| NAME | IP | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | T. Wakefield | 3006.0 | 590 | 186 | 168 | .525 | 430 | 4.43 | 2,046 | 26 | 3 | 22 | 2,931 | 1,480 | 1,682 | 401 | 1,095 | 176 | 77 | 30 | 12,971 | 125 | 6.13 | 3.28 | 1.87 | 1.20 | 15.8 | 8.4 | 1.34 | .273 | 5.04 | 95 | 4.73 | 108 | 8.78 | -118.5 | |
| 2 | R. Clemens | 2642.2 | 362 | 183 | 107 | .631 | 362 | 2.99 | 2,464 | 95 | 37 | 0 | 2,213 | 879 | 978 | 181 | 827 | 84 | 0 | 40 | 10,809 | 68 | 8.39 | 2.82 | 2.98 | 0.62 | 22.8 | 7.7 | 1.15 | .280 | 3.33 | 68 | 2.94 | 70 | 7.54 | 370.2 | |
| 3 | J. Lester | 1519.1 | 242 | 110 | 63 | .636 | 241 | 3.64 | 1,386 | 10 | 3 | 0 | 1,426 | 615 | 655 | 138 | 529 | 55 | 0 | 4 | 6,378 | 38 | 8.21 | 3.13 | 2.62 | 0.82 | 21.7 | 8.3 | 1.29 | .302 | 3.88 | 84 | 3.60 | 88 | 8.45 | 81.9 | |
| 4 | P. Martinez | 1383.2 | 203 | 117 | 37 | .760 | 201 | 2.52 | 1,683 | 22 | 8 | 0 | 1,044 | 387 | 428 | 103 | 309 | 77 | 1 | 5 | 5,498 | 30 | 10.95 | 2.01 | 5.45 | 0.67 | 30.6 | 5.6 | 0.98 | .283 | 2.78 | 53 | 2.44 | 55 | 6.79 | 316.2 | |
| 5 | J. Beckett | 1240.0 | 194 | 89 | 58 | .605 | 194 | 4.17 | 1,108 | 7 | 3 | 0 | 1,179 | 574 | 604 | 153 | 338 | 53 | 0 | 9 | 5,190 | 35 | 8.04 | 2.45 | 3.28 | 1.11 | 21.3 | 6.5 | 1.22 | .290 | 4.38 | 93 | 3.87 | 92 | 8.56 | 46.7 | |
| 6 | C. Buchholz | 1167.2 | 206 | 81 | 61 | .570 | 188 | 3.96 | 899 | 9 | 6 | 0 | 1,104 | 514 | 565 | 116 | 417 | 45 | 7 | 9 | 4,920 | 28 | 6.93 | 3.21 | 2.16 | 0.89 | 18.3 | 8.5 | 1.30 | .287 | 4.35 | 93 | 4.04 | 100 | 8.51 | -0.4 | |
| 7 | D. Lowe | 1037.0 | 384 | 70 | 55 | .560 | 111 | 3.72 | 673 | 2 | 1 | 85 | 1,024 | 429 | 488 | 69 | 312 | 48 | 154 | 27 | 4,389 | 26 | 5.84 | 2.71 | 2.16 | 0.60 | 15.3 | 7.1 | 1.29 | .291 | 4.24 | 79 | 3.66 | 83 | 8.89 | 87.3 | |
| 8 | R. Porcello | 964.0 | 159 | 73 | 55 | .570 | 159 | 4.43 | 852 | 6 | 0 | 0 | 1,000 | 475 | 524 | 144 | 211 | 51 | 0 | 3 | 4,088 | 28 | 7.95 | 1.97 | 4.04 | 1.34 | 20.8 | 5.2 | 1.26 | .302 | 4.89 | 99 | 4.14 | 98 | 9.34 | 10 | |
| 9 | B. Hurst | 859.0 | 126 | 57 | 40 | .588 | 121 | 3.96 | 712 | 39 | 9 | 0 | 873 | 378 | 408 | 105 | 261 | 9 | 0 | 12 | 3,617 | 17 | 7.46 | 2.73 | 2.73 | 1.10 | 19.7 | 7.2 | 1.32 | .304 | 4.27 | 92 | 3.64 | 89 | 9.15 | 42.5 | |
| 10 | E. Rodriguez | 856.2 | 159 | 64 | 39 | .621 | 153 | 4.16 | 892 | 0 | 0 | 0 | 831 | 396 | 410 | 107 | 294 | 25 | 1 | 6 | 3,649 | 9 | 9.37 | 3.09 | 3.03 | 1.12 | 24.4 | 8.1 | 1.31 | .311 | 4.31 | 92 | 3.82 | 89 | 8.73 | 44 | |
| 11 | O. Can Boyd | 712.0 | 105 | 44 | 35 | .557 | 105 | 4.20 | 392 | 24 | 3 | 0 | 746 | 332 | 360 | 97 | 181 | 10 | 0 | 7 | 2,999 | 6 | 4.96 | 2.29 | 2.17 | 1.23 | 13.1 | 6.0 | 1.30 | .280 | 4.55 | 100 | 4.21 | 105 | 9.43 | -17 | |
| 12 | J. Lackey | 701.2 | 111 | 47 | 43 | .522 | 111 | 4.46 | 541 | 3 | 0 | 0 | 752 | 348 | 373 | 79 | 200 | 34 | 0 | 3 | 3,023 | 21 | 6.94 | 2.57 | 2.71 | 1.01 | 17.9 | 6.6 | 1.36 | .310 | 4.78 | 106 | 3.98 | 101 | 9.65 | -3.5 | |
| 13 | C. Schilling | 675.0 | 119 | 53 | 29 | .646 | 98 | 3.95 | 574 | 4 | 1 | 9 | 712 | 296 | 301 | 84 | 108 | 13 | 21 | 2 | 2,795 | 5 | 7.65 | 1.44 | 5.31 | 1.12 | 20.5 | 3.9 | 1.21 | .312 | 4.01 | 85 | 3.56 | 82 | 9.49 | 60.3 | |
| 14 | C. Sale | 670.2 | 115 | 46 | 30 | .605 | 115 | 3.27 | 945 | 2 | 1 | 0 | 527 | 244 | 266 | 80 | 156 | 48 | 0 | 1 | 2,713 | 12 | 12.68 | 2.09 | 6.06 | 1.07 | 34.8 | 5.8 | 1.02 | .301 | 3.57 | 71 | 2.82 | 65 | 7.07 | 113.5 | |
| 15 | D. Matsuzaka | 668.1 | 117 | 50 | 37 | .575 | 116 | 4.52 | 609 | 1 | 0 | 0 | 627 | 336 | 347 | 75 | 321 | 34 | 1 | 4 | 2,919 | 25 | 8.20 | 4.32 | 1.90 | 1.01 | 20.9 | 11.0 | 1.42 | .294 | 4.67 | 101 | 4.36 | 104 | 8.44 | -13.1 | |
| 16 | G. Harris | 651.0 | 287 | 39 | 43 | .476 | 53 | 3.91 | 489 | 3 | 0 | 16 | 601 | 283 | 318 | 48 | 304 | 26 | 80 | 45 | 2,820 | 35 | 6.76 | 4.20 | 1.61 | 0.66 | 17.3 | 10.8 | 1.39 | .283 | 4.40 | 90 | 3.84 | 94 | 8.31 | 18 | |
| 17 | N. Pivetta | 633.0 | 131 | 37 | 41 | .474 | 107 | 4.29 | 718 | 1 | 0 | 2 | 558 | 302 | 312 | 103 | 229 | 17 | 4 | 4 | 2,658 | 28 | 10.21 | 3.26 | 3.14 | 1.46 | 27.0 | 8.6 | 1.24 | .286 | 4.44 | 99 | 4.18 | 100 | 7.93 | 0.4 | |
| 18 | A. Sele | 622.0 | 108 | 38 | 33 | .535 | 108 | 4.41 | 478 | 4 | 0 | 0 | 660 | 305 | 349 | 60 | 269 | 42 | 0 | 10 | 2,777 | 21 | 6.92 | 3.89 | 1.78 | 0.87 | 17.2 | 9.7 | 1.49 | .311 | 5.05 | 91 | 4.32 | 94 | 9.55 | 18.5 | |
| 19 | D. Price | 588.0 | 103 | 46 | 24 | .657 | 98 | 3.84 | 609 | 3 | 0 | 0 | 552 | 251 | 268 | 78 | 156 | 24 | 1 | 1 | 2,448 | 10 | 9.32 | 2.39 | 3.90 | 1.19 | 24.9 | 6.4 | 1.20 | .300 | 4.10 | 85 | 3.73 | 87 | 8.45 | 35.6 | |
| 20 | B. Bello | 543.1 | 100 | 39 | 36 | .520 | 97 | 4.09 | 464 | 2 | 0 | 0 | 544 | 247 | 266 | 60 | 195 | 32 | 0 | 1 | 2,338 | 14 | 7.69 | 3.23 | 2.38 | 0.99 | 19.8 | 8.3 | 1.36 | .305 | 4.41 | 94 | 4.15 | 99 | 9.01 | 2.8 | |
| 21 | D. Darwin | 534.1 | 110 | 34 | 31 | .523 | 74 | 4.14 | 350 | 4 | 1 | 3 | 527 | 246 | 262 | 70 | 141 | 13 | 21 | 24 | 2,249 | 12 | 5.90 | 2.37 | 2.48 | 1.18 | 15.6 | 6.3 | 1.25 | .273 | 4.41 | 93 | 4.18 | 99 | 8.88 | 2.8 | |
| 22 | M. Boddicker | 528.2 | 83 | 39 | 22 | .639 | 82 | 3.49 | 344 | 8 | 3 | 0 | 527 | 205 | 223 | 38 | 166 | 23 | 0 | 11 | 2,233 | 17 | 5.86 | 2.83 | 2.07 | 0.65 | 15.4 | 7.4 | 1.31 | .294 | 3.80 | 86 | 3.48 | 90 | 8.97 | 23.2 | |
| 23 | B. Stanley | 503.2 | 248 | 27 | 33 | .450 | 21 | 4.15 | 256 | 4 | 1 | 35 | 575 | 232 | 269 | 43 | 149 | 11 | 149 | 34 | 2,177 | 11 | 4.57 | 2.66 | 1.72 | 0.77 | 11.8 | 6.8 | 1.44 | .310 | 4.81 | 97 | 3.82 | 94 | 10.27 | 13.5 | |
| 24 | T. Gordon | 495.1 | 170 | 25 | 25 | .500 | 59 | 4.45 | 432 | 6 | 2 | 68 | 476 | 245 | 263 | 42 | 220 | 8 | 100 | 9 | 2,171 | 20 | 7.85 | 4.00 | 1.96 | 0.76 | 19.9 | 10.1 | 1.41 | .295 | 4.78 | 91 | 3.87 | 83 | 8.65 | 42.5 | |
| 25 | J. Hesketh | 495.0 | 134 | 31 | 26 | .544 | 69 | 4.04 | 351 | 1 | 0 | 2 | 520 | 222 | 260 | 49 | 197 | 4 | 19 | 20 | 2,153 | 27 | 6.38 | 3.58 | 1.78 | 0.89 | 16.3 | 9.2 | 1.45 | .303 | 4.73 | 92 | 3.99 | 95 | 9.45 | 11.4 | |