| NAME | IP | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | C. Buchholz | 977.0 | 170 | 69 | 47 | .595 | 154 | 3.78 | 737 | 7 | 5 | 0 | 906 | 410 | 452 | 92 | 330 | 40 | 7 | 7 | 4,076 | 25 | 6.79 | 3.04 | 2.23 | 0.85 | 18.1 | 8.1 | 1.27 | .283 | 4.16 | 90 | 3.94 | 99 | 8.35 | 4.9 | |
| 2 | R. Porcello | 964.0 | 159 | 73 | 55 | .570 | 159 | 4.43 | 852 | 6 | 0 | 0 | 1,000 | 475 | 524 | 144 | 211 | 51 | 0 | 3 | 4,088 | 28 | 7.95 | 1.97 | 4.04 | 1.34 | 20.8 | 5.2 | 1.26 | .302 | 4.89 | 99 | 4.14 | 98 | 9.34 | 10 | |
| 3 | J. Lester | 961.1 | 150 | 68 | 47 | .591 | 150 | 3.63 | 899 | 6 | 1 | 0 | 886 | 388 | 421 | 87 | 325 | 36 | 0 | 2 | 4,019 | 23 | 8.42 | 3.04 | 2.77 | 0.81 | 22.4 | 8.1 | 1.26 | .299 | 3.94 | 86 | 3.50 | 88 | 8.29 | 49.7 | |
| 4 | E. Rodriguez | 856.2 | 159 | 64 | 39 | .621 | 153 | 4.16 | 892 | 0 | 0 | 0 | 831 | 396 | 410 | 107 | 294 | 25 | 1 | 6 | 3,649 | 9 | 9.37 | 3.09 | 3.03 | 1.12 | 24.4 | 8.1 | 1.31 | .311 | 4.31 | 92 | 3.82 | 89 | 8.73 | 44 | |
| 5 | J. Lackey | 701.2 | 111 | 47 | 43 | .522 | 111 | 4.46 | 541 | 3 | 0 | 0 | 752 | 348 | 373 | 79 | 200 | 34 | 0 | 3 | 3,023 | 21 | 6.94 | 2.57 | 2.71 | 1.01 | 17.9 | 6.6 | 1.36 | .310 | 4.78 | 106 | 3.98 | 101 | 9.65 | -3.5 | |
| 6 | C. Sale | 670.2 | 115 | 46 | 30 | .605 | 115 | 3.27 | 945 | 2 | 1 | 0 | 527 | 244 | 266 | 80 | 156 | 48 | 0 | 1 | 2,713 | 12 | 12.68 | 2.09 | 6.06 | 1.07 | 34.8 | 5.8 | 1.02 | .301 | 3.57 | 71 | 2.82 | 65 | 7.07 | 113.5 | |
| 7 | N. Pivetta | 633.0 | 131 | 37 | 41 | .474 | 107 | 4.29 | 718 | 1 | 0 | 2 | 558 | 302 | 312 | 103 | 229 | 17 | 4 | 4 | 2,658 | 28 | 10.21 | 3.26 | 3.14 | 1.46 | 27.0 | 8.6 | 1.24 | .286 | 4.44 | 99 | 4.18 | 100 | 7.93 | 0.4 | |
| 8 | D. Price | 588.0 | 103 | 46 | 24 | .657 | 98 | 3.84 | 609 | 3 | 0 | 0 | 552 | 251 | 268 | 78 | 156 | 24 | 1 | 1 | 2,448 | 10 | 9.32 | 2.39 | 3.90 | 1.19 | 24.9 | 6.4 | 1.20 | .300 | 4.10 | 85 | 3.73 | 87 | 8.45 | 35.6 | |
| 9 | B. Bello | 543.1 | 100 | 39 | 36 | .520 | 97 | 4.09 | 464 | 2 | 0 | 0 | 544 | 247 | 266 | 60 | 195 | 32 | 0 | 1 | 2,338 | 14 | 7.69 | 3.23 | 2.38 | 0.99 | 19.8 | 8.3 | 1.36 | .305 | 4.41 | 94 | 4.15 | 99 | 9.01 | 2.8 | |
| 10 | T. Houck | 474.1 | 113 | 24 | 32 | .429 | 80 | 3.97 | 449 | 1 | 1 | 9 | 429 | 209 | 233 | 43 | 158 | 40 | 16 | 5 | 2,004 | 12 | 8.52 | 3.00 | 2.84 | 0.82 | 22.4 | 7.9 | 1.24 | .294 | 4.42 | 91 | 3.71 | 88 | 8.14 | 25.8 | |
| 11 | N. Eovaldi | 461.2 | 96 | 26 | 18 | .591 | 84 | 4.05 | 468 | 2 | 1 | 0 | 477 | 208 | 230 | 63 | 109 | 17 | 2 | 2 | 1,956 | 19 | 9.12 | 2.12 | 4.29 | 1.23 | 23.9 | 5.6 | 1.27 | .319 | 4.48 | 90 | 3.72 | 87 | 9.30 | 27.6 | |
| 12 | J. Beckett | 448.0 | 72 | 24 | 24 | .500 | 72 | 4.38 | 385 | 1 | 1 | 0 | 428 | 218 | 229 | 57 | 135 | 22 | 0 | 6 | 1,891 | 13 | 7.73 | 2.71 | 2.85 | 1.15 | 20.4 | 7.1 | 1.26 | .287 | 4.60 | 102 | 4.04 | 100 | 8.60 | -0.7 | |
| 13 | M. Barnes | 431.2 | 429 | 32 | 30 | .516 | 2 | 4.07 | 556 | 0 | 0 | 47 | 379 | 195 | 209 | 50 | 200 | 17 | 134 | 8 | 1,862 | 43 | 11.59 | 4.17 | 2.78 | 1.04 | 29.9 | 10.7 | 1.34 | .317 | 4.36 | 91 | 3.59 | 85 | 7.90 | 31.2 | |
| 14 | F. Doubront | 418.0 | 98 | 26 | 22 | .542 | 69 | 4.82 | 378 | 0 | 0 | 3 | 431 | 224 | 247 | 51 | 186 | 13 | 8 | 0 | 1,851 | 20 | 8.14 | 4.00 | 2.03 | 1.10 | 20.4 | 10.0 | 1.48 | .311 | 5.32 | 115 | 4.28 | 109 | 9.28 | -16.1 | |
| 15 | K. Crawford | 392.1 | 86 | 17 | 31 | .354 | 69 | 4.56 | 389 | 0 | 0 | 0 | 348 | 199 | 210 | 64 | 118 | 16 | 8 | 1 | 1,633 | 12 | 8.92 | 2.71 | 3.30 | 1.47 | 23.8 | 7.2 | 1.19 | .272 | 4.82 | 106 | 4.34 | 105 | 7.98 | -7.5 | |
| 16 | J. Kelly | 359.1 | 182 | 26 | 11 | .703 | 41 | 4.33 | 319 | 0 | 0 | 2 | 335 | 173 | 181 | 32 | 164 | 18 | 29 | 1 | 1,557 | 17 | 7.99 | 4.11 | 1.95 | 0.80 | 20.5 | 10.5 | 1.39 | .296 | 4.53 | 102 | 4.04 | 100 | 8.39 | 0.3 | |
| 17 | S. Wright | 347.2 | 81 | 24 | 16 | .600 | 44 | 3.86 | 271 | 4 | 1 | 1 | 330 | 149 | 175 | 43 | 132 | 15 | 15 | 3 | 1,481 | 16 | 7.02 | 3.42 | 2.05 | 1.11 | 18.3 | 8.9 | 1.33 | .281 | 4.53 | 88 | 4.45 | 108 | 8.54 | -13.2 | |
| 18 | D. Pomeranz | 316.1 | 72 | 22 | 17 | .564 | 56 | 4.24 | 311 | 0 | 0 | 0 | 323 | 149 | 157 | 45 | 137 | 8 | 6 | 2 | 1,376 | 13 | 8.85 | 3.90 | 2.27 | 1.28 | 22.6 | 10.0 | 1.45 | .318 | 4.47 | 94 | 4.41 | 103 | 9.19 | -4.8 | |
| 19 | G. Whitlock | 313.2 | 165 | 25 | 14 | .641 | 23 | 3.13 | 343 | 0 | 0 | 10 | 279 | 109 | 122 | 32 | 76 | 13 | 33 | 4 | 1,281 | 10 | 9.84 | 2.18 | 4.51 | 0.92 | 26.8 | 5.9 | 1.13 | .302 | 3.50 | 72 | 3.15 | 75 | 8.01 | 36.3 | |
| 20 | B. Workman | 308.0 | 214 | 25 | 16 | .610 | 18 | 3.83 | 317 | 0 | 0 | 20 | 264 | 131 | 144 | 32 | 141 | 4 | 62 | 9 | 1,297 | 8 | 9.26 | 4.12 | 2.25 | 0.94 | 24.4 | 10.9 | 1.31 | .289 | 4.21 | 89 | 3.85 | 94 | 7.71 | 9.8 | |
| 21 | T. Wakefield | 294.2 | 65 | 11 | 18 | .379 | 42 | 5.22 | 177 | 1 | 0 | 0 | 316 | 171 | 202 | 44 | 83 | 13 | 16 | 4 | 1,287 | 26 | 5.41 | 2.54 | 2.13 | 1.34 | 13.8 | 6.4 | 1.35 | .280 | 6.17 | 122 | 4.76 | 118 | 9.65 | -24.3 | |
| 22 | J. Tazawa | 286.2 | 296 | 15 | 17 | .469 | 0 | 3.23 | 295 | 0 | 0 | 4 | 280 | 103 | 108 | 30 | 62 | 5 | 55 | 4 | 1,185 | 21 | 9.26 | 1.95 | 4.76 | 0.94 | 24.9 | 5.2 | 1.19 | .315 | 3.39 | 77 | 3.11 | 79 | 8.79 | 27.2 | |
| 23 | H. Hembree | 257.2 | 251 | 15 | 5 | .750 | 0 | 3.70 | 270 | 0 | 0 | 2 | 255 | 106 | 123 | 41 | 97 | 5 | 53 | 8 | 1,116 | 10 | 9.43 | 3.39 | 2.78 | 1.43 | 24.2 | 8.7 | 1.37 | .304 | 4.30 | 82 | 4.32 | 102 | 8.91 | -2.1 | |
| 24 | J. Winckowski | 242.1 | 121 | 13 | 14 | .481 | 21 | 4.20 | 195 | 0 | 0 | 5 | 266 | 113 | 132 | 29 | 89 | 10 | 29 | 6 | 1,071 | 3 | 7.24 | 3.31 | 2.19 | 1.08 | 18.2 | 8.3 | 1.46 | .317 | 4.90 | 99 | 4.35 | 105 | 9.88 | -5 | |
| 25 | D. Matsuzaka | 236.2 | 44 | 13 | 16 | .448 | 43 | 5.48 | 200 | 0 | 0 | 0 | 227 | 144 | 151 | 28 | 117 | 12 | 1 | 1 | 1,046 | 7 | 7.61 | 4.45 | 1.71 | 1.06 | 19.1 | 11.2 | 1.45 | .289 | 5.74 | 127 | 4.55 | 112 | 8.63 | -12.7 | |