| NAME | SV | ERA | SEASON | TM | G | W | L | W% | GS | SO | CG | SHO | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Eckersley | 48 | 0.61 | 1990 |  OAK | 63 | 4 | 2 | .667 | 0 | 73 | 0 | 0 | 73.1 | 41 | 5 | 9 | 2 | 4 | 0 | 61 | 1 | 262 | 0 | 8.96 | 0.49 | 18.25 | 0.25 | 27.9 | 1.5 | 0.61 | .213 | 1.10 | 17 | 1.33 | 35 | 5.03 | 20.6 |
| 2 | | J. Papelbon | 35 | 0.92 | 2006 |  BOS | 59 | 4 | 2 | .667 | 0 | 75 | 0 | 0 | 68.1 | 40 | 7 | 8 | 3 | 13 | 1 | 49 | 2 | 257 | 2 | 9.88 | 1.71 | 5.77 | 0.40 | 29.2 | 5.1 | 0.78 | .224 | 1.05 | 20 | 2.13 | 48 | 5.27 | 17.7 |
| 3 | | F. Rodney | 48 | 0.60 | 2012 |  TBR | 76 | 2 | 2 | .500 | 0 | 76 | 0 | 0 | 74.2 | 43 | 5 | 9 | 2 | 15 | 3 | 65 | 1 | 282 | 4 | 9.16 | 1.81 | 5.07 | 0.24 | 27.0 | 5.3 | 0.78 | .220 | 1.08 | 16 | 2.12 | 52 | 5.18 | 16.2 |
| 4 | | Z. Britton | 47 | 0.54 | 2016 |  BAL | 69 | 2 | 1 | .667 | 0 | 74 | 0 | 0 | 67.0 | 38 | 4 | 7 | 1 | 18 | 0 | 63 | 3 | 254 | 10 | 9.94 | 2.42 | 4.11 | 0.13 | 29.1 | 7.1 | 0.84 | .230 | 0.94 | 13 | 1.93 | 44 | 5.10 | 17.7 |
| 5 |  | B. Treinen | 38 | 0.78 | 2018 | OAK | 68 | 9 | 2 | .818 | 0 | 100 | 0 | 0 | 80.1 | 46 | 7 | 12 | 2 | 21 | 1 | 58 | 3 | 315 | 6 | 11.20 | 2.35 | 4.76 | 0.22 | 31.7 | 6.7 | 0.83 | .230 | 1.34 | 19 | 1.81 | 44 | 5.15 | 21 |
| 6 |  | E. Clase | 47 | 0.61 | 2024 |  CLE | 74 | 4 | 2 | .667 | 0 | 66 | 0 | 0 | 74.1 | 39 | 5 | 10 | 2 | 10 | 2 | 66 | 1 | 270 | 2 | 7.99 | 1.21 | 6.60 | 0.24 | 24.4 | 3.7 | 0.66 | .195 | 1.21 | 15 | 2.22 | 55 | 4.72 | 15.2 |
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