The St. Louis Cardinals had the highest run differential by a team in 1967, with a differential of 138 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	138	1967	161	.627	101	60	5,566	695	1,462	225	40	115	656	443	45	919	102	54	6,152	2,112	380	54	44	77	105	.263	.320	.379	.699
2	Red Sox	108	1967	162	.568	92	70	5,471	722	1,394	216	39	158	666	522	31	1,020	68	59	6,149	2,162	413	85	40	65	103	.255	.321	.395	.716
3	Giants	101	1967	162	.562	91	71	5,524	652	1,354	201	39	140	604	520	42	978	22	30	6,205	2,053	380	92	27	75	121	.245	.313	.372	.685
4	Tigers	96	1967	163	.562	91	71	5,410	683	1,315	192	36	152	618	626	51	994	37	21	6,200	2,035	380	78	35	54	114	.243	.325	.376	.702
5	Twins	81	1967	164	.562	91	71	5,458	671	1,309	216	48	131	619	512	46	976	55	37	6,116	2,014	395	66	34	52	114	.240	.309	.369	.678
6	Cubs	78	1967	162	.540	87	74	5,463	702	1,373	211	49	128	642	509	34	912	63	50	6,148	2,066	388	93	49	84	112	.251	.316	.378	.695
7	Orioles	62	1967	161	.472	76	85	5,456	654	1,312	215	44	138	624	531	41	1,002	54	37	6,164	2,029	397	82	54	67	103	.240	.310	.372	.682
8	Reds	41	1967	162	.537	87	75	5,519	604	1,366	251	54	109	560	372	31	969	92	63	6,012	2,052	414	56	34	74	111	.248	.297	.372	.669
9	White Sox	40	1967	162	.549	89	73	5,383	531	1,209	181	34	89	491	480	38	849	124	82	6,000	1,725	304	67	32	56	102	.225	.291	.320	.612
10	Phillies	31	1967	162	.506	82	80	5,401	612	1,306	221	47	103	553	545	27	1,033	79	62	6,096	1,930	371	90	33	101	108	.242	.313	.357	.670
11	Braves	-9	1967	162	.475	77	85	5,450	631	1,307	191	29	158	596	512	33	947	55	45	6,088	2,030	378	57	36	73	128	.240	.307	.372	.680
12	Pirates	-14	1967	163	.500	81	81	5,724	679	1,585	193	62	91	615	387	36	914	79	37	6,255	2,175	346	63	45	97	131	.277	.324	.380	.704
13	Angels	-20	1967	161	.522	84	77	5,307	567	1,265	170	37	114	524	453	31	1,021	40	36	5,902	1,851	321	88	23	49	114	.238	.301	.349	.650
14	Indians	-54	1967	162	.463	75	87	5,461	559	1,282	213	35	131	514	413	50	984	53	65	6,037	1,958	379	85	28	38	102	.235	.293	.359	.652
15	Dodgers	-76	1967	162	.451	73	89	5,456	519	1,285	203	38	82	465	485	43	881	56	47	6,110	1,810	323	91	35	75	133	.236	.301	.332	.633
16	Senators	-87	1967	161	.472	76	85	5,441	550	1,211	168	25	115	521	472	37	1,037	53	37	6,044	1,774	308	63	31	34	114	.223	.288	.326	.614
17	Yankees	-99	1967	163	.444	72	90	5,443	522	1,225	166	17	100	473	532	30	1,043	63	37	6,118	1,725	283	78	35	37	115	.225	.296	.317	.613
18	Astros	-116	1967	162	.426	69	93	5,506	626	1,372	259	46	93	581	537	26	934	88	38	6,177	2,002	398	65	43	88	123	.249	.317	.364	.680
19	Athletics	-127	1967	161	.385	62	99	5,349	533	1,244	212	50	69	481	452	42	1,019	132	59	5,938	1,763	331	59	36	39	79	.233	.296	.330	.625
20	Mets	-174	1967	162	.377	61	101	5,417	498	1,288	178	23	83	461	362	37	981	58	44	5,928	1,761	284	68	44	60	113	.238	.288	.325	.613