The Brooklyn Dodgers had the highest run differential by a team in 1953, with a differential of 266 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	266	1953	155	.682	105	49	5,373	955	1,529	274	59	208	887	655	35	686	90	47	6,138	2,545	541	75	115	.285	.366	.474	.840
2	Yankees	254	1953	151	.656	99	52	5,194	801	1,420	226	52	139	762	655	34	643	34	44	5,960	2,167	417	77	105	.273	.358	.417	.776
3	Braves	149	1953	157	.597	92	62	5,349	738	1,422	227	52	156	691	439	27	637	46	27	5,895	2,221	435	80	122	.266	.325	.415	.740
4	Indians	143	1953	155	.597	92	62	5,285	770	1,426	201	29	160	730	608	35	682	33	29	6,018	2,165	390	90	125	.270	.349	.410	.759
5	White Sox	124	1953	156	.578	89	65	5,212	716	1,345	226	53	74	669	600	54	529	73	55	5,986	1,899	353	120	146	.258	.341	.364	.705
6	Senators	73	1953	152	.500	76	76	5,149	687	1,354	230	53	69	644	595	31	604	65	36	5,857	1,897	352	82	134	.263	.343	.368	.711
7	Cardinals	55	1953	157	.539	83	71	5,397	768	1,474	281	56	140	722	574	39	617	18	22	6,065	2,287	477	55	141	.273	.347	.424	.771
8	Phillies	50	1953	156	.539	83	71	5,290	716	1,400	228	62	115	657	530	29	597	42	21	5,916	2,097	405	67	109	.265	.335	.396	.731
9	Red Sox	24	1953	153	.549	84	69	5,246	656	1,385	255	37	101	614	495	38	600	33	45	5,878	2,017	393	99	109	.264	.332	.384	.716
10	Giants	21	1953	155	.455	70	84	5,362	768	1,452	195	45	176	739	499	28	608	31	21	5,956	2,265	416	67	129	.271	.336	.422	.758
11	Reds	-74	1953	155	.442	68	86	5,343	714	1,396	190	34	166	669	485	16	701	25	20	5,912	2,152	390	68	113	.261	.325	.403	.727
12	Athletics	-167	1953	157	.383	59	95	5,455	632	1,398	205	38	116	588	498	24	602	41	24	6,028	2,027	359	51	141	.256	.321	.372	.693
13	Cubs	-202	1953	155	.422	65	89	5,272	633	1,372	204	57	137	588	514	14	746	49	21	5,873	2,101	398	73	140	.260	.328	.399	.726
14	Browns	-223	1953	154	.351	54	100	5,264	555	1,310	214	25	112	522	506	17	644	17	34	5,876	1,910	351	89	144	.249	.317	.363	.680
15	Tigers	-228	1953	158	.390	60	94	5,553	695	1,479	259	44	108	660	505	30	602	30	35	6,151	2,150	411	63	139	.266	.331	.387	.718
16	Pirates	-265	1953	154	.325	50	104	5,253	622	1,297	178	49	99	571	524	36	715	41	39	5,902	1,870	326	89	117	.247	.319	.356	.675