The Chicago Cubs have the highest run differential by a team this season, with a differential of 107 runs.

Interpreted as:

team most run diff this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	107	2025	73	.616	45	28	2,528	390	643	133	15	99	382	255	18	579	90	15	2,830	1,103	247	6	23	9	32	.254	.324	.436	.761
2	Yankees	98	2025	72	.583	42	30	2,441	370	618	126	11	109	356	286	31	636	54	18	2,786	1,093	246	3	25	20	48	.253	.336	.448	.784
3	Tigers	84	2025	74	.635	47	27	2,505	358	631	117	14	89	344	237	30	647	27	6	2,794	1,043	220	4	18	7	42	.252	.322	.416	.738
4	Mets	79	2025	73	.616	45	28	2,438	332	602	120	13	93	323	270	48	565	59	10	2,783	1,027	226	3	24	14	64	.247	.331	.421	.752
5	Dodgers	76	2025	74	.608	45	29	2,534	413	672	125	12	115	397	279	26	605	44	12	2,870	1,166	252	3	28	17	56	.265	.341	.460	.801
6	Rays	64	2025	73	.548	40	33	2,447	333	612	116	4	77	316	225	24	615	97	22	2,722	967	197	6	20	3	48	.250	.317	.395	.712
7	Astros	47	2025	73	.575	42	31	2,433	306	621	108	7	75	292	210	33	557	43	16	2,705	968	190	9	20	6	62	.255	.320	.398	.718
8	Giants	44	2025	73	.562	41	32	2,404	311	561	110	12	70	296	262	26	619	42	15	2,727	905	192	13	22	6	46	.233	.313	.376	.689
9	Reds	42	2025	73	.521	38	35	2,454	341	606	122	7	82	328	259	23	638	61	22	2,760	988	211	6	18	7	44	.247	.322	.403	.725
10	Phillies	31	2025	73	.589	43	30	2,485	342	638	114	11	78	326	255	28	569	63	14	2,791	1,008	203	7	16	9	44	.257	.331	.406	.736
11	Cardinals	28	2025	73	.521	38	35	2,483	340	637	127	4	68	322	233	39	567	40	13	2,784	976	199	9	20	10	55	.257	.328	.393	.721
12	Rangers	22	2025	73	.493	36	37	2,388	266	544	98	6	76	257	201	27	593	62	17	2,638	882	180	3	19	6	36	.228	.293	.369	.662
13	Padres	20	2025	72	.542	39	33	2,400	304	596	106	10	62	280	229	19	512	55	14	2,688	908	178	17	23	8	48	.248	.316	.378	.694
14	Brewers	19	2025	74	.527	39	35	2,454	319	581	102	8	66	295	251	31	613	90	22	2,770	897	176	16	18	8	36	.237	.313	.366	.679
15	Red Sox	18	2025	76	.513	39	37	2,621	358	651	141	11	92	343	260	36	704	63	15	2,938	1,090	244	6	15	15	42	.248	.323	.416	.739
16	Braves	13	2025	71	.451	32	39	2,409	295	590	97	6	76	284	243	22	609	37	12	2,697	927	179	7	16	8	47	.245	.318	.385	.703
17	Twins	6	2025	72	.500	36	36	2,422	300	585	113	8	76	288	209	45	602	36	14	2,692	942	197	1	15	4	48	.242	.312	.389	.701
18	Mariners	2	2025	73	.507	37	36	2,484	317	600	98	4	91	306	265	37	649	75	20	2,812	979	193	11	15	7	43	.242	.322	.394	.716
19	Diamondbacks	-6	2025	72	.500	36	36	2,435	365	615	130	15	102	357	265	33	559	54	16	2,771	1,081	247	12	26	9	49	.253	.331	.444	.775
20	Blue Jays	-11	2025	72	.542	39	33	2,428	307	617	124	3	73	295	231	26	494	38	11	2,724	966	200	16	23	12	54	.254	.323	.398	.721
21	Royals	-23	2025	73	.479	35	38	2,455	243	612	118	14	49	239	170	24	503	57	24	2,688	905	181	16	23	10	37	.249	.302	.369	.670
22	Guardians	-25	2025	71	.507	36	35	2,310	273	534	97	7	73	258	222	27	576	56	16	2,593	864	177	9	25	10	46	.231	.303	.374	.677
23	Angels	-57	2025	72	.486	35	37	2,395	297	540	96	8	100	286	180	34	702	34	13	2,633	952	204	7	17	9	42	.225	.287	.397	.685
24	Pirates	-58	2025	74	.392	29	45	2,434	235	546	91	13	50	225	244	28	638	68	22	2,726	813	154	6	14	10	66	.224	.301	.334	.635
25	Nationals	-69	2025	73	.411	30	43	2,422	305	580	120	10	70	289	207	37	547	61	24	2,691	930	200	10	15	3	48	.239	.307	.384	.691