The Cleveland Indians had the highest run differential by a team in 1948, with a differential of 273 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Indians	273	1948	156	.626	97	58	5,446	840	1,534	242	54	155	801	646	24	575	54	44	6,201	2,349	451	85	132	.282	.360	.431	.792
2	Yankees	224	1948	154	.610	94	60	5,324	857	1,480	251	75	139	806	623	23	478	24	24	6,048	2,298	465	78	136	.278	.356	.432	.788
3	Red Sox	187	1948	155	.619	96	59	5,363	907	1,471	277	40	121	854	821	32	549	38	17	6,282	2,191	438	66	144	.274	.374	.409	.782
4	Braves	157	1948	154	.595	91	62	5,297	739	1,458	272	49	95	695	667	17	537	43		6,121	2,113	416	140	113	.275	.358	.399	.757
5	Cardinals	96	1948	155	.552	85	69	5,302	742	1,396	238	58	105	680	590	22	523	24		5,990	2,065	401	76	125	.263	.340	.389	.729
6	Giants	80	1948	155	.506	78	76	5,277	780	1,352	210	49	164	733	597	19	643	51		5,958	2,152	423	65	113	.256	.334	.408	.742
7	Dodgers	77	1948	155	.545	84	70	5,328	744	1,393	256	54	91	671	604	18	685	114		6,050	2,030	401	100	100	.261	.339	.381	.720
8	Pirates	5	1948	156	.539	83	71	5,286	706	1,388	191	54	108	650	580	21	578	68		5,943	2,011	353	56	100	.263	.338	.380	.718
9	Athletics	-6	1948	154	.545	84	70	5,181	729	1,345	231	47	68	684	725	22	523	40	32	6,048	1,874	346	120	137	.260	.353	.362	.715
10	Tigers	-25	1948	154	.506	78	76	5,235	700	1,396	219	58	78	661	671	27	504	22	32	6,063	1,965	355	130	134	.267	.353	.375	.728
11	Cubs	-104	1948	155	.416	64	90	5,352	597	1,402	225	44	87	564	444	29	574	39		5,895	1,976	356	70	104	.262	.322	.369	.691
12	Phillies	-136	1948	155	.429	66	88	5,287	591	1,367	227	39	91	548	437	21	596	68		5,826	1,945	357	81	99	.259	.318	.368	.686
13	Reds	-162	1948	153	.418	64	89	5,127	588	1,266	221	37	104	548	477	16	582	42		5,699	1,873	362	79	120	.247	.313	.365	.678
14	Browns	-178	1948	155	.386	59	94	5,303	671	1,438	251	62	63	625	578	19	571	63	44	6,013	2,002	376	113	131	.271	.345	.378	.722
15	Senators	-217	1948	154	.366	56	97	5,111	578	1,245	203	75	31	537	569	20	570	76	48	5,784	1,691	309	84	124	.244	.322	.331	.653
16	White Sox	-256	1948	154	.336	51	101	5,192	558	1,303	172	39	55	532	594	12	528	46	47	5,871	1,718	266	73	119	.251	.329	.331	.660