459	1,046	94	1,402	18	17	7,514	3,767	875	0	68	193	184	.315	.416	.597	1.013	1515	588.2	.423	157	545.1
9	Paul Konerko P. Konerko	439	2,343	8,386	1,162	2,339	410	8	1,412	920	104	1,389	9	4	9,497	4,082	857	1	86	80	281	.279	.354	.487	.841	1420	274.2	.361	118	214.9
10	Vladimir Guerrero V. Guerrero	437	2,048	7,803	1,282	2,487	455	44	1,455	718	96	943	178	90	8,678	4,341	936	0	61	248	265	.319	.380	.556	.937	1522	459.1	.392	137	414.8
11	Carlos Beltran C. Beltran	435	2,586	9,768	1,582	2,725	565	78	1,587	1,084	51	1,795	312	49	11,031	4,751	1,078	18	110	104	203	.279	.350	.486	.837	1621	297.8	.358	118	246.4
12	Edwin Encarnacion E. Encarnacion	424	1,960	7,040	1,099	1,832	370	10	1,261	903	105	1,426	61	14	8,114	3,494	804	0	66	54	185	.260	.350	.496	.846	1233	280.2	.362	125	235.4
13	Nelson Cruz N. Cruz	417	1,742	6,397	952	1,777	330	13	1,152	632	73	1,625	76	32	7,151	3,384	760	2	47	66	147	.278	.347	.529	.876	1143	309.1	.371	133	281.2
14	Alfonso Soriano A. Soriano	412	1,975	7,750	1,152	2,095	481	31	1,159	496	86	1,803	289	84	8,395	3,874	924	9	54	68	123	.270	.319	.500	.819	1163	161.7	.348	111	112.7
15	Andruw Jones A. Jones	411	2,012	7,094	1,133	1,818	358	34	1,206	828	93	1,612	129	48	8,084	3,477	803	1	68	67	180	.256	.339	.490	.829	1162	165.6	.354	112	127.5
16	Mark Teixeira M. Teixeira	409	1,862	6,936	1,099	1,862	408	18	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869	1268	317.6	.371	127	262.4
17	Carlos Delgado C. Delgado	406	1,662	6,054	1,070	1,727	408	13	1,294	955	152	1,401	13	4	7,239	3,379	827	0	78	171	127	.285	.391	.558	.950	1309	410.1	.398	141	377.5
18	Sammy Sosa S. Sosa	402	1,266	4,792	882	1,373	217	12	1,025	652	27	1,279	35	25	5,522	2,820	631	0	51	112	118	.287	.372	.588	.960	1005	315.7	.399	141	293.1
19	Jason Giambi J. Giambi	394	1,924	6,036	1,050	1,657	317	6	1,256	1,232	166	1,357	18	9	7,512	3,168	717	0	78	91	136	.275	.407	.525	.932	1369	446.2	.400	144	421.8
20	Chipper Jones C. Jones	394	2,037	7,262	1,316	2,224	453	27	1,316	1,275	18	1,133	108	36	8,636	3,913	874	1	80	168	210	.306	.407	.539	.946	1585	528.1	.402	145	495.8
21	Barry Bonds B. Bonds	388	1,244	3,778	983	1,185	242	21	902	1,331	64	581	97	23	5,203	2,633	651	1	29	428	70	.314	.496	.697	1.193	1290	640.8	.476	194	631.4
22	Aramis Ramirez A. Ramirez	386	2,194	8,136	1,098	2,303	495	24	1,417	633	127	1,238	29	18	8,986	4,004	905	3	87	58	233	.283	.341	.492	.833	1310	239	.357	115	169.8
23	Ryan Howard R. Howard	382	1,572	5,707	848	1,475	277	21	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
24	Lance Berkman L. Berkman	366	1,879	6,491	1,146	1,905	422	30	1,234	1,201	66	1,300	86	48	7,813	3,485	818	1	54	160	147	.293	.406	.537	.943	1424	477.5	.400	144	432.3
25	Todd Helton T. Helton	364	2,212	7,869	1,388	2,493	590	36	1,395	1,327	57	1,164	37	28	9,349	4,247	990	3	93	185	185	.317	.415	.540	.955	1750	610.4	.406	132	390.6