The Los Angeles Dodgers had the highest run differential by a team in 2022, with a differential of 334 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	334	2022	162	.685	111	51	5,526	847	1,418	325	31	212	812	607	56	1,374	98	18	6,245	2,441	568	3	53	22	85	.257	.333	.442	.775
2	Yankees	240	2022	162	.611	99	63	5,422	807	1,308	225	8	254	764	620	70	1,391	102	33	6,167	2,311	487	14	41	36	121	.241	.325	.426	.751
3	Astros	219	2022	162	.654	106	56	5,409	737	1,341	284	13	214	715	528	60	1,179	83	22	6,048	2,293	511	9	42	18	118	.248	.319	.424	.743
4	Braves	180	2022	162	.623	101	61	5,509	789	1,394	298	11	243	753	470	66	1,498	87	31	6,082	2,443	552	1	36	13	103	.253	.317	.443	.761
5	Mets	166	2022	162	.623	101	61	5,489	772	1,422	272	27	171	735	510	112	1,217	62	22	6,175	2,261	470	20	44	25	122	.259	.332	.412	.744
6	Cardinals	135	2022	162	.574	93	69	5,496	772	1,386	290	21	197	739	537	80	1,226	95	25	6,163	2,309	508	5	45	11	112	.252	.325	.420	.745
7	Blue Jays	96	2022	162	.568	92	70	5,555	775	1,464	307	12	200	756	500	55	1,242	67	35	6,151	2,395	519	8	33	13	136	.264	.329	.431	.760
8	Mariners	67	2022	162	.556	90	72	5,375	690	1,236	229	19	197	663	596	89	1,397	83	27	6,114	2,094	445	9	45	17	120	.230	.315	.390	.704
9	Guardians	64	2022	162	.568	92	70	5,558	698	1,410	273	31	127	662	450	81	1,122	119	27	6,163	2,126	431	22	52	36	115	.254	.316	.383	.699
10	Phillies	62	2022	162	.537	87	75	5,496	747	1,392	255	29	205	719	478	52	1,363	105	28	6,076	2,320	489	6	44	15	116	.253	.317	.422	.739
11	Rays	52	2022	162	.531	86	76	5,412	666	1,294	296	17	139	634	500	57	1,395	95	37	6,007	2,041	452	7	31	13	93	.239	.309	.377	.686
12	Padres	45	2022	162	.549	89	73	5,468	705	1,317	275	18	153	682	574	65	1,327	49	22	6,170	2,087	446	17	46	24	95	.241	.318	.382	.700
13	Brewers	37	2022	162	.531	86	76	5,417	725	1,271	251	17	219	703	577	80	1,464	96	30	6,122	2,213	487	11	37	25	117	.235	.315	.409	.724
14	Giants	19	2022	162	.500	81	81	5,392	716	1,261	255	18	183	683	571	95	1,462	64	16	6,117	2,101	456	6	53	14	109	.234	.315	.390	.705
15	Twins	12	2022	162	.481	78	84	5,476	696	1,356	269	18	178	668	518	62	1,353	38	17	6,112	2,195	465	10	46	11	133	.248	.317	.401	.718
16	Orioles	-14	2022	162	.512	83	79	5,429	674	1,281	275	25	171	639	476	83	1,390	95	31	6,043	2,119	471	12	43	10	95	.236	.305	.390	.695
17	White Sox	-31	2022	162	.500	81	81	5,611	686	1,435	272	9	149	654	388	73	1,269	58	10	6,123	2,172	430	16	35	9	127	.256	.310	.387	.698
18	Rangers	-36	2022	162	.420	68	94	5,478	707	1,308	224	20	198	670	456	47	1,446	128	41	6,029	2,166	442	10	38	12	82	.239	.301	.395	.696
19	Diamondbacks	-38	2022	162	.457	74	88	5,351	702	1,232	262	24	173	658	531	60	1,341	104	29	6,023	2,061	459	31	50	14	97	.230	.304	.385	.689
20	Angels	-45	2022	162	.451	73	89	5,423	623	1,265	219	31	190	600	449	54	1,539	77	27	5,976	2,116	440	25	25	28	95	.233	.297	.390	.687
21	Red Sox	-52	2022	162	.481	78	84	5,539	735	1,427	352	12	155	704	478	63	1,373	52	20	6,142	2,268	519	12	50	23	131	.258	.321	.409	.731
22	Cubs	-74	2022	162	.457	74	88	5,425	657	1,293	265	31	159	620	507	84	1,448	111	37	6,071	2,097	455	19	36	16	130	.238	.311	.387	.698
23	Marlins	-90	2022	162	.426	69	93	5,395	586	1,241	248	20	144	554	436	70	1,429	122	29	5,941	1,961	412	4	36	6	120	.230	.294	.363	.658
24	Tigers	-156	2022	162	.407	66	96	5,378	557	1,240	235	27	110	530	380	58	1,413	47	24	5,870	1,859	372	10	44	8	108	.231	.286	.346	.632
25	Reds	-167	2022	162	.383	62	100	5,380	648	1,264	235	18	156	618	452	92	1,430	58	33	5,969	2,003	409	12	33	6	127	.235	.304	.372	.676