Rickey Henderson has the most career doubles when leading off a game, with 117 doubles.

	NAME	2B	G	AB	H	3B	HR	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	117	2,875	2,462	680	17	81	81	394	19	408	2,875	1,074	215	0	0	0	.276	.380	.436	.816
2	Craig Biggio C. Biggio	106	1,560	1,407	400	9	53	53	114	39	233	1,560	683	168	0	0	0	.284	.354	.485	.840
3	Jimmy Rollins J. Rollins	91	1,507	1,438	386	10	46	46	65	4	179	1,507	635	147	0	0	0	.268	.302	.442	.744
4	Ichiro Suzuki I. Suzuki	80	1,822	1,750	544	16	37	37	65	7	182	1,822	767	133	0	0	0	.311	.338	.438	.776
5	Paul Molitor P. Molitor	78	1,570	1,451	423	19	33	33	111	8	188	1,570	638	130	0	0	0	.292	.345	.440	.785
6	Jose Reyes J. Reyes	75	1,445	1,359	393	16	26	26	86	0	181	1,445	578	117	0	0	0	.289	.331	.425	.757
7	Brian Roberts B. Roberts	74	1,133	1,037	277	3	13	13	96	0	138	1,133	396	90	0	0	0	.267	.329	.382	.711
8	Mookie Betts M. Betts	69	1,080	985	282	9	52	52	88	7	181	1,080	525	130	0	0	1	.286	.349	.533	.882
9	Kenny Lofton K. Lofton	68	1,705	1,487	448	22	29	29	211	7	227	1,705	647	119	0	0	0	.301	.391	.435	.826
10	Brady Anderson B. Anderson	63	1,294	1,139	298	10	44	44	132	23	196	1,294	513	117	0	0	0	.262	.350	.450	.800
11	Johnny Damon J. Damon	62	1,575	1,422	388	13	27	27	147	6	201	1,575	557	102	0	0	0	.273	.343	.392	.735
12	Shannon Stewart S. Stewart	61	1,169	1,075	309	7	23	23	81	13	134	1,169	453	91	0	0	0	.287	.345	.421	.766
13	Tim Raines T. Raines	60	1,398	1,252	361	26	16	16	137	9	146	1,398	521	102	0	0	0	.288	.363	.416	.779
14	Eric Young E. Young	59	1,242	1,097	296	14	20	20	128	17	112	1,242	443	93	0	0	0	.270	.355	.404	.759
15	Alfonso Soriano A. Soriano	58	768	723	224	2	54	54	33	12	141	768	448	114	0	0	0	.310	.350	.620	.970
16	Denard Span D. Span	57	1,157	1,042	257	8	15	15	112	3	157	1,157	375	80	0	0	0	.247	.322	.360	.681
17	Tony Phillips T. Phillips	56	1,381	1,187	317	7	30	30	190	4	249	1,381	477	93	0	0	0	.267	.370	.402	.772
18	Pete Rose P. Rose	56	1,097	1,001	285	3	5	5	87	9	60	1,097	362	64	0	0	0	.285	.347	.362	.709
19	Ray Durham R. Durham	55	975	888	269	14	34	34	81	6	147	975	454	103	0	0	0	.303	.365	.511	.876
20	Brett Butler B. Butler	55	1,844	1,637	473	22	8	8	202	5	174	1,844	596	85	0	0	0	.289	.369	.364	.733
21	Jose Altuve J. Altuve	54	927	854	273	3	41	41	64	9	126	927	456	98	0	0	0	.320	.373	.534	.907
22	Charlie Blackmon C. Blackmon	54	1,011	945	274	10	42	42	55	11	215	1,011	474	106	0	0	0	.290	.336	.502	.838
23	Rafael Furcal R. Furcal	54	1,389	1,301	363	13	30	30	85	2	181	1,389	533	97	0	0	0	.279	.324	.410	.734
24	Lenny Dykstra L. Dykstra	54	1,095	951	236	13	20	20	136	8	132	1,095	376	87	0	0	0	.248	.347	.395	.742
25	David DeJesus D. DeJesus	53	890	798	208	8	15	15	73	19	148	890	322	76	0	0	0	.261	.337	.404	.741