The Brooklyn Dodgers had the highest run differential by a team in 1941, with a differential of 219 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	219	1941	157	.649	100	54	5,485	800	1,494	286	69	101	747	600	27	535	36		6,218	2,221	456	106	103	.272	.347	.405	.752
2	Yankees	199	1941	156	.656	101	53	5,444	830	1,464	243	60	151	774	616	28	564	51	33	6,137	2,280	454	49	102	.269	.346	.419	.765
3	Cardinals	145	1941	155	.634	97	56	5,457	734	1,482	254	56	70	664	541	28	543	47		6,152	2,058	380	126	102	.272	.340	.377	.717
4	Red Sox	115	1941	155	.545	84	70	5,359	865	1,517	304	55	124	806	685	20	566	67	51	6,179	2,303	483	115	127	.283	.366	.430	.796
5	Reds	52	1941	154	.571	88	66	5,218	616	1,288	213	33	64	567	474	22	429	68		5,817	1,759	310	103	122	.247	.312	.337	.649
6	Pirates	47	1941	156	.526	81	73	5,297	690	1,417	233	65	56	634	545	15	516	59		5,952	1,948	354	95	119	.268	.338	.368	.705
7	Indians	9	1941	155	.487	75	79	5,283	677	1,350	249	84	103	618	511	18	603	63	47	5,913	2,076	436	101	94	.256	.323	.393	.716
8	Cubs	-4	1941	155	.455	70	84	5,230	666	1,323	239	25	99	610	559	14	668	39		5,901	1,909	363	98	100	.253	.327	.365	.692
9	White Sox	-11	1941	156	.500	77	77	5,404	638	1,376	245	47	47	567	509	24	476	91	53	6,011	1,856	339	74	129	.255	.322	.343	.665
10	Giants	-42	1941	156	.484	74	79	5,395	667	1,401	248	35	95	625	504	23	518	36		6,018	2,004	378	96	116	.260	.326	.371	.697
11	Tigers	-57	1941	155	.487	75	79	5,370	686	1,412	247	55	81	637	602	23	583	43	28	6,077	2,012	383	82	118	.263	.340	.375	.714
12	Browns	-58	1941	157	.455	70	84	5,408	765	1,440	281	58	91	729	775	13	552	50	39	6,285	2,110	430	89	118	.266	.360	.390	.750
13	Senators	-70	1941	156	.455	70	84	5,521	728	1,502	257	80	52	671	470	14	488	79	36	6,067	2,075	389	62	115	.272	.331	.376	.707
14	Athletics	-127	1941	154	.416	64	90	5,336	713	1,431	240	69	85	659	573	8	588	27	36	5,993	2,064	394	76	139	.268	.340	.387	.727
15	Braves	-128	1941	156	.403	62	92	5,414	592	1,357	231	38	48	552	471	13	604	61		5,968	1,808	317	70	120	.251	.312	.334	.646
16	Phillies	-292	1941	155	.279	43	111	5,233	501	1,277	188	38	64	467	451	22	595	65		5,796	1,733	290	90	142	.244	.307	.331	.638