The Los Angeles Dodgers had the highest run differential by a team in 1981, with a differential of 94 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	94	1981	110	.573	63	47	3,751	450	984	133	20	82	427	331	17	550	73	46	4,188	1,403	235	62	27	38	83	.262	.323	.374	.697
2	Yankees	78	1981	107	.551	59	48	3,529	421	889	148	22	100	403	391	7	434	47	30	3,994	1,381	270	40	27	30	99	.252	.325	.391	.717
3	Rangers	63	1981	105	.543	57	48	3,581	452	968	178	15	49	418	295	21	396	46	41	3,972	1,323	242	36	39	40	84	.270	.326	.369	.696
4	Astros	63	1981	110	.555	61	49	3,693	394	948	160	35	45	369	340	8	488	81	43	4,155	1,313	240	79	35	49	69	.257	.318	.356	.673
5	Athletics	55	1981	109	.587	64	45	3,677	458	910	119	26	104	430	342	16	647	98	47	4,113	1,393	249	46	32	26	75	.247	.312	.379	.691
6	White Sox	53	1981	106	.509	54	52	3,615	476	982	135	27	76	438	322	43	518	86	44	4,064	1,399	238	48	36	16	90	.272	.335	.387	.722
7	Expos	49	1981	108	.556	60	48	3,591	443	883	146	28	81	407	368	16	498	138	40	4,068	1,328	255	63	30	55	74	.246	.316	.370	.686
8	Cardinals	47	1981	103	.578	59	43	3,537	464	936	158	45	50	431	379	16	495	88	45	4,013	1,334	253	46	35	41	82	.265	.336	.377	.713
9	Red Sox	38	1981	108	.546	59	49	3,820	519	1,052	168	17	90	492	378	13	520	32	31	4,281	1,524	275	37	33	18	98	.275	.340	.399	.739
10	Brewers	34	1981	109	.569	62	47	3,743	493	961	173	20	96	475	300	29	461	39	36	4,152	1,462	289	35	45	35	83	.257	.313	.391	.704
11	Reds	24	1981	108	.611	66	42	3,637	464	972	190	24	64	429	375	18	553	58	37	4,123	1,402	278	53	40	38	98	.267	.335	.385	.721
12	Tigers	23	1981	109	.550	60	49	3,600	427	922	148	29	65	403	404	18	500	61	37	4,109	1,323	242	50	37	33	98	.256	.331	.368	.699
13	Angels	23	1981	110	.464	51	59	3,688	476	944	134	16	97	439	393	29	571	44	33	4,191	1,401	247	51	30	23	97	.256	.330	.380	.710
14	Phillies	19	1981	107	.551	59	48	3,665	491	1,002	165	25	69	453	372	23	432	103	46	4,141	1,424	259	44	37	42	79	.273	.341	.389	.730
15	Giants	13	1981	111	.505	56	55	3,766	427	941	161	26	63	399	386	14	543	89	50	4,258	1,343	250	65	27	49	91	.250	.320	.357	.676
16	Orioles	-8	1981	105	.562	59	46	3,516	429	883	165	11	88	408	404	15	454	41	34	3,985	1,334	264	26	24	29	110	.251	.329	.379	.708
17	Royals	-8	1981	103	.485	50	53	3,560	397	952	169	29	61	381	301	17	419	100	53	3,941	1,362	259	28	35	34	84	.267	.325	.383	.707
18	Indians	-11	1981	103	.505	52	51	3,507	431	922	150	21	39	397	343	13	379	119	37	3,952	1,231	210	46	43	31	91	.263	.327	.351	.678
19	Pirates	-18	1981	103	.451	46	56	3,576	407	920	176	30	55	384	278	15	494	122	52	3,959	1,321	261	54	36	37	60	.257	.311	.369	.680
20	Braves	-21	1981	107	.472	50	56	3,642	395	886	148	22	64	366	321	18	540	98	39	4,055	1,270	234	56	18	38	83	.243	.306	.349	.655
21	Padres	-73	1981	110	.373	41	69	3,757	382	963	170	35	32	350	311	14	525	83	62	4,184	1,299	237	72	30	39	87	.256	.313	.346	.659
22	Mets	-84	1981	105	.398	41	62	3,493	348	868	136	35	57	325	304	13	603	103	42	3,885	1,245	228	41	34	35	78	.248	.308	.356	.665
23	Mariners	-95	1981	110	.404	44	65	3,780	426	950	148	13	89	406	329	27	553	100	50	4,201	1,391	250	41	24	24	70	.251	.314	.368	.682
24	Twins	-108	1981	110	.376	41	68	3,676	378	884	147	36	47	359	275	11	497	34	27	4,025	1,244	230	36	27	28	95	.240	.293	.338	.632
25	Cubs	-113	1981	106	.369	38	65	3,546	370	838	138	29	57	348	342	13	611	72	41	3,984	1,205	224	53	30	44	78	.236	.303	.340	.643