The Brooklyn Dodgers had the highest run differential by a team in 1951, with a differential of 183 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	183	1951	158	.618	97	60	5,492	855	1,511	249	37	184	794	603	44	649	89	70	6,214	2,386	470	75	147	.275	.352	.434	.786
2	Yankees	177	1951	154	.636	98	56	5,194	798	1,395	208	48	140	741	602	37	545	78	39	5,924	2,119	396	91	138	.269	.349	.408	.757
3	Giants	140	1951	157	.624	98	59	5,360	781	1,396	201	53	179	734	671	40	624	55	34	6,153	2,240	433	82	116	.260	.347	.418	.765
4	Indians	102	1951	155	.604	93	61	5,250	696	1,346	208	35	140	658	605	27	632	52	35	5,945	2,044	383	63	125	.256	.336	.389	.726
5	Red Sox	79	1951	154	.565	87	67	5,378	804	1,428	233	32	127	757	756	18	594	20	21	6,211	2,106	392	59	169	.266	.358	.392	.750
6	White Sox	70	1951	155	.526	81	73	5,378	714	1,453	229	64	86	668	594	51	525	99	70	6,126	2,068	379	103	121	.270	.348	.385	.733
7	Braves	61	1951	155	.494	76	78	5,293	723	1,385	234	37	130	683	565	31	617	80	34	5,968	2,083	401	79	139	.262	.336	.394	.730
8	Cardinals	12	1951	155	.526	81	73	5,317	683	1,404	230	57	95	629	569	31	492	30	30	6,003	2,033	382	86	134	.264	.339	.382	.721
9	Phillies	4	1951	154	.474	73	81	5,332	648	1,384	199	47	108	609	505	21	525	63	28	5,961	2,001	354	103	111	.260	.326	.375	.701
10	Athletics	-9	1951	154	.455	70	84	5,277	736	1,381	262	43	102	685	677	34	564	47	36	6,049	2,035	407	61	118	.262	.349	.386	.735
11	Tigers	-56	1951	154	.474	73	81	5,336	685	1,413	231	35	104	636	567	18	523	37	34	6,007	2,026	370	86	138	.265	.337	.380	.717
12	Senators	-92	1951	154	.403	62	92	5,329	672	1,399	242	45	54	627	560	26	514	45	38	5,979	1,893	341	64	145	.263	.336	.355	.691
13	Reds	-108	1951	155	.442	68	86	5,285	559	1,309	215	33	88	528	415	11	577	44	40	5,775	1,854	336	64	125	.248	.304	.351	.655
14	Cubs	-136	1951	155	.403	62	92	5,307	614	1,327	200	47	103	572	477	22	647	63	30	5,862	1,930	350	56	139	.250	.315	.364	.678
15	Pirates	-156	1951	155	.416	64	90	5,318	689	1,372	218	56	137	648	557	22	615	29	27	5,973	2,113	411	76	130	.258	.331	.397	.728
16	Browns	-271	1951	154	.338	52	102	5,219	611	1,288	223	47	86	555	521	16	692	35	38	5,848	1,863	356	92	151	.247	.317	.357	.674