The Milwaukee Braves had the highest run differential by a team in 1959, with a differential of 101 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Braves	101	1959	157	.551	86	70	5,388	724	1,426	216	36	177	683	488	27	765	41	14	6,010	2,245	429	64	43	64	130	.265	.326	.417	.743
2	Indians	99	1959	154	.578	89	65	5,288	745	1,390	216	25	167	682	433	39	721	33	36	5,860	2,157	408	60	40	25	119	.263	.321	.408	.729
3	Giants	92	1959	154	.539	83	71	5,281	705	1,377	239	35	167	660	473	25	875	81	34	5,890	2,187	441	73	38	57	96	.261	.322	.414	.736
4	White Sox	81	1959	156	.610	94	60	5,297	669	1,325	220	46	97	620	580	49	634	113	53	6,054	1,928	363	84	44	45	107	.250	.327	.364	.691
5	Yankees	40	1959	155	.513	79	75	5,379	687	1,397	224	40	153	651	457	30	828	45	22	5,980	2,160	417	76	38	37	101	.260	.319	.402	.721
6	Dodgers	35	1959	156	.564	88	68	5,282	705	1,360	196	46	148	667	591	28	891	84	51	6,033	2,092	390	100	32	61	115	.257	.334	.396	.730
7	Red Sox	30	1959	154	.487	75	79	5,225	726	1,335	248	28	125	678	626	23	810	68	25	5,985	2,014	401	65	46	31	120	.256	.335	.385	.721
8	Redlegs	26	1959	154	.481	74	80	5,288	764	1,448	258	34	161	721	499	32	763	65	28	5,922	2,257	453	53	50	43	121	.274	.337	.427	.764
9	Cubs	-15	1959	155	.481	74	80	5,296	673	1,321	209	44	163	635	498	43	911	32	19	5,939	2,107	416	62	40	63	106	.249	.317	.398	.715
10	Tigers	-19	1959	154	.494	76	78	5,211	713	1,346	196	30	160	665	580	44	735	34	17	5,948	2,082	386	73	40	31	101	.258	.335	.400	.735
11	Pirates	-29	1959	155	.506	78	76	5,369	651	1,414	230	42	112	617	442	24	715	32	26	5,952	2,064	384	77	40	59	125	.263	.320	.384	.704
12	Orioles	-70	1959	155	.481	74	80	5,208	551	1,240	182	23	109	514	536	20	690	36	24	5,883	1,795	314	88	31	36	126	.238	.310	.345	.655
13	Athletics	-79	1959	154	.429	66	88	5,264	681	1,383	231	43	117	637	481	33	780	34	24	5,885	2,051	391	69	38	32	124	.263	.326	.390	.716
14	Senators	-82	1959	154	.409	63	91	5,092	619	1,205	173	32	163	580	517	26	881	51	34	5,734	1,931	368	64	35	20	127	.237	.308	.379	.688
15	Cardinals	-84	1959	154	.461	71	83	5,317	641	1,432	244	49	118	605	485	19	747	65	53	5,907	2,128	411	60	26	49	108	.269	.331	.400	.731
16	Phillies	-126	1959	155	.416	64	90	5,109	599	1,237	196	38	113	560	498	34	858	39	46	5,735	1,848	347	59	35	54	111	.242	.312	.362	.673